"Human Biowires for Predictive Cardiac Physiology" was presented as a Big Idea Session at the American Heart Association NYC Health Sciences Innovation Investment Forum on April 22, 2015 at Apella, Event Space at Alexandria Center. The presentation focuses on a technological discovery that addresses the lack of physiologically relevant cardiac tissue models for discovery and toxicology testing. Presentation by Milica Radisic, PhD, P.Eng., Functional Cardiovascular Tissue Engineering, TARA Biosystems

1. Milica Radisic, Ph.D., P.Eng.
Institute of Biomaterials and Biomedical Engineering
Department of Chemical Engineering and Applied Chemistry
Heart & Stroke/Richard Lewar Centre of Excellence
University of Toronto
Toronto General Hospital Research Institute
m.radisic@utoronto.ca
Collaborators:
Gordana Vunjak-Novakovic (Columbia)
Gordon Keller (McEwan Centre)
Kumar Nanthakumar (Toronto General Hospital)
Ren-Ke Li (TGH)
Axel Guenther (Toronto)
Robert Langer (MIT)
Peter Backx (Toronto)
Trainees:
Hannah Song
Anne Hsieh
Nimalan Thavandiran
Lewis Reis
Carol Laschinger
Nicole Feric
Yun Xiao
Boyang Zhang
Iran Rashedi
Miles Montgomery
Yimu Zhao
Aric Phanke
Genna Conant
Locke Davenport-Huyer
Anastasia Korolj
Stasja Drecun
Erika Knee
Kujaany Kana
Lana Du
Human Biowires for Predictive
Cardiac Physiology

2. AND
OTHERS….
Withdrawn from the market due to cardiac side effects….
2

3. Human cardiomyocytes cannot be
harvested and used for drug testing
Yang et al Nature 2008
Stem-cell derived CM CM from healthy human adult heart
Ohler et al Cardiol Res Pract 2009
AnimalsCell lines Humans

4. Image from https://shakercups.wordpress.com/

5. Ronaldson et al unpublished
Force Mapping
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6. Yimu Zhao et al unpublished
Nunes et al Nature Methods 2013
Human BioWires Mature Cells
Structure Function
Predictive drug tests- hERG channel blocker E-4031
Time (s)
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7. • Human
• 3D
• Predictive
• Inert and silicone-free
• Open access for liquid dispensing
http://tarabiosystems.com/
Contact: Misti Ushio, mist@hhvc.com