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Breastfeeding domeperiodne
- 1. The association between domperidone and ventricular arrhythmia
in the postpartum period.
Smolina K1
, Mintzes B2
, Hanley GE3
, Oberlander TF4
, Morgan SG5
.
Author information
1
School of Population and Public Health,University of British Columbia,Vancouver, BC. kate.smolina@ubc.ca.
2
Faculty of Pharmacyand Charles Perkins Centre,Universityof Sydney, Australia.
3
Departmentof Obstetrics and Gynaecology, University of British Columbia,Vancouver, BC.
4
Child & Family Research Institute,University of British Columbia,Vancouver, BC.
5
School of Population and Public Health,University of British Columbia,Vancouver, BC.
Abstract
PURPOSE:The aim of this study is to examine the relationship between domperidone (commonly used
off-label for lactation stimulation), ventricular arrhythmia and all-cause mortality during the postpartum
period.
METHODS: This is a retrospective, population-based cohort study of all women with a live birth
between 1 January 2002 and 31 December2011 in British Columbia, Canada. Cox proportional hazards
models, yielding hazard ratios (HRs), were used to estimate the risk of hospitalization for ventricular
arrhythmia associated with domperidone exposure within six months postpartum.
RESULTS:The study population consisted of 225 532 women with 320 351 live births. There was only
one death during the six-month postpartum period among the study population, and thus we did not
perform any analyses of all-cause mortality. We identified 21 hospitalizations for ventricular
arrhythmia. Adjusting for age, smoking and prior history of ventricular arrhythmia and cardiovascular
disease, the risk of ventricular arrhythmia hospitalization was approximately double among those
exposed to domperidone, but the results were not statistically significant (HR = 2.25, 95%CI 0.84-
6.01). Adjustment for body mass index in the 74% of women for whom it was known further reduced the
association (HR = 1.69, 95%CI 0.48-5.96).
CONCLUSIONS: We found a possible association between exposure to domperidone and
hospitalization for ventricular arrhythmia among a cohort of women who have recently given birth. Future
studies are needed to confirm this association.
Copyright © 2016 John Wiley & Sons, Ltd.
