Anatomical Engineering for the Intelligent Design of Medical Devices

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A discussion of the process of anatomical engineering and its several applications in medical device design, from producing patient matched implants to minimally invasive cardiac devices.

Anatomical engineering consists of extracting 3D information from medical imaging data, such as CT or MRI scans and modeling such data using reverse engineering, CAD and additive fabrication techniques.

Some of the discussed applications include the following: the design and fabrication of custom cranial plates, the evaluation of minimally invasive mitral valve surgical devices, the digital design of a spina bifida simulation model for pediatric neurosurgery training, and CAD and stereolithography models of airways for test respiratory gas exchange.

These slides were originally presented by Crispin B. Weinberg at the 2013 Canadian Manufacturing Technology Show as part of the Medical Manufacturing Innovations Conference on October 2nd, 2013.

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  • Anatomical Engineering for the Intelligent Design of Medical Devices

    1. 1. Anatomical Engineering for Intelligent Design of Medical Devices Crispin B. Weinberg, Ph.D. | President Danice Y. Chou, B.S.| Biomedical Engineer Biomedical Modeling, Inc. | www.biomodel.com Biomedical Modeling, Inc. ♦ 2013 1 of 33
    2. 2. Biomedical Modeling, Inc. Inovation Series ♦ Canadian Manufacturing Technology Show: Medical Manufacturing Anatomical Engineering for Intelligent Design of Medical Devices About Biomedical Modeling, Inc. What is Anatomical Engineering? Process Overview Examples Why Anatomical Engineering? Biomedical Modeling, Inc. 2013 Biomedical Modeling, Inc. ♦ ♦ 2013 2 of 33
    3. 3. About Us Biomedical Modeling, Inc. Patient-specific models & design services for dental, medical, engineering, and research applications. We are a Boston-based biomedical engineering company that makes patient-specific anatomical models from medical imaging data (CT, MRI). Biomedical Modeling, Inc. ♦ 2013 3 of 33
    4. 4. Anatomical Engineering What is Anatomical Engineering? Anatomical engineering consists of extracting 3D information from medical imaging data (e.g. CT, MRI) and modeling such data using reverse engineering, CAD, & additive fabrication techniques. Biomedical Modeling, Inc. ♦ 2013 4 of 33
    5. 5. Process Overview The Process Problem Definition Data Acquisition Data Segmentation 3D Modeling (mesh) (For more details, see our Biomodeling Process presentation.) Biomedical Modeling, Inc. ♦ 2013 5 of 33
    6. 6. Examples Anatomical Engineering Examples Device Design & Evaluation Simulation Models Surgical Guides Personal Prosthetics Custom Implants Bioprinted Tissues & Organs Biomedical Modeling, Inc. ♦ 2013 6 of 33
    7. 7. Device Design & Evaluation Biomedical Modeling, Inc. Minimally Invasive Cardiovascular Devices Biomedical Modeling, Inc. ♦ 2013 7 of 33
    8. 8. Device Design & Evaluation Univ. of CA ♦ Univ. of TX ♦ Carnegie Mellon Univ. CFD of LVAD Blood Flow Left: Jarvik Heart, Inc. http://www.jarvikheart.com/basic.asp?id=21 ; Right: Y. Bazilevs, et. al., “Patient-specific isogeometric fluid-structure interaction analysis of thoracic aortic blood flow due to implantation of Jarvik 2000 Left Ventricular Assist Device,” Computer Methods in Applied Mechanics and Engineering, vol. 198, issue 45-46, 2009. http://www.sciencedirect.com/science/article/pii/S0045782509001674 Biomedical Modeling, Inc. ♦ 2013 8 of 33
    9. 9. Simulation Models Biomedical Modeling, Inc. | Materialise Airways & Gas Exchange Left: Biomedical Modeling, Inc. www.biomodel.com ; Right: Materialise and P.J. Antunes, University of Minho, Portugal. http://biomedical.materialise.com/engineering-services-engineering-anatomy Biomedical Modeling, Inc. ♦ 2013 9 of 33
    10. 10. Simulation Models University of Minnesota Interactive Slice World-In-Miniature Coffey et.al., “Interactive Slice WIM: Navigating & Interrogating Volume Data Sets Using a Multi-surface, Multitouch VR Interface”, IEEE Trans. Visualization and Computer Graphics, vol. 8, no. 10, Oct. 2013. http://www.computer.org/csdl/trans/tg/2012/10/ttg2012101614-abs.html Biomedical Modeling, Inc. ♦ 2013 10 of 33
    11. 11. Simulation Models Surgical Theater LLC VR with Multi-sensory Feedback Phantom Haptic Stylus and Surgical Rehersal Platform (SRP). http://www.3dsystems.com/learning-center/case-studies/doctors-practicing-computers-not-patients#.UiXVNT95ESY Biomedical Modeling, Inc. ♦ 2013 11 of 33
    12. 12. Simulation Models Biomedical Modeling, Inc. | University of IL, Peoria Pediatric Neurosurgical Training Upper left: http://www.cdc.gov/ncbddd/spinabifida/facts.html. Right: Biomedical Modeling, Inc. & Univ. of Illinois College of Medicine, Peoria. J. Lin et. al., “A Surgical Simulation Model for Myelomeningocele Repair,” J. Med. Devices 7(2), 020924 (Jun 12, 2013). Biomedical Modeling, Inc. ♦ 2013 12 of 33
    13. 13. Surgical Guides Biomedical Modeling, Inc. ♦ 3D Diagnostix Biomodels & Dental Drilling Guides Biomedical Modeling, Inc. ♦ 2013 13 of 33
    14. 14. Surgical Guides Biomedical Modeling, Inc. Reconstructive Surgery Patient-specific model with tumor in red Biomedical Modeling, Inc. ♦ 2013 Reconstruction model guide with mirrored anatomy 14 of 33
    15. 15. Surgical Guides Biomedical Modeling, Inc. ♦ Beth Israel Deaconess Med. Center Tumor Resection vs. Liver Transplant Biomedical Modeling, Inc. ♦ 2013 15 of 33
    16. 16. Personalized Prosthetics Materialise ♦ Starkey Patient-specific Hearing Aids Left: http://i.materialise.com/blog/entry/3d-printing-in-medicine-what-is-happening-right-now-in-patients ; Right: http://www.forbes.com/sites/rakeshsharma/2013/07/08/the-3d-printing-revolution-you-have-not-heard-about/ Biomedical Modeling, Inc. ♦ 2013 16 of 33
    17. 17. Personalized Prosthetics Invisalign Orthodontic Tooth Aligners Left: http://www.rothmoonortho.com/kansas-city-orthodontic-treatment/kansas-city-invisalign/ ; Upper right: http://www.additive3d.com/rm_30.htm ; Lower right: http://enhancedental.com/invisalign/invisalign-procedure/ Biomedical Modeling, Inc. ♦ 2013 17 of 33
    18. 18. Personalized Prosthetics 3D Systems Custom Bridges, Copings, & Partial Dentures Left: 3D Systems, e-stone material on ProJet 6000 system. http://silversmilesurvival.wordpress.com/tag/3d-printing/ ; Upper right: http://3dsystems.intercept-corp.com/ProJet-DP-3500.html ; Lower right: www.dentalproductsreport.com Biomedical Modeling, Inc. ♦ 2013 18 of 33
    19. 19. Personalized Prosthetics Bespoke Innovations Prosthetic Limb Fairings “Why are you trying to hide it? Let’s show this thing off.” http://www.bespokeinnovations.com Biomedical Modeling, Inc. ♦ 2013 19 of 33
    20. 20. Personalized Prosthetics Berkley Bionics ♦ Ekso Bionics Powered Exoskeleton http://eksobionics.com/ekso Biomedical Modeling, Inc. ♦ 2013 20 of 33
    21. 21. Personalized Prosthetics Nemours/Alfred I. duPont Hospital for Children Patient-specific Exoskeleton Delaware Hospital, Mfg. Stratasys Corp., LAECO Othopedics. Left: Video still from http://www.youtube.com/watch?v=WoZ2BgPVtA0&feature=youtu.be ; Upper right: http://www.stratasys.com/resources/case-studies/medical/nemours ; Lower right: http://www.fastcodesign.com/1670482/3-d-printed-magicarms-let-a-toddler-hug-and-play#6 Biomedical Modeling, Inc. ♦ 2013 21 of 33
    22. 22. Patient-specific Implants Biomedical Modeling, Inc. Craniofacial Templates Biomedical Modeling, Inc. ♦ 2013 22 of 33
    23. 23. Patient-specific Implants Biomedical Modeling, Inc. ♦ Planmeca Oy Orbital Templates Left: Biomedical Modeling, Inc., Boston, MA, USA. http://www.biomodel.com Right: Planmeca Oy, Helsinki, FIN. http://www.planmeca.com/en/CADCAM/Planmeca-Promodel-service/ Biomedical Modeling, Inc. ♦ 2013 23 of 33
    24. 24. Patient-specific Implants EOS ♦ Oxford Performance Materials Direct Additive Manufacturing of Cranial Plates PEKK Left: http://www.eos.info/news_events/newsletter/edition_08_2012 ; Upper right: http://polymerinnovationblog.com/3d-printing-ofmedical-implants-is-on-the-way/; Lower right: http://www.makepartsfast.com/2009/03/710/new-materials-for-laser-sintering/ Biomedical Modeling, Inc. ♦ 2013 24 of 33
    25. 25. Patient-specific Implants Hasselt University ♦ LayerWise ♦ Xiloc Medical Direct Additive Manufacturing of Maxillofacial Implants Implant 3D-printed from powedered Ti with bioceramic coating, to replace mandible damaged due to osteomyelitis infection. Right: http://www.futureearth.com.au/science/3d-printing-woman-receives-jaw-implant/ ; Left: Yorick Jansens, AFP Collection, Getty Images 138078671, February 2, 2012. Biomedical Modeling, Inc. ♦ 2013 25 of 33
    26. 26. Patient-specific Implants Within Medical ♦ EOS Metal-sintered Orthopedic Implants Upper left: http://www.nsf.gov/od/lpa/news/02/3dprinttip_images.htm. Right, lower left: EOS, Within. Titanium acetabular cup implant and spinal implants manufactured by DMLS systems. http://gfxspeak.com/2012/10/17/eos-teams-with-medical-implant-designer-to-advance-3d-printing-inmedicine/ Biomedical Modeling, Inc. ♦ 2013 26 of 33
    27. 27. Guided Tissue Regeneration G. Green, S. Hollister, University of Michigan Printed Resorbable Trachea Splint Polycaprolactone printed trachea splint for 6-week olf patient with collapsed bronchial tube at C.S. Mott Childrens Hospital. http://www.engin.umich.edu/college/about/news/stories/2013/may/3d-printed-splint-saves-life Biomedical Modeling, Inc. ♦ 2013 27 of 33
    28. 28. Bio-printed Tissues & Organs L. Bonassar, Weill Cornell Medical College Artificial Ears from 3D-printed Molds Lindsay France | University Photography. http://www.news.cornell.edu/stories/2013/02/bioengineers-physicians-3-d-print-ears-look-act-real Cells from cow ears (collagen scaffold from rat tails) encapsulated in a hydrogel, and injected into mold. Biomedical Modeling, Inc. ♦ 2013 28 of 33
    29. 29. Bioprinted Tissues & Organs Univ. of Pennsylvania ♦ Organovo ♦ Invetech Bioprinted Blood Vessels Left and upper right: Rep Rap 3D Printing Blood vessels, http://www.youtube.com/watch?v=9VHFlwJQIkE ; Lower right: Printed from NovoGen MMX Bioprinter. http://www.oldthinkernews.com/2010/12/first-fully-bioprinted-blood-vessels/ ; http://iopscience.iop.org/1758-5090/4/2/022001/article Biomedical Modeling, Inc. ♦ 2013 29 of 33
    30. 30. Bioprinted Tissues & Organs A. Atala, Wake Forest Institute for Regenerative Medicine 3D-printed Liver Tissue Engineering Human Liver Tissue, Anthony Atala: Printing a Human Kidney, Ted Talks Ted2011. http://www.ted.com/talks/anthony_atala_printing_a_human_kidney.html Biomedical Modeling, Inc. ♦ 2013 30 of 33
    31. 31. Bioprinted Tissues & Organs Bio-printed organs to date Bladder Kidneys Liver Heart Valves Blood vessels Nerve Grafts, Skin A. Atala, Wake Forest Institute. http://www.bbc.com/ future/story/20120621-printing-a-human-kidney Biomedical Modeling, Inc. ♦ 2013 31 of 33
    32. 32. Why Anatomical Engineering? Anatomical engineering for medical device design, simulation, and testing. Biomedical Modeling, Inc. ♦ 2013 32 of 33
    33. 33. Why Anatomical Engineering? Anatomical engineering for tissue and organ replacement. Left: Rendering of 3D skull model with cranial implant, www.biomodel.com ; Right: Rendering of 3D printing skin cells onto burn wound, a method currently undergoing clinical trials in mice at Wake Forest Institute. http://www.3dprinterworld.com/article/wake-forest-3d-prints-skin-cells-burn-wounds Biomedical Modeling, Inc. ♦ 2013 33 of 33

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