autokoids advance pharmacology assignment

1. AUTOKOIDS
PROSTAGLANDIN’S

2. Prostaglandins
 Those agents/chemicals/local hormone which
are secreted from Prostate gland is called
prostaglandins.
 Also c/d Eicosanoids.
 Formed fromArachidonic acid.
 U.V.Euler got nobel prize for PG’s.

3. Membrane phospholipid
Arachidonic acid +2 O₂
[COX]
PGG₂
Cyclo [Peroxidase activity]
EndoPer PGH₂
OXIDASE
Isomerase Thromboxane Prostacyclin synthase
synthase
PGE₂ PGF₂α PGD₂ TXA₂ PGI₂
TxB₂ 6-keto PGF₁α

4.  Str. Of PG have –
.5 memb ring
.2 side chain
.A,B,C... Series-strl base
.subscripn1,2,3....-no. of double bond
.α- shows OH- grp orientation

5. COX
Cox-1 Cox-2 Cox-3
.GIT HEART- .Pain . C.C.of Brain
.Cnstitutive .Inflamn . Cox-3 is vari
.Basal-.Acid Inducible by .CK ent of Cox-1.
.Mucus .GF .Causes-.Fever
.House keeping .Other stimuli .Pain
.Hoemostatis
.maintain Renal
function
‘’All PG’s are derivative of Prostanic Acid’’

6. PATHWAY-
COX PATHWAY LOX PATHWAY
PG’s Formation LT’s Formation
Cyclic Str. Open chain Str.

7. Action,pathophysiological roles of
PG’s -
*Blood vessel – .PGE₂ -Vasodilation
.PGI₂ - vasodilatn , hypotentn
.PGF₂α- contraction
*‘PAD{Patent Arteriosus Ductus} - During faetal life PGE₂
keep Arteriosus ductus Patent(open).
*At birth PGE2 synthesis inhibit, then Ductus close.
*If ductus not closed after birth then called ‘Foramen Ovale
Disease’
*DRUG - .Indomethacin
.Aspirin Given after delivery if ductus not close

8.  Blood platelets -
TXA2 PGI2
Produced by platelets Produced by Endothelium
Cause agregation of
platelets
Do not agregate platelets
(potent inhibitor of platelet
agregation)

9.  Uterus- .PGF2α
.PGE2 Contraction
Pragnant & nonprgnt
 PGF2α is potent PG for abortion
these are used for terminate Pragnancy
*At term– PGF2α is found in maternal blood.
*Dismanhurrheia is due to PGE2.
.Aspirin- Prevention
.Methanemic acid -DOC
*PGF2α causes cervical ripening.

10.  GIT- .Longitudenal muscles_ E2
 F2α contrctn
 Circular ms. _E2 Relaxation
 F2α contraction
 PGE2- .Diarrhea
.watery fluid
. Acid secretion
. Antiulcergenic
 Specific drug-Mesoprostol
 DOC – PPI’s { Lansoprazole }

11. Classification of PG’s
Natural Analogue
Alprostadil Gemiprost
Dinoprostol Mesoprostol
Dinoprost Latanoprost
Prostacycline Carboprost
Travoprost
Bimatoprost

12. # F2 Analogue used in
Glaucoma treatment.
.Latanoprost
.Travoprost
.Bimatoprost
 Gemiprost , Carboprost
causes relaxation &
contraction . So used in
Abortion.
 Carboprost used in Post
Partam Haemorrhage.
 By- Drx Rishav Brijpuriya