Insulin regulation of secretion

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 Blood glucose regulates insulin secretion
 Insulin regulates blood glucose

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2



Direct feedback effect on pancreatic beta cells
▪

When plasma glucose ↑
▪

▪

When plasma glucose ↓
▪



Insulin secretion ↑

Insulin secretion ↓

Great precision
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3

Pancreas

Blood
glucose

Insulin

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4



Insulin regulates blood glucose
 Glucose production by the liver
 Uptake and utilization in peripheral tissues
▪ Muscle
▪ Adipose tissue
▪ Liver

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5



80 to 90 mg/100 ml
 Rate of insulin secretion is low



Plasma glucose < 75 mg / dl
 Insulin secretion inhibited

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6



> 75 mg/dL
 Stimulate insulin synthesis and insulin secretion



Blood glucose > 100 mg/100 ml
 Insulin secretion rises rapidly

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7



Glucose between 300 and 500 mg / dl

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Diabetes mellitus

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