This presentation describes ICx\' BioImmobilizationTM technology for use in smart wound dressing product development. ICx is actively seeking partnerships in the wound care field.

1. Applications of ICx Protein-Polymer
Composites:
Wound Care
paul.rohricht@icxt.com ICx BioImmobilization™
Vice President, Commercial Business Development
www.icxt.com

2. About ICx Technologies (NASDAQ: ICXT)
Advanced sensor and technology development company
Core business focus: military, homeland defense, security markets
Founded 2003
25 entrepreneurial teams (companies) located in U.S., UK, Germany
800+ multi-disciplinary workforce. 200+ engineers, 50+ scientists
Broad & diversified technology base: 35+ patents , 50+ filed
Substantial government development funding
2008 Revenues: $175M
Technologies developed within ICx have application outside of
security:
Wound care, in vitro diagnostics, medical devices
We are actively engaged in seeking partnerships to commercialize
products utilizing ICx technology and know-how
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3. ICx-Agentase
Agentase operates as a wholly-owned subsidiary of ICx (Pittsburgh, PA)
Developing low-cost tools for the detection/decontamination of hazardous chemicals
Technical expertise / IP
Applied enzymology
Formulation development
Enzyme-polymer synthesis
Urethanes
– Fabrics – Gels
– Films – Foams
Acrylates
Water-soluble protein-polymer conjugates
– PEG-ylation
– PEG-alternatives
Scaled synthesis
– Bench-top
– Pilot
– Production
Rapid prototyping
Launched commercial products based on our technology platform
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4. ICx BioImmobilization™
ICx BioImmobilization™ Technology
Proprietary immobilization of small molecules, enzymes and other
proteins into a variety of polymers, covalently bonded within a
growing polymer chain
Biomolecules act as co-monomers in polymerization synthesis
Applications
In Vitro Diagnostics
Wound healing: ‘smart’ bandages indicate healing progression, or
can respond and deliver drugs in situ
Medical device coatings: protein-polymer combinations can be pro-
healing or can inhibit (anti-microbial, anti-thrombosis, anti-adhesion)
Proteins can be immobilized within polymer foams and gels directly
(eg., spinal implants)
Versatility
Polymers can be made into sprays, gels, or foams
Pre-polymer material approved by FDA
FDA approved and in use as hydrophilic dressings
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5. ICx BioImmobilization™
Performance
Loading of proteins, enzymes or other molecules into polymer
allows target analytes to be detected at high sensitivity;
Activity and specificity of biomolecules are well maintained for long
periods through tertiary structure stabilization;
Protein environmental and thermal sensitivity are dramatically
reduced;
Dyes can be simultaneously loaded into polymers to provide
colorimetric indication of analyte presence (eg., wound progress
indication);
Covalent incorporation ensures molecules will not leach from
polymers during use.
Experience
More than 100 proteins successfully immobilized;
Multiple commercial products launched.
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6. Applying BioImmobilization™ in healthcare
Applications
In Vitro Diagnostics
Development of an analyte-specific sensor for point-of-care IVD
Partners interested in working with us because of technology
attributes
Siemens
RapidPoint TM
– Stabilization of reagents and proteins
» Shelflife: enzymes and reagents formulated to be stable for years
without any special storage requirements
» Operational: sensors perform reproducibly for long periods of time
» Robust: work well under adverse and variable conditions
Wound Care
Sensors
– Identification
– Qualification
– Quantification
Responsive, functional “smart” sponges, gels, materials, coatings,
dressings
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7. BioImmobilization™ for Improved Wound
Outcomes: advanced ‘smart’ wound dressings
Responsive
Delivery of Actives
Indicator Sensors Remodeling
•Cell number decreases
•Collagen fiber bundle organization
Proliferative
Wound
•Fibroblast number increases
•Myofibroblasts appear
•Connective tissue deposited
•Epithelial cell migration
Lag •Vascularization (angiogenesis)
•Hemostasis
•Inflammatory infiltration
•Cytokine release
Aiba-Kojima, E, et al, Characterization of wound drainage fluids as a source of soluble factors
Time associated with wound healing: comparison with platelet-rich plasma and potential use in
cell culture, Wound Rep Reg (2007) 15 511–520.
Iocono JA, et al, The biology of healing. Oxford University Press, 1998., p.11.
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8. BioImmobilization™ for the development of
‘Smart’ Wound Care Dressings
Potential to synthesize materials that respond to the physiological status
of a healing wound
Analytical dressings
Sensor technology integrated within materials having physical properties of
conventional hydrophilic foam dressings
Bandage changes color in presence of target analytes in wound
– Marker for wound progress / lack of progress
– Indicator of common problems or high bacterial colony counts within a wound
Self-decontaminating dressings
Utilize “decontaminating” enzymes to respond to detected high colony counts by
producing disinfectants
Smart erodible dressing materials
Wound responsive
Potential delivery vehicle for actives
– Anti-microbials
– Large MW drugs
– Protein fragments
Actively seeking partnerships to exploit these concepts
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9. Dressings that illustrate conditions in a healing
wound
ICx has a long history of developing enzyme-containing polyurethanes for
use as highly specific and sensitive chemical sensors
The same approach may be used to produce ‘indicator dressings’ (either
visual or facilitated) for the assessment of the following conditions within a
wound (partial list)
pH
MMPs
Color response to increasing
MMP / TIMP balance
amounts of analyte
Small bacterial Large bacterial
Microbial colony counts load load
Phospholipase A (activates platelet aggregation in an acute wound)
NADPH-oxidase (its absence suggests risk of chronic infection)
Lysyl oxidase (catalyzes collagen crosslinking in late stage wound healing)
NOx
Growth factors and cytokines mediated by kinases
HGF, IGFs 1 & 2, IFN-γ, IL-6, VEGF, KGF (FGF-7)
b-FGF, EGF, PDGF, TGF-α, TNF-a, IL-1, TGF-β
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10. Summary
ICx has proprietary technologies that can be directly
applied to wound care, IVD, and medical device space
BioImmobilization™ technology is able to incorporate active
biomolecules and small molecules within hydrophilic
biocompatible polymer foams, gels, and sprays
We can use this technology to make ‘smart’ wound
dressings to potentially speed the wound healing process
Analytical dressings
Smart decontaminating dressings
Responsive dressings
ICx is actively seeking partnerships in wound care to exploit
this know-how
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