3. HYPERTENSIVE DISORDER IN PREGNANCY
Hypertension in pregnancy is defined as a SBP of ≥ 140 mmHg and/or DBP ≥ 90
mmHg.
An increase of 15 mmHg diastolic and 30 mmHg systolic BP levels above
baseline BP is no longer recognised as hypertension if absolute values are
below 140/90mmHg.
4. Gestational Hypertension
Hypertension alone, detected for the first time after
20th week. The definition is changed to “transient”
when pressure normalises postpartum.
Chronic Hypertension
Hypertension diagnosed prior to 20thweek; or the
presence of hypertension preconception, or de novo
hypertension in late gestation that fails to resolve
postpartum.
5. PRE-ECLAMPSIA - ECLAMPSIA
Clinically diagnosed in the presence of de novo hypertension after 20th week, and
1 or more of the following:
i. Significant proteinuria
ii. Renal insufficiency – serum creatinine ≥ 90 μmol/L or oliguria
iii. Liver disease – raised transaminases and/or severe right upper quadrant or
epigastric pain
iv. Neurological problems – convulsions (eclampsia); hyperrefexia with clonus or
severe headaches, persistent visual disturbances (scotoma)
v. Haematological disturbances – thrombocytopenia, coagulopathy, haemolysis
vi. Fetal growth restriction
This is followed by normalisation of the BP by 3 months postpartum.
6. SEVERE PRE ECLAMPSIA
Systolic BP (SBP) of ≥ 170 and/or diastolic BP (DBP) of ≥ 110 mmHg on two occasions
along with significant proteinuria of ≥ 1g/day or
DBP of ≥ 100 mmHg on 2 occasions with significant proteinuria (1+ on dipstick), with
two or more symptoms and signs of imminent eclampsia, which includes:
Severe headache
Visual disturbance
Epigastric pain and/or vomiting
Clonus
Papilloedema
Liver tenderness
Abnormal liver enzymes (raised ALT or AST)
Platelet count < 100,000/cm3
HELLP syndrome (haemolysis, elevated liver enzymes, low platelets)
Intrauterine growth restriction (IUGR)
Pulmonary oedema and/or congestive cardiac failure
7. ECLAMPSIA
Defined as tonic-clonic (grand mal) seizure occurring in association with
features of PE.
May occur antepartum (45%), intrapartum (18 – 19%) or postpartum (36%).
8. ECLAMPSIA
All cases of eclampsia should have the baby delivered immediately regardless
of gestation after BP is controlled.
Sign and symptoms of severe pre eclampsia and eclampsia
Severe frontal headache
Vomiting
Blurring of vision
Epigastric pain
Hyper- reflexia
Severe hypertension
9. Management
Initiate Red Alert System
Give IM MgSO4 5g each buttock or IV MgSO4 4g slow bolus
Continue the MgSO4 infusion at 1g / hr
Anti-hypertensive drugs
Manage patient in lateral position
Suck out secretions / saliva
Ix: Hb, platelet, coagulation profile, LFT, BUSE, serum creatinine, serum uric
acid, GXM
Refer out (district hospital)
10. MgSO4 Therapy
IM regime loading dose
MgSo4 im deep intra-muscular 5g in each buttock (total 10g).
IM regime maintenance dose
MgSo4 IM deep intra-muscular injection 2.5g in each buttock every 4 hours
IV regime loading dose
MgSO4 iv 4 gm (diluted to 20 ml with NS) slow intravenous over 10-15 minutes,
MgSO4 iv infusion 1g / hour.
IV regime maintenance dose
MgSO4 5 gm (10mls) in 40mls DS, infuse at 10ml/hour (infusion rate 1g / hour).
25 gm MgSO4 at 2ml/hour
11. ANTI-HYPERTENSIVES INTRAVENOUS /
INFUSION DOSAGE – DURING HYPERTENSIVE
CRISIS
Labetalol
BOLUS (acute hypertension)
Give 5 mg IV bolus (over 2 min). If 5 mg not effective then double the dose every
10 min. (10 mg, 20 mg, 40 mg). Maximum bolus dose is 40 mg.
BP measure immediately before, and 5 minutes and 10 minutes after initial
dose.
Maximum effect within 5 minutes of each injection.
MAXIMUM TOTAL CUMULATIVE DOSE OF 300MG
12. LABETALOL
INFUSION
Drop-mat Infusion pump.
Labetalol hydrochloride 200 mg + 160 mL DS / NS / D5% (resultant 200 mL)
Infusion rate is 0.5mg/min (30mls/hr) to 2 mg/min (120mls/hr).
Adjusted by 0.5 mg/min every 15 minutes according to BP response.
Maximum infusion dose at 30 drops/min. If BP still not well-controlled despite at
maximum dosage, to consult Specialist.
Syringe pump
iv Labetalol 200 mg in 50 mls N/Saline, start at 20 mg/h (or 4 mls/h) and increase
every 30 min, stop infusion if rate exceed 150 mg/h (or 30 mls/h)).
13. TREATMENT FOR HYPERTENSION
Exact level BP at which to start treatment is controversial, but generally
treat if SBP > 140 – 160 mmHg and DBP > 90 – 110 mmHg.
Treatment is mandatory if BP is ≥ 160/110.
Oral α-methyldopa (longest safety data – preferable especially during 1st and
2nd trimester) and labetalol (late 2nd and 3rd trimester, if not
contraindicated) are the first line of treatment, followed by Nifedipine.
Addition of another anti-hypertensive should only be done after the first
antihypertensive has been maximized.
14.
15. ANTEPARTUM HEMORRHAGE
Definition: Bleeding from the genital tract after 22 weeks of pregnancy to
delivery of foetus
Common Causes :
Placenta praevia
Abruptio placenta
Local causes
Indeterminate APH
DO NOT PERFORM VE / SPECULUM EXAMINATION UNTIL YOU HAVE EXCLUDE
PLACENTA PRAEVIA
16. MANAGEMENT
RESUSCITATION
-estimated amount of blood loss
Mild : 2 pads soaked or 200ml or less
Severe : > 2 pads soaked or > 200ml.
Mild APH - 1 IV line and GXM 2 units of blood
Massive APH - 3 IV lines and GXM 4 units of blood
-use branula size 16 and below
-transfuse immediately and accordingly
Oxygen 7L/min via mask.
CBD insertion – if indicated, monitor urine output.
Quantify bleeding objectively by
using these measurements:
1 pad = 125ml,
1 gallipot = 250ml,
1 kidney dish = 1Litre,
1 sarong = 500ml.
17. MANAGEMENT
B. Blood investigation
Hb, platelet, BT, CT, BUSE, PT, APTT, INR, GXM
C. Perform Ultrasound Scan
D. Monitoring -close observation of mother (BP, PR, Pad Charts) and foetus
(CTG).
E. Definitive treatment - Decision on clinical diagnosis and proceed
accordingly
DO NOT USE TOCOLYTIC IN THE PRESENCE OF PER-VAGINAL BLEEDING
18. PLACENTA PREVIA
Features of bleeding: painless, recurrent, always revealed
General condition: Proportional to blood loss
Abdomen: soft, relaxed, malpresentation is common, presenting part high
Foetal heart sound: usually present
Admission and Referral
All placenta praevia major should be managed as in patient from 32 weeks
onwards.
All bleeding placenta praevia should be admitted at any gestational age.
19. Abruptio Placenta
Features of bleeding: painful, revealed, concealed or mixed
General condition: out of proportion in concealed type
Abdomen: tense, tender and woody, head engaged
Foetal heart sound: usually absent particularly in concealed type
Common presentation: preterm 30-35 weeks with elevated BP
20. POST PARTUM HEMORRHAGE
DEFINITION: Bleeding from or into the genital tract of > 500ml following
delivery
1. Type Primary PPH - <24 hours after delivery
2. Secondary PPH - >24 hours after delivery
Causes of Primary PPH(4T‟s)
i. Tone; Atonic Uterus
ii. Trauma :Trauma to genital tract
iii. Thrombin: Coagulation defects
iv. Tissue: Retained products of conception
21. Referred Cases From Home Delivery/ District Hospital
1. Assess blood loss
2. Check vital signs
3. No exploration to be done until blood is transfused (at
least 2 units of blood). Proceed to OT for exploration under
GA after transfusion.
4. MO in district hospital should transfuse 1-2 litres of blood
first in their hospital in all cases of home/ hospital delivery
before transferring the patient.
5. If patient are still oozing after exploration, transfer
patient to hospital with Specialist and trigger Red Alert
System
22. 6. Prophylaxis against PPH
Gravida 5 and above, twin pregnancies, polyhydramnios and prolonged 1st and 2nd
stage should have IV drip with 40U of pitocin/ pint DS at 20drops/min for 6 hours
after 3rd stage of labour.
7. If local causes, catch bleeder and pack vagina with roller gauze/ pads (up
to 3 pads rolled up into vagina). – remember to inform referral hospital.
8. All cases of PPH > 800mls or if BP low with systolic < 90, pulse rate >
120/min, please alert Specialist stat via Red Alert.
23. MATERNAL COLLAPSE IN PREGNANCY AND
THE PEURPERIUM
Maternal collapse is defined as an acute
event involving the cardiorespiratory
systems and/or brain, resulting in a
reduced or absent conscious level (and
potentially death), at any stage in
pregnancy and up to six weeks after
delivery.