Novo Informatics Presentation

1. Accelerate Drug Discovery with
Novo Informatics
www.novoinformatics.com
Incubated : IIT Delhi
© 2012 Novo Informatics

2. Why CADD?
 Faster, Cheaper and Reliable
 Computational studies are helpful to answer questions
which remained unanswered from experimental
methods
 CADD introduces more exciting and intuitive approach
to Drug Discovery
 Computational scientists now work shoulder-to-shoulder
with Experimentalist
 CADD has become a part of every pharmaceutical
Research and Development unit
© 2012 Novo Informatics

3. Who We Are
 A leading Drug Discovery startup incubated in IITD
 We believe in innovation, speed and excellence in
execution
 Our mission is to achieve our objectives in an
environment of transparency, honesty, and courtesy
towards our clients and employees
 We are committed for the betterment of human health
and their quality of life
 We are currently looking for global partners and
collaborators
© 2012 Novo Informatics

4. Our Expertise
 Analysis and modeling of target protein structure
 Active site prediction & Virtual screening
 Fragment-based design
 Hit-to-lead optimization
 Prediction of off-target susceptibility
 Customized chemical library design (library enumeration)
 ADMET Prediction
 Custom Molecule Synthesis
 Library synthesis
 Peptide Synthesis
© 2012 Novo Informatics

5. Our Discovery Pipeline
Target Selection Single target
Dual target: polypharmacology
Libraries :
Screening Chemical Library Fragment library(Bioactive)
Focused library & targeted library
Synthetically approved molecule library
Diverse Scaffold identification
Prioritize Hits Off target Susceptibility
Molecule synthesis
BioAssay based Identification of Hit
Hit Optimization Hit evolution
Fragment expansion
Hit-To-Lead Iterative Cycles (Validations)
© 2012 Novo Informatics

6. Our Asset: chemical libraries
 A comprehensive collection of
multi-million drug-like Chemical Libraries
commercially available
compounds available for direct
screening(million+)
 A collection of nearly 5000
unique fragments
 Separate libraries for
Proteases, Kinases, Ion-
Customized
channels, Phosphatases, transp Fragments
orters etc. Target Specific
 American standards approved Open
commercial libraries
© 2012 Novo Informatics

7. Technology
Active Site
Selection Module
Unique Molecule
libraries
DRUGONOV
Customized
filtering
Optimized package
for ADME predictions
© 2012 Novo Informatics

8. Unique Disciplines
 Considering receptor plasticity by utilizing Multiple
Receptor Conformation based Virtual High-throughput
Screening
 Polypharmacology: designing compound which can work
against more than one target. A method suitable for
complex diseases such as Alzheimer’s Disease
 Library synthesis: Synthesizing compounds as well as
library of analogues for experimental purpose
© 2012 Novo Informatics

9. Facilities
 Computing Engine
Software Purpose
ProteoNov Protein structure prediction
DRUGONOV A complete screening package
BAPPL Binding affinity prediction
 Computing power: The Supercomputing Facility for
Bioinformatics & Computational Biology (SCFBio), IIT Delhi
 Experimental set up for undergoing compound synthesis and
validations
© 2012 Novo Informatics

10. Services
• Target Optimization
• Screening & Bioassay based Hit Identification
• Hit to Lead Optimization(Iterative cycles)
• Molecule Synthesis
• Peptide Synthesis
• Phyto/Plant Chemistry
© 2012 Novo Informatics

11. Working • Exchange -Confidential Agreement s
Methodology Disclosure
•
•
Consulting Agreements
Disclosure of invention/Discovery
• Target – Analysis
• Expert Opinions (Client side)
Clarify • Mode of research
• Target – Analysis
Simplify • Expert Opinions
• Suitable Methodology
• Possible opinions
• Implementation
• Interim reports
Closure • Result reports to Client
© 2012 Novo Informatics

12. Clients
MBiotech, UK
Project– Molecular Designing & Validations
Status–Successfully completed
Adhaere Pharmaceuticals, USA Ellis Fischel Cancer Centre, Columbia, USA
Project–Molecular Screening Project–Complete Drug Discovery Project
Status–Ongoing Status–Ongoing
© 2012 Novo Informatics

13. Collaborations
Griffith University
IIT Delhi SCFBIO,IITD Australia
© 2012 Novo Informatics

14. Team
Core Team
Prof B Jayaram : Director & Cofounder
Mr. Sahil Kapoor : Director & Cofounder(Head, Global Business Operations)
Mr. Avinash Mishra : Director & Cofounder(Head, R&D Operations)
Dr. Sharad Gupta : Sr. Scientist (Head, Chemistry Division)
Dr. Braham Prakash : Sr. Scientist ( Chemistry Division)
Scientific Advisors
Dr. Chinmoy De : Prof, School of Biological Sciences [IITD]
Dr. Aditya Mittal : Associate Prof ., School of Biological Sciences[IITD]
Dr. Puneet Kacker : Fellow.[Drug Discovery Dept.], Italian Institute of Italy
© 2012 Novo Informatics

15. Thank You
© 2012 Novo Informatics