ENZYME ALGINOGELS – HYDRATED ALGINATES WITH AN EMBEDDED ANTI-BACTERIAL ENZYME SYSTEM IN THE TREATMENT OF PEDIATRIC BURN PATIENT: OUR EXPERIENCE Giancarlo delli Santi1, Marco Palombo1, Agostino Bruno1, Carmela La Greca2, Paolo Palombo1 1Burn Centre and Plastic and Reconstructive Surgery Department, S. Eugenio Hospital (Roma, Italy); 2School of Plastic and Reconstructive Surgery ”A. Gemelli” Hospital -Catholic University S.C (Roma, Italy).

1. Enzyme alginogels – hydrated alginates with
an embedded anti-bacterial enzyme system
in the Treatment of Pediatric Burn Patient:
Our Experience
Palombo M, La Greca C, delli Santi G, Palombo P
Burn Center and Plastic Surgery Department- S. Eugenio Hospital - Rome
Chief: Prof. P. Palombo
cguricerca@gmail.com - +390651002200 Roma Burn Center

2. Introduction
The goal, in the treatment of deep second-degree
burn, is to achieve, in the shortest time, the
debridement of the wound to prepare the patients
for skin grafting, in the treatment of the superficial
second-degree burn, is to reach, avoiding infections
and preventing scarring, the restitutio ad integrum.
cguricerca@gmail.com - +390651002200 Roma Burn Center

3. Aim
This study evaluates the clinical efficacy of
enzyme alginogels – hydrated alginates with
an embedded anti-bacterial enzyme system
(Flaminal® Hydro and Forte) in the
second degree burns in pediatric population
cguricerca@gmail.com - +390651002200 Roma Burn Center

4. Methods
The products were used as wound dressing in
pediatric patients with second degree burns
between November 2012 and April 2013
Patients
39
Male Female
19 20
The dressing was applied and kept in situ
covered by paraffin gauze.
- Ease of application
- Pain
- Home management
- Times of healing
- Cosmetic results
cguricerca@gmail.com - +390651002200 Roma Burn Center
Age (range) Age (average)
45 days – 15 years 5 years
We evaluated*
*at each control on a scale from 1 to 10

5. Results
The medical treatment promoted a faster and
complete wound healing without major
complications
No one children had to stop treatment
In deep II burns the treatment is useful to debride
the wound, shortening surgical times
cguricerca@gmail.com - +390651002200 Roma Burn Center
Parameters Scale (average of score)
Ease of application 8.7
Pain* 3.1
Home management (difficulty) 2.2
Times of healing (rate) 8.9
Cosmetic results 9
*measured as duration of crying in infants and young children (20 minutes on average) and
reported as mild discomfort in older children (for 20 minutes on average)

6. Case n.1
Burn by firecracker
in child 4 y.o.
treated as outpatient
with Flaminal ® Forte
and Hydro
At the first access
At the first control
after six daysControls at 1 month (left photo)
and 3 months (right photo)
cguricerca@gmail.com - +390651002200 Roma Burn Center

7. Case n.2
cguricerca@gmail.com - +390651002200 Roma Burn Center
Scald of forearm
in child 2 y.o.
treated as outpatient
with Flaminal ®
Forte and Hydro
At first access
After six days
Outcome

8. Case n.3
cguricerca@gmail.com - +390651002200 Roma Burn Center
Scald of abdomen
in child 6 y.o.
treated as outpatient
with Flaminal ® Hydro
At first access
After four days

9. Others
cguricerca@gmail.com - +390651002200 Roma Burn Center
Pre Post

10. Conclusion
Short terms topical application of the enzyme
alginogels – hydrated alginates in pediatric
population with second degree burns promoted
faster and complete wound healing avoiding
infections thanks to its formulation.
In deep second degree burn allows the chemical
debridement is preparatory to of skin graft
cguricerca@gmail.com - +390651002200 Roma Burn Center
Thanks