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University of Cádiz. Spain. 
1Preventive Medicine and Public Health Area. 
2Department of Neuroscience, Pharmacology and Psychiatry, CIBER of Mental Health, CIBERSAM, Institutode SaludCarlos III. 
Mood and sleep disorders in relation with cognitive deficits in patients with chronic pain. A non-coincidental relationship. Inmaculada Failde1, Begoña Ojeda1, Alejandro Salazar1, María Dueñas1, Juan Antonio Mico2. 
The association between pain and affective disorders is complex. Therefore, it is necessary to know other factors that may affect this relationship. 
In the present study we explored the effect of cognitive function and quality of sleep on affective disorder in chronic pain patients. 
The Mini-Mental State Exam 
Dimension 
Scores 
Temporal orientation 
5 
Spatial orientation 
5 
Registration 
3 
Attentionand calculation 
5 
Remotememory 
3 
Naming 
2 
Repeat 
1 
Stagecommand 
3 
Writingcomplete sentence 
1 
Reading and obeying 
1 
Copythediagram 
1 
Total 
30 
Affective disorders 
Sleep 
Pain Intensity 
Cognitive function 
Instruments 
Hospital Anxiety and Depression Scale (HADS) 
Cutoff 
Anxiety (0-14) 
>10 
Depression (0-14) 
Visual Analogue Scale (VAS) 
0 
1 
2 
3 
4 
5 
6 
7 
8 
9 
10 
No pain 
Worst pain 
MOS Sleep Scale 
SleepProblem 9 Index (0-100) 
Item contents 
Time to fall asleep 
Sleep restlessness 
Enough sleep, feel rested 
Awaken short of breath or headache 
Feel drowsy 
Trouble falling asleep 
Awaken during sleep 
Trouble staying awake 
Amount sleep needed 
0 No impact 
Great impact 100 
Mean (SD) 
N=254 
Age(years) 
47.4 (8.8) 
Pain 
Intensity(0-10) 
6.6 (1.9) 
Duration(months) 
108.5 (97.6) 
Scales 
HADS(0-42) 
17.33 (9.1) 
9 Index MOS(0-100) 
52.4 (21.7) 
MMSE(0-30) 
26.9 (2.2) 
Results 
Neuropathic 
101 (40.9%) 
Fibromyalgia 
51 (20%) 
Types of Pain 
Musculoskeletal 
99 (39.1%) 
63,8% 
29,2% 
43,3% 
32,3% 
0 
20 
40 
60 
80 
Sex (female) 
Depression (>10) 
Anxiety (>10) 
MMSE(≤26) 
Frequencies 
Linear Regression Model 
Variable 
B(ET) 
IC (95%) (inf:Sup) 
P 
Duration(months) 
-.007 (.005) 
(-.017; .002) 
.130 
Intensity (0-10) 
.195 (.253) 
(-.304; .693) 
.443 
History of depression (Yes/No*) 
3.593 (.978) 
(1.667;5.518) 
<.001 
9 Index MOS (0-100) 
.197 (.023) 
(.152; .242) 
<.001 
MMSE (0-30) 
-.925 (.208) 
(-1.335; -.515) 
<.001 
N=254; Adjusted R2=.353 
*Reference category 
Having a sleep disorder, a previous diagnosis of depression and impaired cognitive function were associated with worse results on the HADS scale. 
Chronic Pain 
Sleep and cognitive function disorders are common in patients with chronic pain and represent factors that have a greater impact than the pain itself on their mental health. 
Mean and SD of scalesand pain 
Variables relatedtoHADS scores in chronicpainpatients

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Mood and sleep disorders in relation with cognitive deficits in patients with chronic pain. A non-coincidental relationship.

  • 1. University of Cádiz. Spain. 1Preventive Medicine and Public Health Area. 2Department of Neuroscience, Pharmacology and Psychiatry, CIBER of Mental Health, CIBERSAM, Institutode SaludCarlos III. Mood and sleep disorders in relation with cognitive deficits in patients with chronic pain. A non-coincidental relationship. Inmaculada Failde1, Begoña Ojeda1, Alejandro Salazar1, María Dueñas1, Juan Antonio Mico2. The association between pain and affective disorders is complex. Therefore, it is necessary to know other factors that may affect this relationship. In the present study we explored the effect of cognitive function and quality of sleep on affective disorder in chronic pain patients. The Mini-Mental State Exam Dimension Scores Temporal orientation 5 Spatial orientation 5 Registration 3 Attentionand calculation 5 Remotememory 3 Naming 2 Repeat 1 Stagecommand 3 Writingcomplete sentence 1 Reading and obeying 1 Copythediagram 1 Total 30 Affective disorders Sleep Pain Intensity Cognitive function Instruments Hospital Anxiety and Depression Scale (HADS) Cutoff Anxiety (0-14) >10 Depression (0-14) Visual Analogue Scale (VAS) 0 1 2 3 4 5 6 7 8 9 10 No pain Worst pain MOS Sleep Scale SleepProblem 9 Index (0-100) Item contents Time to fall asleep Sleep restlessness Enough sleep, feel rested Awaken short of breath or headache Feel drowsy Trouble falling asleep Awaken during sleep Trouble staying awake Amount sleep needed 0 No impact Great impact 100 Mean (SD) N=254 Age(years) 47.4 (8.8) Pain Intensity(0-10) 6.6 (1.9) Duration(months) 108.5 (97.6) Scales HADS(0-42) 17.33 (9.1) 9 Index MOS(0-100) 52.4 (21.7) MMSE(0-30) 26.9 (2.2) Results Neuropathic 101 (40.9%) Fibromyalgia 51 (20%) Types of Pain Musculoskeletal 99 (39.1%) 63,8% 29,2% 43,3% 32,3% 0 20 40 60 80 Sex (female) Depression (>10) Anxiety (>10) MMSE(≤26) Frequencies Linear Regression Model Variable B(ET) IC (95%) (inf:Sup) P Duration(months) -.007 (.005) (-.017; .002) .130 Intensity (0-10) .195 (.253) (-.304; .693) .443 History of depression (Yes/No*) 3.593 (.978) (1.667;5.518) <.001 9 Index MOS (0-100) .197 (.023) (.152; .242) <.001 MMSE (0-30) -.925 (.208) (-1.335; -.515) <.001 N=254; Adjusted R2=.353 *Reference category Having a sleep disorder, a previous diagnosis of depression and impaired cognitive function were associated with worse results on the HADS scale. Chronic Pain Sleep and cognitive function disorders are common in patients with chronic pain and represent factors that have a greater impact than the pain itself on their mental health. Mean and SD of scalesand pain Variables relatedtoHADS scores in chronicpainpatients