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AJAY SAH
Disoders Of Growth
Short Stature
 It is defined as height below 3rd centile or more than
2S.D. below the median height for age & gender (<-
2S.D.)
 3% of children in any given population will be short
 <-3S.D. :- Pathological short stature
 In b/w -2 & -3 S.D. :- Physiological short stature
Etiology
Assesment in Growth Pattern
Accurate Height Measurement:
 Infantometer (For children below 2yrs)
 Stadiometer ( For children above 2yrs)
Assessment of height velocity:
 1st yr : 25cm/yr
 Pre-Pubertal : 4-6 cm/yr
 Puberty : 10-12 cm/yr
Growth Chart comparison with normal
Population.
Comparison with child own genetic
potential:
 Assessmentof Body Propotion : (US:LS ratio)
 1.7 at Birth
 1.3 at 3 yrs
 1.1 by 6 yrs
 1 by 10 yrs
 0.9 in Adults
 Increase US:LS ratio in Rickets, Achondroplasia & Untreated Congenital
Hypothyroidism
 Decrease in Spondyloepiphyseal dysplasia & Vertebral Anomalies
Bone Age Assessment
 Should be done in all children with short stature
 Conventionally from radiograph of left hand & wrist using Tanner
WhiteHouse Method or Greulich & Pyle (GP) Atlas
 Bone age is delayed compared to chronological age in almost all cases
of short stature Except:-
 Famlial short stature (Equals)
 Precocious Puberty (Exceeds)
 In case of GH defeciency & Hypothyroidism, Bone age may be lower
than height Age, if endocrine condition is diagnosed late.
Diagnosis
Investigation
Management
 The specific management depends on the underlying cause.
 Councelling of parents & dietary advice.
 Intake of balanced diet containing recommended amounts of macro &
micronutrients.
 For Physiological Causes: Reassurance & Annual monitoring of
height & weight is sufficient.
 Dietary Rehabilitation for Undernutrition.
 Hypothyroidism : Levothyroxine replacement
 GH deficiency : Daily S.C. injection of GH is recommended
 For Skeletal Dysplasia: Limb lenthening procedures
 For any form of therapy, Monitoring with regular & accurate recording
of height is mandatory for satisfactory outcome.
THANK YOU

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Disoders of growth

  • 2. Short Stature  It is defined as height below 3rd centile or more than 2S.D. below the median height for age & gender (<- 2S.D.)  3% of children in any given population will be short  <-3S.D. :- Pathological short stature  In b/w -2 & -3 S.D. :- Physiological short stature
  • 4.
  • 5. Assesment in Growth Pattern Accurate Height Measurement:  Infantometer (For children below 2yrs)  Stadiometer ( For children above 2yrs) Assessment of height velocity:  1st yr : 25cm/yr  Pre-Pubertal : 4-6 cm/yr  Puberty : 10-12 cm/yr Growth Chart comparison with normal Population.
  • 6. Comparison with child own genetic potential:
  • 7.  Assessmentof Body Propotion : (US:LS ratio)  1.7 at Birth  1.3 at 3 yrs  1.1 by 6 yrs  1 by 10 yrs  0.9 in Adults  Increase US:LS ratio in Rickets, Achondroplasia & Untreated Congenital Hypothyroidism  Decrease in Spondyloepiphyseal dysplasia & Vertebral Anomalies
  • 8. Bone Age Assessment  Should be done in all children with short stature  Conventionally from radiograph of left hand & wrist using Tanner WhiteHouse Method or Greulich & Pyle (GP) Atlas  Bone age is delayed compared to chronological age in almost all cases of short stature Except:-  Famlial short stature (Equals)  Precocious Puberty (Exceeds)  In case of GH defeciency & Hypothyroidism, Bone age may be lower than height Age, if endocrine condition is diagnosed late.
  • 9.
  • 10.
  • 13. Management  The specific management depends on the underlying cause.  Councelling of parents & dietary advice.  Intake of balanced diet containing recommended amounts of macro & micronutrients.  For Physiological Causes: Reassurance & Annual monitoring of height & weight is sufficient.  Dietary Rehabilitation for Undernutrition.  Hypothyroidism : Levothyroxine replacement  GH deficiency : Daily S.C. injection of GH is recommended  For Skeletal Dysplasia: Limb lenthening procedures  For any form of therapy, Monitoring with regular & accurate recording of height is mandatory for satisfactory outcome.