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Volume 14, Issue 2 , Pages 132-135, May 2008
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Adverse effects of phytoestrogens on reproductive health: A
report of three cases Article Tools
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Ashadeep Chandrareddy, M.D, Ozgul Muneyyirci-Delale, M.D , Samy I. McFarlane, M.D, Omar M. Murad, M.D
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Background (15) Cited in Scopus
Phytoestrogens have been thought to have favorable effects on women's health and perhaps in offsetting cancers. The Export Citation
possible adverse effects of phytoestrogens have not been evaluated.
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Cases
Abnormal uterine bleeding with endometrial pathology in three women was found to be related to a high intake of soy
products. The first woman had postmenopausal bleeding with uterine polyp, proliferative endometrium and a growing
leiomyoma. The second woman presented with severe dysmenorrhea, abnormal uterine bleeding, endometriosis and
uterine leiomyoma not responding to treatment. The third woman with severe dysmenorrhea, abnormal uterine bleeding,
endometriosis and uterine leiomyomata presented with secondary infertility. All three women improved after withdrawal of
soy from their diet.
Conclusion
Additional information on phytoestrogens is necessary to ascertain their safety before they can be routinely used as
supplements.
Keywords: Phytoestrogens, Soy, Isoflavones, Endometeriosis, Leiomyoma, Abnormal uterine bleeding
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PII: S1744-3881(08)00017-0
doi:10.1016/j.ctcp.2008.01.002
© 2008 Elsevier Ltd. All rights reserved.
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Volume 14, Issue 2 , Pages 132-135, May 2008
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