This document discusses issues surrounding the diagnosis and treatment of illnesses as idiopathic or of unknown origin. It argues that many conditions labeled as idiopathic may actually be iatrogenic, or caused by medical treatment. It notes that a high percentage of medical interventions and clinical practice guidelines are not evidence-based, and many medications' safety and efficacy have not been adequately tested, especially for women and children. As a result, so-called idiopathic conditions may in fact be adverse effects that were never studied or recognized. The document critiques overreliance on medication and lack of research into environmental or lifestyle causes of disease. It calls for more rigorous testing of treatments, especially for vulnerable groups.
Best Rate (Hyderabad) Call Girls Jahanuma ⟟ 8250192130 ⟟ High Class Call Girl...
Deconstructing Modern Illness: Idiopathic or Iatrogenic
1. Lucine Health Sciences, Inc. | Hormones Matter
Deconstructing Modern
Illness
Idiopathic or Iatrogenic?
2. Lucine Health Sciences, Inc. | Hormones Matter
You did then what you
knew how to do,
And when you knew better,
You did better.
Maya Angelou
3. Lucine Health Sciences, Inc. | Hormones Matter
Core Principles
o Pregnancy is an opportunity to break cycles of bad health
o Reproduction should be viewed from a much broader and longer
perspective.
o Dad’s health matters
o At least one year pre-conception – postpartum year
o Transgenerational – can’t undue sins of our parents and grandparents, but
we can protect our children and grandchildren
oEverything is connected – a more holistic and systems approach
to health
o Health is complicated, disease is individual, we have a lot to learn
o If the symptoms don’t fit Dx categories, trust your gut and figure
out what is wrong
5. Lucine Health Sciences, Inc. | Hormones Matter
Who am I?
oMom, wife, jock, researcher, writer, women’s health advocate
oBackground in maternal health and hormones
oMore recently, medication adverse reactions, nutrition and
mitochondrial damage
7. Lucine Health Sciences, Inc. | Hormones Matter
What I Really Do
o150,000+ monthly
views
o1200+ articles and
growing
o150 guest
contributors/writers
• 18 PhDs, 5 MDs, 2
DPTs
oThousands of
comments
Cause trouble.
11. Lucine Health Sciences, Inc. | Hormones Matter
What I Have Learned
oEnvironment matters
• More than genetics
oHealth and disease are both sudden and slow
• Thresholds and tipping points
oAll about the mitochondria
• Mitochondria determine everything
Everything we think we know is wrong.
12. Lucine Health Sciences, Inc. | Hormones Matter
Let the Deconstruction Begin.
Do we know what we think we know?
13. Lucine Health Sciences, Inc. | Hormones Matter
“There is often something sinister about familiar concepts.
The more familiar or ‘natural’ they appear, the less we
wonder what they mean; but because they are widespread
and well-known, we tend to act as if we know what we
mean when we use them.”
Devisch, I. & Murray, S., 2009. doi:10.1111/j.1365-2753.2009.01232.x
Just because it is familiar
Doesn’t make it right or true.
15. Lucine Health Sciences, Inc. | Hormones Matter
Implications of idiopathy
oEverything we don’t understand is idiopathic
• Illness of unknown origin is random – we cannot
know the causes
oWe have no responsibility for randomness
• Choices/behaviors don’t matter
• No need to study
• Can only treat but never cure or prevent
16. Lucine Health Sciences, Inc. | Hormones Matter
Cancer is random?
“These results suggest that only a third of the variation in
cancer risk among tissues is attributable to environmental
factors or inherited predispositions. The majority is due to
‘bad luck,’ that is, random mutations arising during DNA
replication in normal, noncancerous stem cells.”
Tomasetti & Vogelstein 2015. Science, Vol. 347, Issue 6217, pp. 78-81
DOI: 10.1126/science.1260825
18. Lucine Health Sciences, Inc. | Hormones Matter
Randomness means we can
ignore things like this
19. Lucine Health Sciences, Inc. | Hormones Matter
And this…
o Pharmaceutical and
environmental chemicals
rearrange MLL Gene via
topoisomerase inhibition
• Glyphosate (and other
herbicides/pesticides),
fluoroquinolone antibiotics,
hormonal contraceptives,
HRT and other drugs
o Topoisomerases manage
nDNA, mtDNA replication
and repair.
MLL- related leukemias are not heritable, not
found in germlines, but a result of exposure
in utero (infant leukemia) or during later child
development (pediatric leukemia).
20. Lucine Health Sciences, Inc. | Hormones Matter
25-75% of the symptoms reported in
outpatient settings are considered
medically unexplained.
How much of medicine is
idiopathic?
Source: Smith, R.C. and Dwamena, F.C., 2007. Classification and diagnosis of patients with medically unexplained symptoms. Journal of general internal medicine, 22(5),
pp.685-691.
21. Lucine Health Sciences, Inc. | Hormones Matter
Idiopathy exists, not because this stuff is
unknowable, but rather, because we
choose not to look.
Source: Smith, R.C. and Dwamena, F.C., 2007. Classification and diagnosis of patients with medically unexplained symptoms. Journal of general internal medicine, 22(5),
pp.685-691.
22. Lucine Health Sciences, Inc. | Hormones Matter
70% OF OB/GYN CLINCAL
PRACTICE GUIDELINES
NOT BASED ON EVIDENCE
For women…
Idiopathy runs rampant.
23. Lucine Health Sciences, Inc. | Hormones Matter
50%
OF MEDICAL
INTERVENTIONS
UNPROVEN
ONLY 35% KNOWN TO BE BENEFICIAL
Source: BMJ Clinical Evidence, http://clinicalevidence.bmj.com/x/set/static/cms/efficacy-categorisations.html
For medicine in general
We really don’t know what we think we know.
24. Lucine Health Sciences, Inc. | Hormones Matter
Source: BMJ Clinical Evidence, http://clinicalevidence.bmj.com/x/set/static/cms/efficacy-categorisations.html
25. Lucine Health Sciences, Inc. | Hormones Matter
Medication nation
Mayo Clinic Reports
o70% adults take
prescription medications
chronically
o50% take 2 or more meds
o20% take 5 or more meds
“Before the SSRIs, drugs were poisons that came with risks. Now they are fertilizers to be
used as widely as possible, being given in ever larger amounts to children and the elderly -
the only risks the authorities can see it would seem stem from not using enough of them.”
David Healy
26. Lucine Health Sciences, Inc. | Hormones Matter
If only 50% of medications have sufficient
evidence of efficacy, what happens when we
combine multiple medications?
Efficacy?
Safety?
27. Lucine Health Sciences, Inc. | Hormones Matter
Can we really know what illnesses chronic
polypharmacy use might spur if we’ve never
bothered to ask the question?
28. Lucine Health Sciences, Inc. | Hormones Matter
If 25-75% of symptoms can be considered
medically unexplained, how certain are we of
our current diagnostics?
30. Lucine Health Sciences, Inc. | Hormones Matter
The problem of iatrogenesis
o3rd leading cause of death in hospitalized patients
• Estimated at 200,000-400,000 patients annually
• 6.8% of cases were attributable to an adverse drug
reaction 1964-1995
oFDA/ADR data (2011)
• 2.1 to 2.7 million Americans suffer from an serious
adverse drug reaction annually
• 128,000 result in death
James, J.T., 2013. A new, evidence-based estimate of patient harms associated with hospital care. Journal of patient safety, 9(3), pp.122-128; Null, G., Dean, C.,
Feldman, M. and Rasio, D., 2005. Death by medicine. Journal of Orthomolecular Medicine, 20(1), pp.21-34; Makary, M.A. and Daniel, M., 2016. Medical error—the
third leading cause of death in the US. Bmj, 353, p.i2139; Stokowski, L.A., 2016. Who believes that medical error is the third leading cause of hospital deaths.
Medscape, May, 26Light, D.W., Lexchin, J. and Darrow, J.J., 2013. Institutional corruption of pharmaceuticals and the myth of safe and effective drugs; Light, D.W.,
Lexchin, J. and Darrow, J.J., 2013. Institutional corruption of pharmaceuticals and the myth of safe and effective drugs..
Even as currently defined.
31. Lucine Health Sciences, Inc. | Hormones Matter
Implications of iatrogenesis
oPresumes we know the scope of effects for a given
treatment
• If 50% of treatments unproven, do we really know the
scope of effects?
• Even when tested, often only tested in isolation, in men,
with little application to real world uses
oAnything we don’t know is random or idiopathic
oWe have no responsibility for randomness
oNo need to study
33. Lucine Health Sciences, Inc. | Hormones Matter
Deconstructing Women’s
Health
Where idiopathy, iatrogenesis and willful ignorance
intersect.
34. Lucine Health Sciences, Inc. | Hormones Matter
Women use more medications
than men
A review of insurance records for a 1 year period in 2010
showed:
• Women = 5 prescriptions
• Men = 3.7 prescriptions
• 68% of women versus 59% of men had one prescription for at
least one medication for a chronic or acute condition during the
study period.
Women’s Health 2012: The 20th Annual Congress; https://www.washingtonpost.com/blogs/the-checkup/post/women-prescribed-more-drugs-than-men-but-dont-
always-take-them-research-shows/2010/12/20/gIQAJm5hNS_blog.html?utm_term=.f913aa9f54a6
35. Lucine Health Sciences, Inc. | Hormones Matter
During Pregnancy
o80% of women take at least
one medication during
pregnancy
o~30% take 4 or more
medications during
pregnancy
• 60% increase in
medication use during
pregnancy in 30 years
36. Lucine Health Sciences, Inc. | Hormones Matter
Most of these drugs were never
safety tested with women
oNo testing on drugs approved before 1993
oGuidelines not enacted until 1998
37. Lucine Health Sciences, Inc. | Hormones Matter
Even after the regulations
oPer the GAO (2000)
• 52% of clinical trial participants women,
mostly later phases
• Only 22% of early phase trials, where safety
and dosing determined
oPer the IOM OWH (2010)
• Much the same
38. Lucine Health Sciences, Inc. | Hormones Matter
Here’s the thing
Even though women are now allowed in clinical trials, there is
no requirement for researchers/drug companies to determine
whether women react differently than men to a medication
before it is approved.
So they don’t.
39. Lucine Health Sciences, Inc. | Hormones Matter
As a result
oWomen suffer significantly more frequent and
more severe adverse drug events
oFew notice because none of these reactions were
documented in the first place
Cardiovascular disease is the most common cause of death in
American women and in recently recalled medications for heart
disease there were disproportionately higher fatalities and
serious adverse events in women than in men.
– Cochrane Reports
Idiopathic or iatrogenic?
40. Lucine Health Sciences, Inc. | Hormones Matter
Ethical conundrum
oTesting on women might impair reproductive
capacity
oMedication use during pregnancy might
harm the fetus
oBUT women use medications across the
lifespan and during pregnancy
• If we’re not going to test, should we really be
recommending these medications to women?
41. Lucine Health Sciences, Inc. | Hormones Matter
Possible solutions
oAnimal testing
oUse meds only sparingly
in pregnant women
oIntense post market
surveillance
Might temper some of the risks
43. Lucine Health Sciences, Inc. | Hormones Matter
What do human females and
male rodents have in common?
Apparently, they are equivalent.
44. Lucine Health Sciences, Inc. | Hormones Matter
Source: Beery, A., & Zucker, I. (2011). Sex Bias in Neuroscience and Biomedical Research. Neuroscience and Biobehavioral Reviews, 35 (3), 565-572.;
https://genderedinnovations.stanford.edu/case-studies/animals.html
45. Lucine Health Sciences, Inc. | Hormones Matter
No one considered
Until 2014!
that males and females
might be different
46. Lucine Health Sciences, Inc. | Hormones Matter
Perhaps it’s not about ethics at all, but rather,
expediency.
47. Lucine Health Sciences, Inc. | Hormones Matter
Long, inglorious history
• Used from 1957-1961
as anti-emetic,
hyperemesis mostly in
Europe
• 2000-100,000 children
born with severely
malformed limbs
• FDA denied approval
Thalidomide -prescribed for
morning sickness Of medicating women.
48. Lucine Health Sciences, Inc. | Hormones Matter
Diethylstilbestrol (DES) – to prevent miscarriage
At least 3 generations affected: sons, daughters
and grandchildren
Without research
• 5-10 million women from
1940-1970s
• FDA approved, no research
• Late 50s-60s first research:
increased risk of miscarriage
• Multi-generational damage
(cancer, organ malformation,
more)
• Used in farm animals
• Caused cancer in farm hands,
miscarriage and illness in
animals
• Banned in 1958 in animals
• Still used in women for
another 20+ years
51. Lucine Health Sciences, Inc. | Hormones Matter
And for social reasons
1959-1970s physicians and
researchers from the Royal Children’s
Hospital and the University of
Melbourne gave adolescent girls of
tall stature DES to stunt growth.
The rationale behind treating tall girls
was so they could do ballet, buy
clothes more easily, and find
boyfriends and husbands.
Source: Lee & Howell, Tall girls: the social shaping of a medical therapy. Arch Pediatr Adolesc Med. 2006 Oct;160(10):1035-9.
When Being a Tall Girl was a Medical
Condition: DES and the Tall Girls
52. Lucine Health Sciences, Inc. | Hormones Matter
And then covering it up
Used as a pregnancy test 1960s-70s
Equivalent to 13 morning after pills or 157
oral contraceptive pills
January 1975, Dr William Inman,
principal medical officer for the British
Government, had found that women
who took a hormone pregnancy test
“had a five-to-one risk of giving birth to
a child with malformations”.
Dr Inman wrote to Primodos’s German
manufacturer, Schering, so the firm could
“take measures to avoid medico-legal
problems”, rather than recall the drug.
A later document explains that Dr Inman
destroyed the materials on which his
findings were based, “to prevent
individual claims being based on his
material”.
Source: http://www.telegraph.co.uk/news/2017/03/18/new-evidence-claims-against-pregnancy-test-drugs-linked-
birth/
53. Lucine Health Sciences, Inc. | Hormones Matter
It’s worse for pregnant women
• There are no data for [insert vaccine]
administered to pregnant women to inform
vaccine-associated Package insert
• Available data on [insert vaccine] administered
to pregnant women are insufficient to inform
vaccine-associated risks in pregnancy.
• There were no developmental toxicity studies
of [insert vaccine] performed in animals.
• It is not known whether [insert vaccine] is
excreted in human milk.
• Data are not available to assess the effects of
on the breastfed infant or on milk
production/excretion.
Despite all marketing
to the contrary, most
medications and
vaccines were never
tested for use during
pregnancy.
Source: Package inserts
54. Lucine Health Sciences, Inc. | Hormones Matter
We never learned
With little evidence of safety and
efficacy
We continue to drug women
55. Lucine Health Sciences, Inc. | Hormones Matter
And for children
o Only 10-20% of
medications for
pediatric use have been
tested in children
o Pharmacokinetic and
pharmacodynamic
research developed in
adult males
o Rampant off-label for
kids, particularly kids in
foster care
Sources: Conroy, S., McIntyre, J., Choonara, I., & Stephenson, T. (2000). Drug trials in children: problems and the way forward. British Journal of Clinical Pharmacology, 49(2),
93–97. http://doi.org/10.1046/j.1365-2125.2000.00125.x ; FDA, https://www.fda.gov/Drugs/ResourcesForYou/Consumers/ucm143565.htm;
http://pharmaceuticalcommerce.com/brand-marketing-communications/pediatric-drug-market-finds-its-own-pathway/
“In the absence of rigorous pediatric clinical
trial data, physicians are forced to act as if
children are just ‘small adults’ with a smaller
weight, and then interpret the adult data to
adjust the dose. But statistically, we know that
approach only works in 6% of the cases.”
57. Lucine Health Sciences, Inc. | Hormones Matter
We’re addicted
Psychotropics prescribed in
the US
o 274,000 infants (0-1 year olds)
o 370,000 toddlers (1-3 year olds)
“Prescriptions of powerful
antipsychotics such as Risperdal for
infants and very young children have
also sharply risen. Office visits for
childhood bipolar disorder have risen
40-fold over the past decade in the
U.S.” To solving problems with pills
and looking away when
problems arise.
58. Lucine Health Sciences, Inc. | Hormones Matter
If drugs are not tested in women or children and thus, their
effects in women are unknown, they can easily be disregarded
and labeled as idiopathic.
If they are idiopathic, rather than iatrogenic, there is no need
to investigate or even acknowledge side effects as real.
For all intents and purposes, they simply do not exist.
59. Lucine Health Sciences, Inc. | Hormones Matter
For example
oLupron – GnRHa
• Chemically castrates
oDeveloped for male prostate cancer
• Tested on 6 healthy men
• One low dose for a drug to be used repeatedly and chronically at
higher doses
oApproved for
• Women with endometriosis, fibroids, heavy bleeding
• IVF
• Children with precocious puberty, gender dysphoria
60. Lucine Health Sciences, Inc. | Hormones Matter
Considered perfectly safe by
many practitioners
• No recognition chemical
castration might cause problems
• Depletes gonadal hormones
• Hormones have receptors
everywhere and are involved with
a myriad of functions beyond
reproduction
• With very little research pre – or
post-market, symptoms are
considered idiopathic or
hysteric.
61. Lucine Health Sciences, Inc. | Hormones Matter
It’s not safe
Lupron damages the mitochondria, perhaps irrevocably.
66. Lucine Health Sciences, Inc. | Hormones Matter
Environmental toxic soup
“Unlike the current system in Europe,
the 60,000-plus chemicals in
production when the US’s TSCA took
effect 39 years ago continued to be
used without any safety reviews. Most
are still in use today, although some
have since filed toxicity data.
The US allows the use of many
chemicals that are banned elsewhere,
and its primary chemicals law has
failed to keep up with thousands of
chemicals currently in use, including
the approximately 2,000 new chemicals
introduced each year.”
Source: https://www.theguardian.com/lifeandstyle/2015/feb/13/us-senate-toxic-chemicals-law-health-safety
Friday 13 February 2015 13.41 EST
67. Lucine Health Sciences, Inc. | Hormones Matter
That remain in our bodies
Certain polychlorinated biphenyls, organochlorine pesticides, PFCs,
phenols, PBDEs, phthalates, polycyclic aromatic hydrocarbons, and
perchlorate were detected in 99–100% of pregnant women. The median
number of detected chemicals by chemical class ranged from 4 of 12 PFCs
to 9 of 13 phthalates. Across chemical classes, median number ranged
from 8 of 17 chemical analytes to 50 of 71 chemical analytes.
BPA and tOP were detected in 92.6% and 57.4% of the persons, respectively...Females
had statistically higher BPA LSGM concentrations than males (p = 0.043). Children had
higher concentrations than adolescents (p < 0.001), who in turn had higher
concentrations than adults (p = 0.003).
69. Lucine Health Sciences, Inc. | Hormones Matter
What would normally filter the
damage
Medicines
Toxins
Bad diet
Nutrients
Exercise
Has been compromised.
70. Lucine Health Sciences, Inc. | Hormones Matter
Maternal nutrient deficiency is
rampant
Oxidative stress caused by free radicals has been implicated in many studies of the etiology
of preeclampsia (38). Because ascorbic acid and vitamin E inhibit free radical formation, a
double-blind randomized trial was conducted in 283 women who had either a previous
history of pregnancy complications or an abnormal ultrasound (39). The supplement
provided 1000 mg ascorbic acid and 400 IU vitamin E daily from week 16–22 of
pregnancy, and resulted in a 76% reduction in preeclampsia, and a 21% reduction in
indicators of endothelial activation and placental dysfunction.
Evidence from experimental animals supports the concept that in addition to primary deficiencies,
secondary embryonic and fetal nutritional deficiencies can be caused by diverse factors including
genetics, maternal disease, toxicant insults and physiological stressors that can trigger a maternal
acute phase response. These secondary responses may be significant contributors to the occurrence
of birth defects. An implication of the above is that the frequency and severity of pregnancy
complications may be reduced through an improvement in the micronutrient status of the mother.
Micronutrient status in fetal and early life may alter metabolism,
vasculature, and organ growth and function, leading to increased risk
of cardiometabolic disorders, adiposity, altered kidney function, and,
ultimately, to type 2 diabetes and cardiovascular diseases.
71. Lucine Health Sciences, Inc. | Hormones Matter
The food we eat
Isn’t really food
High calorie malnutrition
73. Lucine Health Sciences, Inc. | Hormones Matter
We’re told it’s real food
“Everything nature can do, man can do
so much better and more profitably.”
o ‘Natural’ cheese that matures in 72
hours.
o Preservatives prevent produce
browning
And if we can’t, then re-define
o ‘Clean labeling’ removes the most
glaring industrial ingredients and
replaces them with substitutes that
sound natural and benign.
“For the salesman, this preparation was
a technical triumph, a boon to caterers
who would otherwise waste unsold
food. There was a further benefit:
NatureSeal is classed as a processing
aid, not an ingredient, so there’s no
need to declare it on the label, no
obligation to tell consumers that their
“fresh” fruit salad is weeks old.”
But it isn’t.
74. Lucine Health Sciences, Inc. | Hormones Matter
Industrial food production
o Highly processed food-like products
o Sugar, carbs, fats and chemicals
o Genetically culled produce
o 70% reduced nutrient content
o With no genetic variation ( 96%)
o Glyphosate, toxic adjuvants and more
o Chemically laden meats
o Heavy antibiotics, antibiotic resistant bacteria,
growth and other hormones
Has stripped our food of critical nutrients
75. Lucine Health Sciences, Inc. | Hormones Matter
It’s an industrial descaling agent
oUsed to remove minerals from pipes
oDoes the same in our bodies
• Blocks critical enzymes and amino acids
• Disrupts vitamin A metabolism
• Weakens the blood brain barrier
oCarcinogenic, mutagenic, teratogenic
and an endocrine disruptor
• Topoisomerase inhibitor
• Glycine analog
• Mineral chelator
oWould kill all the plants if not
genetically altered to withstand the
toxinAnd a powerful antibiotic.
76. Lucine Health Sciences, Inc. | Hormones Matter
A perfect storm
Of pharmaceutical and environmental toxicants.
77. Lucine Health Sciences, Inc. | Hormones Matter
But, cancer is random?
And most women’s symptoms are psychosomatic – until they aren’t’.
84. Lucine Health Sciences, Inc. | Hormones Matter
Increase in childhood illness
o1-68 children develop
autism
o Neurodevelopmental and behavioral
problems on the rise
o1 in 13 children food
allergies
o1 in 1000 – 10,000 children
with autoimmune disorder
(celiac, JA, TD1)
JAMA Pediatr. 2013;167(2):141-148; Psychiatry (Edgmont). Aug 2005; 2(8): 14–19; Arch Gen Psychiatry. 2012;69(12):1247-1256; BMC
Pediatrics 2013, 13:40 3; JAMA. 2014;311(17):1778-1786.
Idiopathic or random?
85. Lucine Health Sciences, Inc. | Hormones Matter
Something is not working
• Spend more healthcare
• Highly vaccinated
• Taking lots of meds
• That were never tested
on over half the
population
• Of those, only 50%
considered effective
• Embrace
environmental/industrial
chemistry
• Living sicker
• With increasingly
complicated but
‘random’ diseases
• Dying younger
87. Lucine Health Sciences, Inc. | Hormones Matter
How can we reasonably assert
Which health issues are idiopathic and which are caused by us?
88. Lucine Health Sciences, Inc. | Hormones Matter
Except in rare cases
oMost modern illness is iatrogenic – caused by us
• Our choices individually and collectively
• Diet, lifestyle, pharmaceutical and environmental decisions
“I believe the collective denial of lifestyle disease is the reason cardiology is in
an innovation rut. This denial is not active or overt. It is indolent and
apathetic… This is how I see modern cardiology. Our tricks can no longer
overcome eating too much and moving too little. We approach health but
never get there. If you waddle, snore at night, and cannot see your toes while
standing, how much will a statin or ACE inhibitor or even LCZ696 help?”
Mandrola, J., 2015. Heart Disease and Lifestyle: Why Are Doctors in Denial? Medscape. http://www.medscape.com/viewarticle/837975
A hard truth that none of us wants to admit
89. Lucine Health Sciences, Inc. | Hormones Matter
Now what?
Who cares whether we call it idiopathic or iatrogenic,
how do we fix this mess?
90. Lucine Health Sciences, Inc. | Hormones Matter
Easy answer
oStop
• eating food-like products
• looking for medical
solutions to what are
lifestyle issues
oGo back to basics
• What does your body
need and is it getting it?
91. Lucine Health Sciences, Inc. | Hormones Matter
More complicated answer
oFind the root causes of illness and
fix them
• Stop treating symptoms
• Learn the chemistry
oBecome an expert in your/your
family’s health
• Own your health
oShare what you learn with others
• Build the knowledge base
• Publish/post online if you can
Entire model has to change.
92. Lucine Health Sciences, Inc. | Hormones Matter
What I have learned
It’s all about the
mitochondria.
Feed them well and life will be good.
93. Lucine Health Sciences, Inc. | Hormones Matter
Mitochondria
o1000-2000 per cell
oFuel source for cells
• Convert food to ATP
oSit at center of cell survival
• Sense and respond to all threats
oMasters at adapting to toxic environments – until
they aren’t
• Seemingly endless repertoire of survival cascades
• Threshold and tipping points
94. Lucine Health Sciences, Inc. | Hormones Matter
But that’s not all they do
o Mitochondria control just about everything
o Energy
o Steroidogenesis
o Inflammatory and immune
activation/deactivation
o Ca2+ homeostasis (cell excitotoxicity)
o Apoptosis/necrosis
Damage at your own risk.
95. Lucine Health Sciences, Inc. | Hormones Matter
All they ask of us is to feed them
well
oTo get from food to
ATP
• O2 (mitochondria
need to breathe)
• Lots of nutrients
• >24 vitamins and
minerals
And not hurl too many poisons at them.
Source: https://www.invitehealth.com/ARTICLE-nutrition-and-fibromyalgia.html
96. Lucine Health Sciences, Inc. | Hormones Matter
Western diet = high calorie
malnutrition.
We don’t.
Nutrient deficiency alone will damage mitochondria,
evoke chronic and complicated illness and can lead to
death.
97. Lucine Health Sciences, Inc. | Hormones Matter
All pharmaceutical, environmental, and
industrial chemicals damage the
mitochondria and deplete nutrients.
But wait, there’s more…
98. Lucine Health Sciences, Inc. | Hormones Matter
Mitochondria are targets
Sensors of cell danger
99. Lucine Health Sciences, Inc. | Hormones Matter
Poor nutrition, high toxic load
Foundation from
which most parents-
to-be approach
reproduction
With the cascade of ill-
health already in progress.
100. Lucine Health Sciences, Inc. | Hormones Matter
Net result
“These are partial defects.
Mitochondrial dysfunction doesn’t
really cause anything, what it does is
predisposes towards seemingly
everything. It’s one of many risk factors
in multifactorial disease. It can
predispose towards epilepsy, chronic
fatigue, and even autism, but it doesn’t
do it alone. It does it in combination
with other factors, which is why in a
family with a single mutation going
through the family, everyone in the
family is affected in a different way.
Because it predisposes for disease
throughout the entire system.”
Dr. Richard Boles, Geneticist
Complicated disease processes that affect
everything and don’t fit our neat little
diagnostic categories.
101. Lucine Health Sciences, Inc. | Hormones Matter
How prevalent is mitochondrial
disease or dysfunction?
“Disorders of the mitochondrial respiratory chain affect at least 1 in 8000 of the population,
making them among the most common genetically determined diseases.”
Patrick Chinnery, Medical School, Newcastle upon Tyne.
Prevalence is likely underestimated because
functional mitochondrial damage is often
overlooked and most mitochondrial
deficits, especially those emerging later in
life, remain undiagnosed.
Not widely recognized
1 in 500
102. Lucine Health Sciences, Inc. | Hormones Matter
Energy is key
• Insufficient mitochondrial ATP
• Cells adapt alternative, less efficient
energy pathways
o Cancer pathways or they die
• Mitochondria activate danger
protocols and deactivate extraneous
tasks
• Cells die, tissues die, organs die,
and we die (sometimes slowly and
painfully, sometimes quickly)
103. Lucine Health Sciences, Inc. | Hormones Matter
How important are nutrients
oCells cannot ‘breathe’ without certain
vitamins and minerals
• Thiamine and magnesium
oNutrient deficiency causes cellular hypoxia
• No obstruction necessary
oBrain and heart most adversely effected
107. Lucine Health Sciences, Inc. | Hormones Matter
Not just about mom
o mDNA passed from mom-child,
o But mitochondria rely on
nuclear DNA to function (~90%)
o If Dad is unhealthy and
nutrient deficient,
dysfunctional mitochondria
are possible in the offspring,
even if mom is healthy
Dad’s health matters too!
108. Lucine Health Sciences, Inc. | Hormones Matter
Long before conception
o The lifetime of unhealthy habits affect your
mitochondria
o Mitochondria have memories
o Cleaning up a few months before conception is
good but not good enough
o Should consider health of both parents at least a
year before conception
Health has to be considered
109. Lucine Health Sciences, Inc. | Hormones Matter
Nutrients minimize damage
Medicines
Toxins
Diet
Nutrients
Exercise
Nutrient deficiency maximizes damage.
111. Lucine Health Sciences, Inc. | Hormones Matter
Avoid the toxins
Clean up the diet
Feed the deficiencies
112. Lucine Health Sciences, Inc. | Hormones Matter
Idiopathy versus iatrogenesis
oWhen presented with complicated case, a disease
process that doesn’t seem to fit into any one category
• Remove the notion of randomness/idiopathy
• Return the notion of responsibility
• Figure it out (together)
• Think mitochondria
oAsk
• What the patient needs to be healthy
• Are they getting it
oFix it
113. Lucine Health Sciences, Inc. | Hormones Matter
Websites
o LucineHealthSciences.com I Business
o HormonesMatter.com I online journal, medication adverse events
surveys
Social Media
o Facebook pages: Hormones Matter, Lucine Women Community
o Twitter: @chanatlucine, @hormonesmatter
o Email: chandler@lucinehealthsciences.com or
chandler@hormonesmatter.com
How to find me
Editor's Notes
Leukemia in infants less than one year old is a rare, 41 cases per one million births annually in the US; but it is often deadly. Only 42% of infant leukemia patients survive beyond five years of age making it one of the more devastating forms of cancer. A large percentage (75%) of the babies with infant leukemia carry a specific mutation on the MLL gene at chromosome 11q23. The MLL gene is responsible for hematopoiesis or blood cell development. An error in blood cell development is at the root of this disease process, and unfortunately, it appears to be environmentally induced by specific, and increasingly common, in utero chemical exposures.