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Orthopedic Biomaterials, The World Market
May 1, 2011
Orthopedic biomaterial products, which can be organic or synthetic in nature, are
implanted into or near a bone fracture to facilitate healing or to compensate for a lack or
loss of bone tissue. Biomaterials are expected to be biocompatible and not cause
inflammation or rejection. Biomaterials used in orthopedic surgery include autografts,
allografts, xenografts, ceramics, polymers, bone growth factors and synovial fluid
substitutes. Among the prominent applications for orthopedic biomaterials are surface
coatings for hip prostheses, bone cements, bone defect fillers, and fracture fixation
plates.
This report focuses on orthopedic biomaterials. The specific areas covered in this report
are the products and markets for bone allografts and bone graft substitutes, which
include allograft bone substitutes, ceramic-based, polymer-based, factor-based
(recombinant growth factors) and hyaluronic acid synovial fluid substitutes.
Kalorama's Orthopedic Biomaterials, World Market, one of the few resources available
on this market, includes the following segments:
Allograft Products (including DBM, Machined Bone and Standard Allograft)
Ceramic Products
Polymer Products
rhBMP Products
HA Viscosupplemental Products
As part of Kalorama Information's exhaustive coverage of the orthopedic biomaterials
market for each area, the following data are provided:
Historical Revenues from 2006-2010
Forecasts to 2016
Competitive Market Share
Discussion of Issues and Trends
Review of New Products
Company Profiles
A truly global resource, this report provides information on the following world regions:

2. US
Europe
Asia
Rest of World
The information for this report was gathered using both primary and secondary research
including comprehensive research of secondary sources such as company literature,
databases, investment reports, and medical and business journals. Telephone
interviews and email correspondence were the primary method of gathering information.
For the purpose of this study, Kalorama Information conducted interviews with key
industry officials, consultants, health care providers, orthopedic surgeons, research
institutes, and government personnel. These sources were the primary basis for
information specifically relating to trends in the orthopedic biomaterials industry,
revenue and market share data presented in this report. Specific interviews with
orthopedic implant device and biomaterial company representatives included marketing
directors, division managers, and product representatives.
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3. Orthopedic biomaterial products, which can be organic or synthetic in nature, are
implanted into or near a bone fracture to facilitate healing or to compensate ...
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TABLE OF CONTENTS
CHAPTER ONE: EXECUTIVE SUMMARY
Overview
Scope and Methodology
Musculoskeletal Conditions/Treatments
Prevalence of Musculoskeletal Conditions

4. Most Common Musculoskeletal Conditions
Joint Replacement Procedures
o Gene Therapy and Tissue Engineering
o Genetically Engineered Stem Cells
Biomaterials Products
Global Orthopedic Biomaterials Market
Market Segment Analysis
o Allograft Bone Substitutes
o Ceramic-based Bone Substitutes
o Polymer-based Bone Substitutes
o BMP Products
o HA Viscosupplementation Substitutes
CHAPTER TWO: INTRODUCTION
Bone Characteristics
Types of Bone
o Cortical Bone
o Cancellous Bone
o Bone Cells
o Osteoblasts
o Osteoclasts
o Osteocytes
o
The Functions of Bone
Bone Matrix
Joint Components
Prevalence of Musculoskeletal conditions
Musculoskeletal Conditions In Europe
Musculoskeletal Conditions In the United States
Common Musculoskeletal Conditions
o Arthritis
o Osteoarthritis
o Bone Fractures
o Ligament Injuries
Joint Replacement Procedures
o Introduction
o Knee Reconstruction
o Hip Reconstruction
o Spine Fusion
 Artificial Disc Replacement
o Gene Therapy and Tissue Engineering

5. o Genetically Engineered Stem Cells
CHAPTER THREE: TYPES OF MATERIALS
Overview
Brief History of Orthopedic Biomaterials
Categories of Orthopedic Biomaterials
Bone Grafts
Overview
Types of Bone Grafts
o Autografts
 Advantages
 Disadvantages
o Allograft
o Xenografts
 Advantages
 Disadvantages
Allograft Bone Graft Substitutes
Overview
Demineralized Bone Matrix
Types of DBM Products
Stem Cell-based Allograft
Conventional Allograft
Machined Allograft
Ceramic-based Bone Graft Substitutes
Overview
Types of Materials
o Hydroxyapatite
o Ceramic Coated Joint Implants
o Coralline Hydroxyapatite
o Tricalcium phosphate
o Calcium Phosphate
o Calcium Sulphate
o
Polymer-based Bone Graft Substitutes
Overview
Nondegradable Polymers
Bioabsorbable Polymer Biomaterials
o Polylactic Acid (PLA)
o Polyglycolic Acid (PGA)
o Copolymers

6. Factor- based Bone Graft Substitutes
Overview
Types of Growth Factors
o Bone Morphogenic Protein (BMP)
o Transforming Growth Factor-Beta (TGF-β)
o Fibroblast Growth Factors (FGFs)
o Insulin-Like Growth Factors (IGFs)
o Platelet-Derived Growth Factor (PDGF)
Carriers/Delivery Systems for Growth Factors
o Type-1 Collagen
o Demineralized Bone Matrix (DBM)
o Polymers
o Ceramics
o Hyaluronic Acid
o Gene Therapy
Hyaluronic Acid Synovial Fluid Substitute
Overview
Viscosupplementation
CHAPTER FOUR: ORTHOPEDIC BIOMATERIALS MARKETS
Introduction
Global Market Analysis and Forecast
Orthopedic Biomaterial Market Drivers
Orthopedic Biomaterials Market Forecast
Global Regional Markets
Market Segment Analysis
Market Value and Growth by Segment
Allograft Bone Market Analysis
Allograft Applications
o Spinal Fusion
o Trauma
o Joint Revision
Allograft Products
o DBM
o Machined Bone Products
o Allograft Stem Cell Products
o Trinity Evolution
o Osteocel
o PureGen
o AlloStem
o BioDfactor
Allograft Bone Market
Market Drivers and Limitations
Allograft Bone Competitors’ Market Share

7. Ceramic-based Bone Substitute Market Analysis
Ceramic Applications and Products
o Ceramic-based Implants
o Ceramic-based Bone Substitute Products
Ceramic Biomaterials Market
o Market Drivers and Limitations
o Ceramic Competitors’ Market Share
Polymer-based Bone Substitutes Market Analysis
o PEEK Applications
Bioabsorbable Polymers
o Applications for Polymer Bioabsorbable Biomaterials
Combination Products
Polymer-based Biomaterials Market
Market Drivers
Competitors’ Market Share
Bone Morphogenetic Proteins Market Analysis
Products and Applications
o InFuse and InductOS (RhBMP-2)
o OP-1 (rhBMP-7)
o Carrier Materials for BMPs
BMP World Market
Current Market Status
HA Viscosupplementation Market Analysis
Market Drivers and Trends
HA Viscosupplementation Competitors’ Market Share
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