By Denny WatkinsPublished November 10, 2013The news that comes out of research universities and hosp...

1. 10 medical breakthroughs that sound like science fiction
By Denny Watkins
Published November 10, 2013
The news that comes out of research universities and hospitals often sounds too hopeful: Here's a
gene click here. that maybe, could potentially end obesity. This newly discovered protein pathway
might sort-of, some day cure cancer. Do any of the thousands of studies published each year really
result in a meaningful change in someone's life?
Here's your answer: For the eighth consecutive year, the Cleveland Clinic has selected 10
technologies and discoveries that are already making an impact. "We look for innovations that are
somewhat disruptive, so a new medication isn't just a little better, it's substantially better," says Dr.
Michael Roizen, who headed the panel of 30 medical professionals that selected this year's finalists.
Check out the technology of the future that's already on our doorstep.
The Bionic Eye
The "Argus II" takes a video signal from a camera built into sunglasses and wirelessly transmits that
image to implants in the retinas of people who have lost their vision. Though it's been available in
Europe since 2011, the U.S. Food and Drug Administration (FDA) only approved the eye earlier this
year. "This really is like Star Trek technology," Roizen says.
The system isn't perfect. It lets a blind person regain basic functions like walking on a sidewalk
without stepping off a curb, and distinguishing black from white socks, but only lets you read one
giant-sized word at a time on a Kindle. Plus, as the retina itself heals over the implant, the quality of
vision decreases. The Argus II is currently only approved for people who have lost their sight from
retinal pigmentosis--which affects 1 in 4,000 Americans. But the technology could soon help the
more than 1.75 million people who suffer from macular degeneration. (The eyes are the window to
the...mind? Find out what insights your eyes have on the brain.)
The Cancer Gene Fingerprint
Not all cancers are equally lethal--cancer in your prostate means a longer survival rate than a
malignancy in your brain, for example. But even prostate cancer comes in multiple flavors ranging
from manageable to very bad. By analyzing the mutated genome of a tumor, doctors can now
pinpoint whether a cancer is sensitive to a certain chemotherapy, or one that doesn't respond at all
to current treatments. Knowing the subtype might mean jumping directly to a clinical trial that could
save your life. (Discover 8 stealth strategies to Cancer-Proof Your Body.)
The Seizure Stopper
For the 840,000 epileptics suffering from sudden, uncontrollable seizures, the NeuroPace is like "a
defibrillator for your brain," Roizen says. The system includes sensors implanted in the brain that
can spot the first tremors of an oncoming seizure. Then it sends electrical pulses that counteract the
brain's own haywire signals, stopping the seizure in its tracks. Even more impressive: The
NeuroPace can be fine-tuned by doctors based on its performance. In the first year it was available,
seizure episodes were reduced by an average of 40 percent--but 2 years later, they dropped by 53

2. percent. (Know what symptoms warrant a trip to your doctor: Learn the 7 Pains You Shouldn't
Ignore.)
The Hepatitis Cure
Until recently, treatment for hepatitis C fell into the good-but-not-great category, with only around
70 percent of patients being cured. And that was after as much as 48 weeks of a strict anti-viral drug
regimen, including injections of interferon--which causes a number of debilitating side effects. But
the new drug Sofosbuvir is a much more potent killer of hep C, with success in as many as 95
percent of patients. Even more, the medication only has to be administered for 12 weeks, sans
interferon injections.
The Anesthesiologist's iPad
Surgeons may get more glory, but anesthesiologists probably play the most vital role in keeping you
alive during surgery. They're the last face you see before you're put into a medicated sleep so deep
you don't even notice that your body is being peeled open. Between keeping track of your heart rate,
breathing, and brain functions, an anesthesiologist also needs to be familiar with the ins and outs of
the procedure so they can adjust sedatives and painkillers--without causing complications.
The new "perioperative information management systems" include software on touchscreen-enabled
computers that can warn doctors if things are going south, keep track of the surgeon's workflows,
and document every step of the procedure. All are essential when surgeries last up to 16 hours and
docs need to pass the reins to a fresh pair of eyes.
The Fecal Transplant
The idea of taking someone else's poop and giving it a new home in your own colon may sound
repulsive, but the treatment has proven remarkably effective in curing infections of C. difficile--a
nasty bacteria that kills 15,000 people each year. Take heart: The digested food waste in feces isn't
itself the cure. You're simply gaining some of the helpful bacteria living in the donor's gut--like a
farmer choosing the hardiest crops to seed next year's fields.
"The bacteria produce proteins that are involved in a lot more diseases than we realized," says
Roizen. Still grossed out? Researchers in Canada have developed a method to deliver just the
bacteria--no feces--via an oral pill, skipping the need for a poo enema.
The Heart-Saving Hormone
Around one in four people who are hospitalized for heart failure don't last much longer than a year.
But a new drug called Serelaxin has upped the odds of survival by as much as 37 percent, according
to a University of California, San Francisco study. It's a synthetic version of the hormone relaxin,
which is produced by pregnant women to help with the increased stress carrying a fetus places on
the heart. "It not only opens up your blood vessels to supply your organs oxygen, but it has anti-
inflammatory properties," Roizen says. Serelaxin's life-saving potential is profound enough that in
June, the FDA dubbed it a "breakthrough therapy," putting it on a faster track for approval in
hospitals.
The Robot Doctor
If you're undergoing a colonoscopy, you'll want something to take the edge off (for obvious reasons).

3. But even a light sedative to help you snooze while doctors spelunk your butt requires the presence of
an anesthesiologist--which translates to $1 billion in additional medical expenses, according to a
study in the Journal of the American Medical Association.
Enter the Sedasys: a computer with an attachment on the IV that meters out the correct amount of
sedative and monitors vitals. It even includes an earpiece to wake patients up if necessary. That
allows docs to administer "light to moderate" sedation on their own, with a single anesthesiologist
supervising multiple patients. "If Michael Jackson's doctor had this and knew how to use it, then
Michael Jackson would still be alive today," says Roizen.
The Better Heart-Attack Risk Test
Today you get a cholesterol test to assess your risk of heart attack, but soon you'll be more worried
about your trimethylamine N-oxide (TMAO) levels. Why? People with the highest levels of TMAO in
their blood have 2.5 times the risk of a heart attack compared to those with the lowest levels,
according to a recent study in the New England Journal of Medicine. TMAO is a compound produced
by intestine bacteria--yep, the same ones involved in fecal transplants--after you eat choline, which is
found in eggs, red meat, and dairy.
Once in your bloodstream, TMAO accelerates the process of cholesterol forming into plaques in your
arteries. "We're learning why red meat is hazardous, and what could be done to avoid that hazard,"
Roizen says. Beyond simply avoiding red meat, preventive steps could include probiotics or
medications that pinch off TMAO-producing pathways. (Cholesterol is so 2012. Meet today's artery
enemy with The New Heart Threat.)
The Precision-Guided Cancer Treatment
The difficult goal in any cancer treatment is to kill the tumor while leaving healthy cells alone.
Recently, a better understanding of what makes cancer cells tick has allowed scientists to develop a
class of drugs that pinpoint a weakness in cancer's uncontrolled growth. For example, in lymphomas
and leukemias, scientists have determined that the growth is controlled by a protein called Bruton's
tyrosine kinase (BTK). After years of experimentation, doctors developed a new drug called Ibrutinib
that blocks BTK.
A pair of studies in the New England Journal of Medicine this summer found that the oral pill helped
71 percent of chronic leukemia patients and 68 percent of patients with a type of non-Hodgkins
lymphoma. Most importantly, Ibrutinib killed off the lymphoma while leaving the rest of the immune
system alone. "Hopefully this will lead to a whole new class of drugs that will be cancer cell-
specific," says Roizen. (When you get the worst news of your life, seek out one of The Best Cancer
Hospitals in the U.S.)