Collagen was the first FDA-approved wrinkle filler in 1981 but was replaced by better, safer products starting in the early 2000s. The history of injectable treatments for facial rejuvenation includes both wrinkle fillers containing substances to fill wrinkles and provide volume with results often seen immediately lasting 6 months to several years, as well as wrinkle relaxers containing neurotoxins to relax muscles causing wrinkles with results developing within days to a week lasting 3 to 6 months. Popular products throughout this history include Zyderm, Zyplast, Hylaform, Cosmoderm, Captique, Fibrel, Evolence, Prevelle Silk, and Dysport.

1. THE HISTORY
OF INJECTABLES
T H E R E VOLUTION IN FACIAL REJUVENATI O N
Injectable treatments such as wrinkle fillers & wrinkle relaxers have
revolutionized facial rejuvenation. Collagen was the first FDA-approved filler in
1981, but was soon replaced with better, safer, longer-lasting fillers in the early
2000s. Here's a look at the history of these products.
ZYDERM
®
ZYPLAST
1981
®
1985
Hylaform
1988
Cosmoderm
®
2003
2003
e l evess
TM
2004
2006
EVOLENCE
2009
®
PREVELLE® SILK
2008
2008
2006
2011
2011
-L
V O L U M A XC
TM
wrinkle relaxers
2013
WRINKLE RELAXERS
TM
2006
2006
2009
wrinkle fillers
2002
®
2004
2004
Captique
FIBREL
®
2012
WRINKLE FILLERS
• Products relax muscles that
cause wrinkles
• Products fill wrinkles and
provide volume
• Products contain a purified
form of neurotoxin
• Products contain a variety of
substances
• Results develop within a few
days to a week
• Results often seen immediately
• Results last from 3 to 6 months
• Results last from 6 months to
several years, based on product
Infographic by:
Sources:
http://www.fda.gov/MedicalDevices/ProductsandMedicalProcedures/CosmeticDevices/WrinkleFillers/ucm227749.htm