Demencia 2010

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E. Avalos

Actualización 2010 en Demencia - Asociación Guatemalteca de Neurología Virtual

Health & Medicine

Dr. Edgar Avalos Herrera Neurólogo Internista

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Después del cáncer, las enfermedades cardiovasculares y los trastornos cerebrovasculares, la demencia es el cuarto problema de salud de países desarrollados. Estas enfermedades crónicas son la causa de aproximadamente 60% de las muertes y 80% de estas ocurren en países de bajos y medianos ingresos. Por lo anterior, es importante conocer cuales son los diferentes tipos de demencia que existen, cuales son sus síntomas, y así poder tener un diagnóstico temprano y establecer medidas terapéuticas adecuadas para cada paciente.

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Running head: CHRONIC ILLNESS 1 CHRONIC ILLNESS 8 Treatment of Dementias, Including Alzheimer’s Disease Estrella Gonzalez South University SU-NSG4055-WK1-A3 Treatment of Dementias, Including Alzheimer’s disease About Dementia and Alzheimer’s disease Dementia is characterized by the declining of cognitive functioning. The thinking, memory, and reasoning capabilities of a person with dementia is influenced to a point that interferes with their ability to do their daily activities (Alzheimer’s Association, 2016). The dementia itself is not an illness it is the most prevailing symptom of Alzheimer’s. Alzheimer’s disease is the cause of between 60% and 80% of all dementia cases (Alzheimer’s Association, 2016). There are various other factors that can lead to a demented state such as severe mental illness such as depression, delirium, dehydration, chronic alcoholism, some brain tumors and illnesses, or even Vitamin B12 deficiency (Ridley, Draper & Withall, 2013; Rossor et al., 2010). The reason for selecting dementias and Alzheimer’s disease is because these are associated with much other comorbidity which can easily affect a patient when not properly taken care of. Individuals with dementia are three times more prone to be hospitalized for preventable reasons. The loss of cognitive functioning makes the patients of dementia and Alzheimer’s to be dependent on others to do even the simplest of daily tasks. This makes coping with these conditions hard not only for the patients but also for their caregivers, family, support groups, and peers. Therefore, it is important to develop a good care plan for such patients to cater for their psychosocial needs as well as their biomedical needs. Morbidity and Comorbidity of Dementia and Alzheimer’s disease Other form of dementia and Alzheimer’s are leading cause of disability in America. In 2014 Alzheimer was one of the principles causes of mortality in the United States. Based on the death certificate data, Alzheimer’s is the 6th leading cause of mortality for adults aged 18 and older (HealthyPeople2020, nd). This illness is mainly common among the elderly population aged 65 and older. As of 2016, the prevalence of this disease in this population group was 11%, which are approximately 5.2 million people. Around 4% of all deaths in 2014 were Alzheimer’s related (HealthyPeople2020, nd). The percentage of Alzheimer’s disease-related deaths has increased significantly, partly because of the increased elderly population. The death rate due to Alzheimer’s has increased by 55% since 1999 (HealthyPeople2020, nd). Alzheimer’s and other forms of dementia are commonly associated with other physical and psychiatric comorbidities. Some of the common psychiatric comorbidities associated with dementia and Alzheimer’s include depression, bipolar disorder, and schizophrenia (Garcez et al., 2015). They have also been associated with other non-psychiatric illn.

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Running head: ALZHEIMER’S DISEASE RESEARCH FINAL 1 ALZHEIMER’S DISEASE RESEARCH FINAL 22 Alzheimer’s Disease Research Final Dalia Catalan Florida National University Alzheimer’s Disease Research Final Phase one Introduction Alzheimer's disease tends to be a progressive, irreversible ailment that impacts the normal functioning of the brain slowly destroying the thinking and memory-related skills and as it progresses it limits the patient the ability to conduct simple tasks ("What Is Alzheimer's Disease?," 2020). Researchers suggest that approximately 6 million American citizens older than 65 years of age have dementia which is caused by Alzheimer's disease. In most patients, the symptoms of this condition begin to be identified when they are in their mid- the 60s. This condition is often ranked as one of the top ten causes of death in the United States, but following a recent investigation, the condition has climbed the ladder and it is currently ranked as the top five leading cause of death in the United States. Often the disease is categorized with cancer and heart disease as the main cause of death among the older population. This paper will focus on planning research that is focused on understanding Alzheimer's disease, its causes symptoms and its impact on the older population. Problem identification Alzheimer's disease tends to be the most common cause of dementia among the older population around the world. The condition impacts the normal functioning of the brain hence causing the loss of cognitive functioning such as reasoning, remembering and thinking. Also, it impacts behavioral abilities to the extent of the victim not being able to conduct various daily essential activities ("What Is Alzheimer's Disease?," 2020). The severity of the brain damage from the mildest stage where the normal function of a person is impact and it progresses to a most severe stage and the victim must be dependent on the people around him or her for basic activities related to daily living. The condition is most popular among the older population and its estimated that the condition has impacted about 6 million senior American citizens' normal function and also it is a leading cause of death among this population ("Alzheimer's Disease Fact Sheet," 2020). Significance of the Problem to Nursing With a significant population estimated to be victims of Alzheimer's disease in the United States, it is most likely that individuals in the nursing practice will encounter patients suffering from this condition either in their personal lives on in their careers. Thus, it is essential for the nurses to be able to understand and recognize the Alzheimer's Disease symptoms, treatment approaches, and options as well as learn how to effectively interact with this vulnerable population ("Update on Alzheimer’s: What Nurses Should Know," 2020). To be able to provide quality health care services the nurse practitioner needs to underst ...

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The biomedical focus on dementia brought the phenomena of what was considered a normal part of ageing into the medical and scientific field of interest (Bartlett, R and O’Connor, D. 2010). This perspective comes with a strong focus on neurodegenerative decline and deficits. Even though Alzheimer’s disease was around for more than 70 years since noted by Alois Alzheimer, it was only in the 1980’s that the “disease emerged as an illness category and policy issue” (Lyman, A. 1989). The Nun Study of David A. Snowdon, PhD, which started in 1991, brought a new perspective to the research into dementia. It was discovered during autopsies that people who have lived their lives without any signs of dementia, actually had amyloid plaques and tangles in their brains congruent to people living with dementia (Snowdon, D.A. 2003). Biomedical research is at this stage the primary focus of research into dementia, receiving most of the funding budget. According to an article in Therapy Today (July 2012) in the UK alone, £66 million will be allocated to dementia research by 2015, of which only £13 million is earmarked for social science research. In the WHO report on Dementia, Daviglus M.L. et al of the US National Institutes of Health state that “firm conclusions cannot be drawn about the association of any modifiable risk factor with cognitive decline of Alzheimer disease”. The importance of the research findings of the biomedical model cannot be underestimated. However, considering the facts that t this point there seems to be nothing that can prevent nor cure Dementia, I am of the opinion that more research and funding should focused on creating a life worth living for people who live with dementia.

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Abin Abraham Mammen, Sharath Hullumani V, Jakka Rahul. Dementia can be broadly defined as depletion in cognitive performance which makes a person unable to meet multiple intellectual demands of daily life. Dementia is acquired, persistent impairment not by delirium in multiple areas of intellectual function. Some dementia types are progressive but others may be persistent or plateau. Sometimes in cases, the onset can be insidious, as is generally the case in AD, but in many cases, whether something develops after head trauma or stroke, the onset of dementia may be acute, particular. While most dementias are the result of changes in the brain structure, infections and metabolic causes can be treated with success. We are confronted with a diagnostic criterion as we delve into the area of dementia and the increasingly expanding area of dementia research.

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Dr. Faiza delivers an insightful lecture on the distinguishing characteristics of skeletal, smooth, and cardiac muscles, offering a comprehensive understanding of their histology, physiological anatomy, electrophysiological properties, and contractile mechanisms. Through meticulous tabulation and comparison, she aims to equip learners with a detailed comprehension of the unique features and functionalities of each muscle type. Beginning with a detailed exploration of histological differences, Dr. Faiza outlines key distinctions such as multinucleation in skeletal muscle, mononucleation in smooth and cardiac muscles, and the presence of striations in skeletal and cardiac muscles. She meticulously elucidates the structural arrangement of each muscle type, highlighting their cellular morphology and organization within tissues. Transitioning to physiological anatomy, Dr. Faiza navigates through various aspects including innervation, level of control, initiation of contraction, and modification by hormones. By delineating the role of the somatic nervous system in skeletal muscle control, and contrasting it with the autonomic nervous system's influence on smooth and cardiac muscles, she offers a nuanced understanding of neural regulation in muscle physiology. Furthermore, Dr. Faiza delves into electrophysiological properties, elucidating the mechanisms underlying action potential generation, duration, and ionic basis in each muscle type. Through insightful analysis, she reveals how differences in action potential characteristics contribute to variations in muscle contraction speed, duration, and resistance to fatigue. Finally, Dr. Faiza meticulously examines the contractile mechanisms of skeletal, smooth, and cardiac muscles, shedding light on the sliding filament theory, mechanisms of calcium action, and speed of contraction. By comprehensively comparing these mechanisms, she provides learners with a deep understanding of the intricate processes governing muscle contraction and function. Through engaging presentation and meticulous analysis, Dr. Faiza's lecture serves as a valuable resource for students seeking a thorough understanding of the fundamental differences between skeletal, smooth, and cardiac muscles.

Difference Between Skeletal Smooth and Cardiac Muscles

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These are simplified slides discussing the regulation of cardiac output and venous return. Learning objectives: 1. Comprehend the determinants of cardiac output and factors affecting cardiac output 2. Comprehend the factors affecting stroke volume and heart rate and total peripheral resistance 3. Identify the factors regulating venous return 4. Discuss the causes of high and low output cardiac failure 5. Enlist the functions of veins and recognise the significance of venous reservoirs Study Resources: 1. Chapter 20, Guyton and Hall Textbook of Medical Physiology, 14th edition 2. Chapter 30 and 32, Ganong’s Review of Medical Physiology, 26th edition 3. Chapter 10, Human Physiology by Lauralee Sherwood, 9th edition 4. Physiology, Cardiac Output - StatPearls https://www.ncbi.nlm.nih.gov/books/NBK470455/

Cardiac Output, Venous Return, and Their Regulation

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