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Cisapride and Ventricular Arrhythmia 3.11.08

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Leonard Davis Institute of Health Economics
Leonard Davis Institute of Health Economics

Author: Sean Hennessy

Health & Medicine
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[object Object],[object Object],[object Object],[object Object],Cisapride and Ventricular Arrhythmia Sean Hennessy, PharmD, PhD 1 , Charles E. Leonard, PharmD 1 , Craig Newcomb MS 1 , Stephen E. Kimmel, MD, MSCE 1,2 , Warren B. Bilker, PhD 1 1 Center for Clinical Epidemiology & Biostatistics, Department of Biostatistics & Epidemiology, and Center for Education & Research on Therapeutics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States 2 Division of Cardiology, Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States Funding Sources: NIH (RO1 HL076697) & AHRQ (U18 HS010399) ,[object Object],* adjusted for age, sex, race, state, nursing home status, and potential confounders changing the OR by ≥10 %† ,[object Object],^ adjusted for age, sex, race, state, and nursing home status HIGH vs. LOW DOSE CYP450 INHIBITION ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Methods ,[object Object],[object Object],[object Object],Conclusions ,[object Object],Results 1.00 (reference) 0.86 (0.67 to 1.08) 72 83,576 195,199 PPI 1.21 (0.79 to 1.80) 1.04 (0.73 to 1.43) 38 36,602 195,199 metoclop 1.49 (0.96 to 2.25) 1.28 (0.89 to 1.78) 35 27,385 98,961 cisapride Unadjusted rate ratio (95% CI) IR per 1,000 p-y (95% CI) Events Person-years (p-y) Users Drug 15.16 (8.15-28.19) current class III antiarrhythmic use † 2.65 (1.73-4.07) past digoxin use † 2.62 (1.79-3.84) past kidney disease dx † 3.17 (2.04-4.93) past heart failure/cardiomyopathy dx † 1.39 (0.92-2.10) past coronary artery disease dx † 0.62 (0.43-0.90) female sex Fully adjusted* OR (95% CI) Selected model variables of interest ,[object Object],[object Object],Background ,[object Object],Aims

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