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- 1. www.ppscreeningcentre.com Pivot ParkOssVan target tot markt 25-Sep-2014 Helma Rutjes
- 2. Contents •Pivot ParkLife Sciences Community •Pivot Park Screening Centre •Organisatie •Mogelijkhedenvoorsamenwerkingen •ELF
- 4. Opening Oss LifeSciences Park 2012
- 5. Voornametrend in innovatieveentrepreneurshipwereldwijd! Faciliterenvan open innovatie Pivot Park Gesloteninnovatie Open innovatie Van gesloten… •Solo-creatie •Transacties •IP legaldrive •Academischresearch middelsfondsenvanuitindustrie •Grote bedrijvenbepalenmarkttoegangvoorinnovatie … naaropen innovatie: •Co-creatie •Netwerk/Relationships •Entrepreneurial drive •Commerciele& Academischeresearch samenwerkingen •SMEs versnellenmarkttoegangin innovatie
- 6. Pivot Park OrganisatieChart ELF project management Screening manager Screening operations Assay development Assay Dev manager CSO CEO CFO COO CCO Business Development EHS management Facility management Account management
- 7. Pivot Park Analytics HTS uHTS Compounds Pilot Plant Animal facilities Lab & Office facilities Unique Facilities, Equipment, Knowledge and Approach •Fully equipped labs •Open Access labs •Flex labs •Nuclear Magnetic Resonance •Liquid Chromatography •Mass Spectrometry •Open Access HTS •Flexible uHTS •Hit / Lead optimization •Up to 10 kg •GMP standard •Small molecules •Hosted by BioXpert
- 8. Pivot Park Community(September 2014)
- 9. 14-PPALG0055 Pivot ParkCommunity Interactome2013
- 10. Focus op vroegestadiamedicijnontwikkeling Target ID Hit / Lead discovery Lead Optimization Pre clinical development Clinical phase I Clinical phase II Project management, Drug dev. Plan Suppliers: Pivot Park Based bedrijvenplus anderen Partners Preferred suppliers Top academenresearch partners High throughput Screening PPSC High content Screening NKI HubrechtInst Univ. Nijmegen Univ. Leiden Partner per indicatie BioXB.V. BioTB.V. Partners Core focus op ontwikkelingsfase
- 11. Pivot Park, 25juni2014 Pivot Park 2.0 concept
- 12. Pivot Park 2.0 Uitbreiding faciliteiten: state-of-the-art pilot plant en laboratoriumfaciliteiten
- 13. Contents •Pivot ParkLife Sciences Community •Pivot Park Screening Centre •Organisatie •Mogelijkhedenvoorsamenwerkingen •ELF
- 14. PPSC: Uw partnervoor Screening 30-9-2014 Screening faciliteiten Automatiserings -en assay development specialisten Data processing Compounds
- 15. 1995 2000 2005 2010 2015 IntroductieMTS & HTS Biochemischeencellulairescreening ASPIRE: Geintegreerdin-vitro screening platform uHTS: capaciteit& miniaturisatie Sluitingresearch @ Oss NieuweSME 2012 Systeemaanname& overdracht2012 1stHTS in april2013 Screening Historiein Oss
- 16. IndrukwekkendegroeibinnenPPSC 0 20 40 2012 2013 2014 •Opening Pivot Park •Nieuwrobot systeem •2 fte •Volledigoperationeel •Start van ELF •18 fte •13 HTS •Uitbouwensamenwerkingen •HCA enFLIPR •18+ fte •30 HTS verwacht 2012 2013 2014 #HTS
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- 18. State-of-the-art Equipment enWorkflowsconsistenteenhogekwaliteitdata
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- 20. MogelijkhedenbinnenPPSC •Assay ontwikkeling •Celkweek •Sample handling •Screening (Low, medium en high throughput) •Biochemische en cellulaire assays(High content) •Automatisering van in-vitroexperimenten •Optimalisatie en validatie van geautomatiseerde protocollen •Geautomatiseerde data processing 30-9-2014 High Throughput Screening Facility
- 21. Velesamenwerkingengestart •Cancer DrugDiscovery Initiative •NederlandsKankerInstituutenLeiden Universiteit •Gezamenlijkprogrammaom klinischekandidatenin oncologieteontwikkelen •Academischesamenwerkingenin Europa •C.elegansscreening/Horizon2020 aanvragen •Pivot Park bedrijven •NTRC screening projecten •Lab vooropen innovatie •Vroegeresearch samenwerkingenmet meerderebedrijven •European Lead Factory •30 partners, 7 EFPIA •120 HTS programma’sin 5 jaar
- 23. Disclaimer 23 DearReader, Only the official and formally signed contractual documents in relation to the EU Lead Factory (the Project Agreement, Grant Agreement, the Description of Work, and Third Party Access Agreements) have a binding value in relation to the subject matter covered in these slides. Any information contained in these slides is not binding upon the parties and can in no event be used to interpret or complement the formally signed contractual documents referred to above. The EU Lead Factory Team
- 24. Made Possible by 24 EU Lead Factory combines innovationof Academia, agility of SMEs, and experienceof Pharma and fundingfrom
- 25. Medicijnenonderzoekende waardeketen 25 Waardevan compound Target Hit finding Hit to lead Lead series Phase I & II Phase II & registrate Sales €€ Years 3 5 6 8 11 13 25
- 26. A Large-Scale ControlledExperiment 26 Shared Useof Compound Collections Crowd- SourcingInnovation from Biology & Chemistry Partneringof Public Target Programmes Value Generation from Publicly- funded Initiative
- 27. Collaborative Drug Discovery 27 Molecular Targets European Screening Centre EFPIA contribution (>300.000 cpds) Public contribution (up to 200.000 cpds) Joint European Compound Library Compounds uHTS Compound logistics Hit triage Medicinal Chemistry
- 28. Target Programme Collaboration 28 EU Lead Factory Experts supporting and pavingthe way You in the lead Flying start drug discovery research
- 29. Assay development /uHTS 29 0 2 4 6 8 10 0 1 2 3 4 5 6 0 5 10 15 384-wells 1536-wells 0 5 10 15 20 biochemical cellular Number of platesscreened per day Technologiesprogrammes Plate format Assay typeprogrammes
- 30. Publieke Target Programma’sVoortgang 30 Submitted 68 Accepted 31 Assay development 24 uHTS 14 Hit Follow-up 13 QHL 4 Molecular Targets Sept 2014
- 31. www.ppscreeningcentre.com ●31 Eenmooietoekomst! 30-9-2014 High Throughput Screening Facility •Oss herbergtHETEuropeseScreening Centrum •Europesefunding tot jan.2018 •ELF is eeninnovatiefbusiness model voorPharma onderzoek •Samenwerkingin consortium leidttot nieuweopportunities
- 32. www.ppscreeningcentre.com ●32 BusinessOpportunity Pivot Park •Perfectelocatie, goedbereikbaar •Goedeatmosfeer: community •Starterspakketvoorlabinrichting •Van target tot markt •Van starter tot middelgrootbedrijf Pivot Park Screening Centre •Kwaliteit •Efficienteenvolledigeautomatisering •Flexibeleklant-georienteerdeservice •Samenwerkingen: improvement cycle •KansenvoorELF assays
- 33. www.ppscreeningcentre.com Molenstraat 110• 5342 CC Oss • The Netherlands • +31 (0) 412 71 25 11 Bedankt voor uw aandacht!