2. DKO P58: 1639 P58 male, T bili 7.9, weight 25.80gms CFDA CK19 Hilar ducts typically with good CFDA co-stain Multiple areas in periphery with disorganized CK19 positive cells not CFDA positive Pictures intralobular to periphery
3. DKO P58: 1540 P58 male, T bili39.7, weight 13.11gms, very ill appearing CFDA CK19 Much fewer areas of disorganized CK19 cells Some hilar ducts with poor CFDA stain Overall, very limited CFDA Hilar duct negative with small duct adjacent postive for CFDA
4. P70 HNF-6 KO CFDA CK19 Normal All ducts with CFDA No ducts without CFDA
5. P70 NICD/HNF-6: 1575 CFDA CK19 Most well formed ducts positive for CFDA Multiple areas along periphery and hilum without CFDA positive staining, mostly if associated with areas of disorganized CK19+ cells
6. P70 NICD/HNF-6: 1876 CFDA CK19 Most well formed ducts positive for CFDA Multiple areas along periphery and hilum without CFDA positive staining, mostly if associated with areas of disorganized CK19+ cells
