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Following the first meeting of the International Confederation of Countries Advisory Council meeting in Beijing last year, it has become evident that the concept of HVP Country Nodes has evolved from their initial definition as repositories of genetic variation information in single countries. There appears to be a desire amongst Human Variome Project Consortium members that HVP Country Nodes should be seen as a nucleus for activities relating to human genetics within a country. With this view in mind, the Human Variome Project International Coordinating Office has prepared a new model for HVP Country Nodes. This model was presented (see http://www.slideshare.net/variomeproj/a-suggested-model-for-hvp-country-nodes) at the 4th Biennial Meeting of the Human Variome Project Consortium to initiate discussion and debate during this panel session. It is a “straw man” model, meant to be knocked down, dissected and discussed, in the hopes of building a better, more representative model.