LEUCEMIA MIELOIDE CRONICA

LEUCEMIA MIELOIDE CRONICA DIAZ SILVA VICTOR MD HEMATOLOGIA CLINICA

OBJETIVO ,[object Object],[object Object],[object Object]

[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

INTRODUCCION ,[object Object],[object Object],[object Object],[object Object],[object Object]

CROMOSOMA Phy ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Fardel S. NEJM 1999;341:164-172

DIAGNOSTICO ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],NCCN. Practice Guidelines in Oncology. V.3.2008

Muestra de sangre periférica con un incremento de la serie mieloide y precursores, así como basófilos (flecha).

Muestra de sangre medular donde se evidencia un incremento de las tres series hematopoyeticas, a predominio mieloide.

Técnica FISH: gen bcr en rojo y abl en verde. En la figura de la izquierda un patrón normal y en la figura de la derecha se evidencia patrón bcr/abl - Phy (+)

[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

FASES ,[object Object],[object Object],[object Object],[object Object],NCCN. Practice Guidelines in Oncology. V.3.2008

FASES ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Jaffe ES, et al. WHO Clasification of Tumors. IARC press: 2001

FASES ,[object Object],[object Object],[object Object],[object Object],Jaffe ES, et al. WHO Clasification of Tumors. IARC press: 2001

TRATAMIENTO ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],NCCN. Practice Guidelines in Oncology. V.3.2008

TRATAMIENTO ,[object Object],[object Object],[object Object],[object Object],[object Object],O`Brien SG, et al. NEJM 2003; 348: Drucker BJ, et al. NEJM 2006; 355:2408-2417

NCCN. Practice Guidelines in Oncology. V.3.2008

Tomado de Goldman JM. Blood 2007; 110:2828-2837

Tomado de O`Brien SG. NEJM 2003; 348:994-1004 Tomado de Drucker BJ. NEJM 2006; 355:2408-2417

TRATAMIENTO ,[object Object],[object Object],[object Object],[object Object],[object Object],Quintanas-Cardenas A, et al. Blood, 2007; 109:497-499

LEUCEMIA MIELOIDE CRONICA

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LEUCEMIA MIELOIDE CRONICA