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1. Intrauterine Insemination (IUI)
IUI has become the first line management in infertility. It is a simple technique that involves
the deposition of a washed semen sample into the woman’s uterus around the time of
ovulation. The rationale is to increase the density of both eggs and sperm near the site of
fertilization. This increases the likelihood of pregnancy. Therefore, it has many benefits:
It is done at the optimal time around the rupture of the egg.
It overrides defects in the vagina and cervix eg vaginal infections
It ensures the deposition of sperms at the correct place.
It involves the use of the best washed, motile sperms in a sample.
It can be carried out with a fresh or a frozen sample.
2. IUI with a frozen sample gives a lot of flexibility to couples who lead a very busy life and
cannot be together because of their careers. Semen samples of such husbands can be frozen
and used whenever the wife is wanting to undergo an IUI cycle in her husband’s absence. The
success of an IUI cycle however, depends on many factors – most importantly the doctors
understanding of the patient’s problem, the individualisation of therapy and the cycle
management.
3. Prerequisites For An IUI
You should be ovulating. If you are not, your doctor will give you some medication in order to
ovulate.
Your tubes should be open. This is checked by doing an Xray or U/S or Laparoscopy.
Your husband’s sperm sample should be normal or minimally subfertile. In case of severe
problems some couples opt for IUI with donor sperms or ICSI.
4. How is an IUI Done ?
The man provides a semen sample on the morning of insemination. This sample is prepared
and then inserted through the woman’s cervix and into the uterus. This is done through a thin
plastic catheter. The procedure takes place in our clinic. It is relatively painless. Patient is kept
in bed for some time.
IUI is a relatively simple, non-invasive, cheap & easily repeatable procedure. However, careful
selection of patient is important.There is good evidence in the literature in favor of IUI as a
cost-effective treatment for unexplained and mild, moderate male factor sub fertility.
5. Although it may take relatively more treatment cycles to achieve pregnancy, there are
considerable advantages to the patient in terms of risk / benefit ratio and financial cost
as compared with other ARTs. Failure of 3-4 trials of IUI is an indication for IVF.
We monitor the woman’s ovulation with home ovulation predictor kits and clinic
ultrasounds and blood tests. We monitor her for any signs of adverse effects of fertility
drugs. We also give the woman a hormone injection of human chronic gonadotropin
(hCG) to regulate ovula.