19. Local vascular cells mildly oxidize the LDL accumulated in the subendothelial extracellular space to a form known as
minimally modified LDL, which is able to stimulate the recruitment of monocytes and eventual deposition of macrophages.
These further oxidize the LDL accumulated in the subendothelial extracellular space to a form that can be scavenged and
internalized, resulting in so-called foam cells. Such cells form the earliest visible lesion of atherosclerosis, the fatty streak.
43. Quercetin reduces blood pressure in
hypertensive subjects. J Nutr. 2007 Nov;137(11):2405-11.
สารเคอซิติน สามารถลดความดันโลหิตสูง
• Division of Nutrition, University of Utah, Salt Lake City, UT 84112, USA.
Epidemiological studies report that quercetin, an antioxidant flavonol found in
apples, berries, and onions, is associated with reduced risk of coronary
heart disease and stroke. และสามารถลดความเสี่ยงของโรคเสน
เลือดหัวใจ และสมอง ตีบตัน
• Quercetin supplementation also reduces blood pressure in hypertensive rodents. The
efficacy of quercetin supplementation to lower blood pressure in hypertensive
humans has never been evaluated.
48. • Garlic consumption and cancer prevention: meta-analyses
of colorectal and stomach cancers. American Journal of
Clinical Nutrition, Vol. 72, No. 4, 1047-1052, October 2000
• Garlic for treating hypercholesterolemia. A meta-analysis of
randomized clinical trials. Ann Intern Med. 2001 Jul
3;135(1):65-6
• Effect of garlic and fish-oil supplementation on serum lipid
and lipoprotein concentrations in hypercholesterolemic
men. Am J Clin Nutr. 1997 Feb;65(2):445-50
• The antiatherosclerotic effect of Allium sativum.
Atherosclerosis. 2000 Jun;150(2):437-8.
49. Garlic for treating hypercholesterolemia. A meta-
analysis of randomized clinical trials.
• PURPOSE: To investigate the effect of garlic on total cholesterol level in persons with elevated
levels by conducting a meta-analysis of randomized, double-blind, placebo-controlled trials.
• SELECTION: randomized, double-blind, and placebo-controlled; use garlic monopreparations;
include persons with mean total cholesterol levels of at least 5.17 mmol/L (200 mg/dL)
• DATA SYNTHESIS: In the 13 trials included in the meta-analysis, garlic reduced total
cholesterol level from baseline significantly more than placebo (P < 0.01); the weighted mean
difference was -0.41 mmol/L (95% CI, -0.66 to -0.15 mmol/L) (-15.7 mg/dL [CI, -25.6 to -5. 7
mg/dL]). Six diet-controlled trials with the highest scores for methodologic quality revealed a
nonsignificant difference between garlic and placebo groups; the weighted mean difference was -
0.11 mmol/L (CI, -0.30 to 0.08 mmol/L) (-4.3 mg/dL [CI, -11.7 to 3.1 mg/dL]).
• CONCLUSIONS: The available data suggest that garlic is superior to
placebo in reducing total cholesterol levels. However, the size of the effect is
modest, and the robustness of the effect is debatable. The use of garlic for hypercholesterolemia
is therefore of questionable value.
Ann Intern Med. 2000 Sep 19;133(6):420-9.
57. Antihyperlipemic and antihypertensive effects of
Spirulina maxima in an open sample of Mexican
population: a preliminary report. Lipids Health Dis. 2007
Nov 26;6:33. สาหรายมีฤทธิ์ ลดไขมันในเลือดและความดันโลหิต
• 36 subjects (16 men and 20 women, with ages between 18-65 years) 4.5
g/day, for 6 weeks
• TAG 233.7 +/- 177.8 vs. 167.7 +/- 100.7 mg/dL (p < 0.001), TC 181.7 +/-
37.5 vs. 163.5 +/- 34.4 mg/dL (p < 0.001), C-HDL 43.5 +/- 14.4 vs. 50 +/-
18.8 mg/dL (p < 0.01).
• SYST-P male 121 +/- 9 vs. 111 +/- 8 mm Hg (p < 0.01), DIAST-P male 85
+/- 6.5 vs. 77 +/- 9 mm Hg (p < 0.01); SYST-P female 120 +/- 9.5 vs. 109
+/- 11 mm Hg (p < 0.002), DIAST-P female 85 +/- 11 vs. 79 +/- 7.5 mm Hg
(p < 0.03).
61. Beta-carotene and risk of coronary heart disease. A
review of observational and intervention studies.
Biomed Pharmacother. 1999 Oct;53(9):409-16. เบตา
คาโลทีน ลดความเสียงโรคหัวใจ
่
• Six cohort studies reported relative risks (RR) of CHD between
0.27 and 0.78 for high beta-carotene levels (plasma/serum levels
and dietary intake), but four more recent ones reported RR around
unity (range 0.84 to 1.19). The evidence from case-control studies
supports a role of beta-carotene in the prevention of CHD (odds
ratios, OR, between 0.37 and 0.71), with a possible stronger
protection for current smokers.
63. Serum lycopene concentrations and carotid
atherosclerosis: the Kuopio Ischaemic Heart Disease
Risk Factor Study. Am J Clin Nutr. 2003 Jan;77(1):133-8.
ระดับ โลโคปน ในเลือด และ การเกิด เสนเลือดตีบตัน
• We investigated the relation between serum lycopene
concentration and CCA-IMT in 1028 middle-aged men
(aged 46-64 y) in eastern Finland who were participants
in the Kuopio Ischaemic Heart Disease Risk Factor
study and who were examined in 1991-1993. The
subjects were classified into quarters according to serum
lycopene concentration.
64. Serum lycopene concentrations and carotid
atherosclerosis: the Kuopio Ischaemic Heart Disease
Risk Factor Study. Am J Clin Nutr. 2003 Jan;77(1):133-8.
• RESULTS: In a covariance analysis with adjustment for covariates,
the men in the lowest quarter of serum lycopene concentration had a
significantly higher mean CCA-IMT and maximal CCA-IMT (P =
0.005 and P = 0.001 for the difference, respectively) than did the
other men. The mean and maximal CCA-IMT increased linearly
across the quarters of serum lycopene concentration.
• ระดับไลโคปนต่ํามีผลตอ การเพิ่มความตีบตันของเสนเลือดที่คอ ใน
การศึกษาใน ผูปวย
65. Serum lycopene concentrations and carotid
atherosclerosis: the Kuopio Ischaemic Heart Disease
Risk Factor Study. Am J Clin Nutr. 2003 Jan;77(1):133-8.
• CONCLUSIONS: A low serum lycopene concentration is associated with a
higher CCA-IMT in middle-aged men from eastern Finland. This finding
suggests that the serum lycopene concentration may play a role in the early
stages of atherosclerosis. Increased thickness of the intima-media has been
shown to predict coronary events; thus, lycopene intakes and serum
concentrations may have clinical and public health relevance.
ระดับไลโคปนต่ํามีผลตอ การเพิ่มความตีบตันของเสนเลือดที่คอ ใน
การศึกษาใน ผูปวย
66. Tomatoes and cardiovascular health.
Crit Rev Food Sci Nutr. 2003;43(1):1-18.
มะเขือเทศ มีผล ตอโรคหัวใจ
• Tomatoes, the second most produced and consumed vegetable
nationwide, are a rich source of lycopene, beta-carotene, folate,
potassium, vitamin C, flavonoids, and vitamin E.
• Other cardioprotective functions provided by the nutrients in
tomatoes may include the reduction of low-density lipoprotein (LDL)
cholesterol, homocysteine, platelet aggregation, and blood pressure.
• Because tomatoes include several nutrients associated with
theoretical or proven effects and are widely consumed year round,
they may be considered a valuable component of a cardioprotective
diet.
68. • Because free-radical-mediated peroxidation of membrane
lipids and oxidative damage of DNA and proteins are believed
to be associated with a variety of chronic pathological
complications such as cancer, atherosclerosis, and
neurodegenerative diseases, curcumin is thought to play a
vital role against these pathological conditions. Antioxidant
and anti-inflammatory properties of curcumin.
Adv Exp Med Biol. 2007;595:105-25.
• การตานอนุมูลอิสระ และการอักเสบของขมิ้น เชื่อวา
อาจมีผลตอโรค มะเร็ง เสนเลือดหัวใจ และสมองเสื่อม
69. • Curcuma longa extract supplementation
reduces oxidative stress and attenuates aortic
fatty streak development in rabbits
Arterioscler Thromb Vasc Biol. 2002 Jul
1;22(7):1225-31
• สารสกัดจากขมินชัน ลด การเกิดอนุมูลอิสระ และ
้
ตะกอนในเลือดในเสนเลือดของกระตาย
74. Antiproliferative effect of curcumin (diferuloylmethane) against human
breast tumor cell lines. Anticancer Drugs. 1997 Jun;8(5):470-81.
-ขมิ้นยับยั้ง เซลลมะเร็งเตานมหลายชนิด
• We examined the antiproliferative effects of curcumin against several breast
tumor cell lines, including hormone-dependent and -independent
and multidrug-resistant (MDR) lines.
• All the cell lines tested, including the MDR-positive ones, were highly
sensitive to curcumin. The growth inhibitory effect of curcumin was time- and
dose-dependent, and correlated with its inhibition of ornithine decarboxylase
activity. Curcumin preferentially arrested cells in the G2/S phase of the cell
cycle….
• . Overall our results suggest that curcumin is a potent
antiproliferative agent for breast tumor cells and may have
potential as an anticancer agent.
75.
76.
77. สาเหตุหลักอยางหนึ่ง ของมะเร็งปากมดลูกคือ เชื้อไวรัส
ตระกูลหูด HPV
• มากกวา 99 % ของมะเร็งปากมดลูก จะพบเชื้อ HPV
• More than 99% of all cervical cancers contain high risk HPV.
Only a persistent infection with high risk HPV of the cervical
epithelium results in cervical cancer . Ned Tijdschr Geneeskd.
2000 Aug 26;144(35):1675-9.
• HPV is now accepted as the primary cause of cervical neoplasia
and accounts for most of the risk factors traditionally associated
with this disease Clin Lab Med. 2000 Jun;20(2):257-70, v.
78. ขมิ้น ยับยั้งเชื้อ HPV และอาจจะลดมะเร็งปากมดลูก
• Constitutive activation of transcription factor AP-1 in
cervical cancer and suppression of human papillomavirus
(HPV) transcription and AP-1 activity in HeLa cells by
curcumin. Int J Cancer. 2005 Mar 1;113(6):951-60.
เคอคิวมินในขมิน ยับยั้ง เชื้อ ไวรัส HPV ซึ่งเปนสาเหตุหลักของ
้
มะเร็งปากมดลูก
• Antitumor action of curcumin in human papillomavirus
associated cells involves downregulation of viral oncogenes,
prevention of NFkB and AP-1 translocation, and
modulation of apoptosis. Mol Carcinog. 2006 May;45(5):320-32.
กลไกการลดมะเร็งปากมดลูกของขมินโดยยับยั้ง HPV
้
79. Constitutive activation of transcription factor AP-1 in cervical
cancer and suppression of human papillomavirus (HPV)
transcription and AP-1 activity in HeLa cells by curcumin.
Int J Cancer. 2005 Mar 1;113(6):951-60.
• We demonstrate for the first time that curcumin can
selectively downregulate HPV18 transcription as well
as the AP-1 binding activity in HeLa cells.
• Our study thus provides a basis for developing a
novel therapeutic approach to control pathogenic
HPV infection by using potent antioxidative agents,
such as curcumin.
85. Antiproliferation and apoptosis induced by
curcumin in human ovarian cancer cells.
ขมิ้นยับยั้ง เซลลมะเร็งรังไข
• Cell Biol Int. 2006 Mar;30(3):221-6. Epub 2005 Dec.
• In the present study, we have investigated the effects of curcumin on growth
and apoptosis in the human ovarian cancer cell line Ho-8910 by
MTT assay, fluorescence microscopy, flow cytometry and Western blotting.
• Our data revealed that curcumin could significantly inhibit the
growth and induce apoptosis in Ho-8910 cells. A decrease in
expression of Bcl-2, Bcl-X(L) and pro-caspase-3 was observed after exposure
to 40 microM curcumin, while the levels of p53 and Bax were increased in the
curcumin-treated cells.
• These activities may contribute to the anticarcinogenic action of curcumin.
88. Preventive role of curcumin in lung cancer
ขมิ้นยับยั้งมะเร็งปอด ลิวคีเมีย ตอมลูกหมาก
• Przegl Lek. 2005;62(10):1180-1.
• Carcinogens from cigarette smoke form the link between nicotine
addiction and lung cancer, which is the leading cause of cancer-related
mortality in the world. One of the most frequently studied
chemopreventive agents is a curcumin, a natural compound
extracted from turmeric that inhibits cell proliferation and
induces apoptosis in human leukaemia, prostate cancer, and non-
small cell lung cancer. Curcumin (diferuoylmethane) is a major yellow
pigment in turmeric (Curcuma longa) and is widely used as a spice. Curcumin
exhibits a variety of pharmacological effects, and has been
reported to have anti-inflammatory and anti-tumor activities.
90. • เคอรคิวมินในขมิ้น มีฤทธิ์ ยับยั้ง และทําลายเซลลมะเร็ง ลําไสใหญ ( Human
colon adenocarcinoma ) ของมนุษยได Braz J Med Biol Res. 2005
Dec;38(12):1791-8. Epub 2005 Nov 9. Curcumin induces human HT-29
colon adenocarcinoma cell apoptosis by activating p53 and regulating
apoptosis-related protein expression.
• In the present study, we examined the effects of curcumin on the proliferation
of human colon adenocarcinoma HT-29 cells The colon adenocarcinoma cells
were treated with curcumin (0-75 microM) for 0-24 h.
• Curcumin could also down-regulate the expression of pro-caspase-3 and pro-
caspase-9 in a time-dependent manner. These data suggest a possible
underlying molecular mechanism whereby curcumin could induce the apoptosis
signaling pathway in human HT-29 colon adenocarcinoma cells by p53
activation and by the regulation of apoptosis-related proteins. This property of
curcumin suggests that it could have a possible therapeutic potential in colon
adenocarcinoma patients.
91. Curcumin inhibits human colon cancer cell growth by suppressing
gene expression of epidermal growth factor receptor through
reducing the activity of the transcription factor Egr-1.
เคอคิวมินในขมิ้นยับยั้ง มะเร็ง ลําไส . Oncogene. 2006 Jan 12;25(2):278-87
• Electrophoretic mobility shift assays demonstrated that curcumin
significantly reduced the DNA-binding activity of the transcription
factor Egr-1 to the curcumin response element. ….
• These results provided novel insights into the mechanisms of curcumin
inhibition of colon cancer cell growth and potential therapeutic
strategies for treatment of colon cancer.
93. Effects of curcumin on proliferation and apoptosis in
human hepatic cells. เคอคิวมิน มีผลยับยั้ง เซลลมะเร็งตับ
• Zhonghua Gan Zang Bing Za Zhi. 2002 Dec;10(6):449-51.
• OBJECTIVE: To investigate the effect of curcumin on the proliferation, cell
cycle distribution and apoptosis of hepatocarcinoma cell line QGY.
METHODS: The MTT method was used to assay the biologic activities of
curcumin in different times and different doses. The cell cycle distribution
was detected by flow cytometic analysis. The cell ultrastructure was observed
by electronic microscopy. RESULTS: Curcumin could inhibit effectively
QGY in a dose- and time- dependent manner. IC(50) of curcumin to QGY
was 49.50 micromol/L in 72 hours. The cell growth was arrested at S stage.
Curcumin could lead to the degeneration, necrosis, and apoptosis.
CONCLUSIONS: Curcumin can interrupt the cell cycle and has a role in
cytotoxicity, antiproliferation and inducing apoptosis of QGY.
94. The effects of curcumin on the invasiveness of
prostate cancer in vitro and in vivo. Prostate Cancer
Prostatic Dis. 2006 Jan 3; ขมิ้นยับยั้งมะเร็งตอมลูกหมาก
• In this study, we evaluated the effects of curcumin on prostate cancer cells
(DU-145) invasion in both in vitro and in vivo.
• We utilized zymography and ELISA in order to determine the MMP-2 and
MMP-9 activity.
• Curcumin was shown to induce a marked reduction of tumor volume,
MMP-2, and MMP-9 activity in the tumor-bearing site. The metastatic
nodules in vivo were significantly fewer in the curcumin-treated group
than untreated group. Curcumin appears to constitute a potential agent for
the prevention of cancer progression, or at least of the initial phase of
metastasis, in prostate cancer.
95. • เคอรคิวมินในขมิ้น มีฤทธิ์ ยับยั้ง และทําลายเซลลมะเร็ง ผิวหนัง (
melanoma ) ของมนุษยได Apoptosis induced by curcumin and its
effect on c-myc and caspase-3 expressions in human melanoma
A375 cell line. Di Yi Jun Yi Da Xue Xue Bao. 2005
• OBJECTIVE: To investigate the effect of curcumin on cell
apoptosis and c-myc and caspase-3 expressions in human
melanoma A375 cell line. METHODS: A375 cells were exposed
to curcumin treatment and growth inhibition of the cells was
examined by MTT assay
• CONCLUSION: Curcumin can inhibit the proliferation and
induce apoptosis of A375 cells in vitro, and the genes encoding c-
myc and caspase-3 may play a role in the process.
97. Tea catechin consumption reduces circulating
oxidized low-density lipoprotein.
Int Heart J. 2007 Nov;48(6):725-32.
• Department of Internal Medicine, Chiba-Hokusoh
Hospital, Nippon Medical School, Chiba, Japan.
สารสกัดจากชาเขียว สามารถลด ออกซิไดซ แอลดีแอล ซึ่ง
เปนกลไกในการลดโรคหัวใจหลอดเลื่อด
98. Tea catechin consumption reduces circulating
oxidized low-density lipoprotein.
Int Heart J. 2007 Nov;48(6):725-32.
• The subjects were randomly divided into two groups, a catechin
group (n = 29) and a control group (n = 11).
• In the catechin group, catechin (500 mg: equivalent to 6 or 7 cups of
green tea) was administered orally.
• Venous blood samples were obtained before eating a meal at the start
and after 4 weeks without any lifestyle modification. Plasma oxidized
LDL assay was performed with a sandwich-type enzyme
immunoassay using anti-oxidized phosphatidylcholine monoclonal
antibody. The baseline lipid profiles and tea consumptions were
similar between the two groups.
99. Tea catechin consumption reduces circulating
oxidized low-density lipoprotein.
Int Heart J. 2007 Nov;48(6):725-32.
• Plasma oxidized LDL was significantly decreased after
catechin administration ระดับ ออกซิไดซแอลดีแอลลดลงอยาง
มีนยสําคัญ (from 9.56 +/- 9.2 to 7.76 +/- 7.7 U/mL, P =
ั
0.005), while plasma LDL-C, triglyceride, and HDL-C
concentrations did not change. Catechin decreased the plasma
oxidized LDL concentration without significant change in
plasma LDL concentration. The mechanism of the beneficial
effects of green tea on coronary artery disease might result
from a decrease in plasma oxidized LDL.
106. Ganoderma lucidum
• The anti-tumor effect of Ganoderma lucidum
is mediated by cytokines released from activated macrophages and
T lymphocytes. Int J Cancer 1997; 70: 699-705.
• Dietary effect of Ganoderma lucidum mushroom on blood pressure
and lipid levels in spontaneously hypertensive rats (SHR). J Nutr
Sci Vitaminol (Tokyo) 1988; 34: 433-438.
• Cardiovascular effects of mycelium extract of Ganoderma lucidum:
inhibition of sympathetic outflow as a mechanism of its hypotensive
action. Chem Pharm Bull (Tokyo) 1990; 38: 1359-1364.
• Mechanisms of hypoglycemic activity of ganoderan B: a glycan of
Ganoderma lucidum fruit bodies. Planta Med 1989; 55: 423-428.
107. Ganoderma lucidum
ยั้บยั้ง ไวรัส เอดส HIV-1
• Anti-HIV-1 and anti-HIV-1-protease
substances from Ganoderma lucidum.
Phytochemistry 1998; 49: 1651-1657.
• Triterpenes from the spores of Ganoderma lucidum and their
inhibitory activity against HIV-1 protease. Chem Pharm Bull
(Tokyo) 1998; 46: 1607-1612.
• Praphan Phanuphak .Clinical Study of Micronized Reishi
Mushroom in Thai HIV Patients. Faculty of Medicine,
Chulalongkorn University, Thailand
108. Ganoderma lucidum
• บํารุงตับ Radical scavenger and antihepatotoxic activity of
Ganoderma formosanum, Ganoderma lucidum and Ganoderma
neo-japonicum. J Ethnopharmacol 1995; 47: 33-41.
• Beta-glucuronidase-inhibitory activity and hepatoprotective
effect of Ganoderma lucidum . Biol Pharm Bull 1999; 22: 162-
164.
• สงเสริมภูมตานทาน Ling Zhi-8: studies of a new
ิ
immunomodulating agent. Transplantation 1995; 60: 438-443.
• ลดการเจ็บแผลงูสวัด Effect of Ganoderma lucidum on
postherpetic neuralgia . Am J Chin Med 1998; 26: 375-381.
109. เห็ดหลินจือ ยับยั้ง เซลลมะเร็งเตานม
• เห็ดหลินจือสามารถยับยั้งการเจริญเติบโต เซลลมะเร็งเตานม
ของมนุษยไดทงชนิดที่ตอบสนองตอ เอสโตรเจน estrogen-
ั้
dependent (MCF-7) และชนิดที่ไมตอบสนอง ตอ เอสโต
รเจน estrogen-independent (MDA-MB-231) breast
cancer cells
• Ganoderma lucidum inhibits proliferation of human
breast cancer cells by down-regulation of estrogen
receptor and NF-kappaB signaling. Int J Oncol. 2006
Sep;29(3):695-703.
111. สารสกัดเห็ดหลินจือ ชวยเพิ่มภูมิตานทาน
เซลลมะเร็งในผูปวยมะเร็งลําไสใหญระยะลุกลาม
• Monitoring of immune responses to a herbal immuno-modulator
in patients with advanced colorectal cancer.
Int Immunopharmacol. 2006 Mar;6(3):499-508. Epub 2005 Sep 15.
• in patients with advanced colorectal cancer. Forty-seven patients
were enrolled and treated with oral G. lucidum at 5.4 g/day for 12
weeks. Selected immune parameters were monitored ….
• The results indicate that G. lucidum may have potential immuno-
modulating effect in patients with advanced colorectal cancer. Further
studies are needed to explore the benefits and safety of G. lucidum in
cancer patients.
113. เห็ดหลินจือ ยับยั้งการเจริญของเซลลมะเร็ง
เม็ดเลือดขาว human leukemia HL-60 cells
• Enhanced induction of mitochondrial
damage and apoptosis in human leukemia
HL-60 cells by the Ganoderma lucidum and
Duchesnea chrysantha extracts. Cancer Lett.
2006 Mar 27
120. Progression of carotid intima-media thickness and plasma
antioxidants: the Los Angeles Atherosclerosis Study. Arterioscler
Thromb Vasc Biol. 2004 Feb;24(2):313-9. Epub 2003 Dec 1.
• การตีบเพิ่มของโรคเสนเลือดหัวใจอุดตัน กับระดับ สารตาน
อนุมูลอิสระในเลือด
• cohort of 573 middle-aged women and men who were free of symptomatic
cardiovascular disease at baseline. Ultrasound examination of the common
carotid arteries, lipid level determination, and risk factor assessment were
performed
• ตรวจในผูปวย 573 คน
121. Progression of carotid intima-media thickness and plasma
antioxidants: the Los Angeles Atherosclerosis Study. Arterioscler
Thromb Vasc Biol. 2004 Feb;24(2):313-9. Epub 2003 Dec 1.
• การตีบเพิ่มของโรคเสนเลือดหัวใจอุดตัน กับระดับ สารตาน
อนุมลอิสระในเลือด
ู
• 18-month change in IMT was significantly inversely related to the 3
measured oxygenated carotenoids (lutein, beta-cryptoxanthin,
zeaxanthin; P<0.02 for all)
• 18 เดือน ผานไปพบวา การตีบเพิ่ม จะลดนอยลงในกลุมที่มี
ระดับ ลูทิน ซีแซนทีน และ เบตา คลิปโตแซนทีน สูง
• .
128. Lutein, but not alpha-tocopherol, supplementation
improves visual function in patients with age-related
cataracts: a 2-y double-blind, placebo-controlled
pilot study. Nutrition. 2003 Jan;19(1):21-4.
• dietary supplementation with lutein (15 mg; n = 5), alpha-
tocopherol (100 mg; n = 6), or placebo (n = 6), three times a week
for up to 2 y.
• Visual performance (visual acuity and glare sensitivity) improved
in the lutein group, whereas there was a trend toward the
maintenance of and decrease in visual acuity with alpha-tocopherol
and placebo supplementation, respectively.
• ชวยใหสายตาดีขึ้น ในผูปวย โรคตอกระจก
129. A prospective study of carotenoid intake and risk of
cataract extraction in US men.
ลดตอกระจก 19% Am J Clin Nutr. 1999 Oct;70(4):517-24.
• US male health professionals (n = 36644) who were 45-75 y of age
• Men in the highest fifth of lutein and zeaxanthin intake had a 19%
lower risk of cataract relative to men in the lowest fifth
• CONCLUSIONS: Lutein and zeaxanthin may decrease the
risk of cataracts severe enough to require extraction,
although this relation appears modest in magnitude. The present
findings add support for recommendations to consume vegetables
and fruit high in carotenoids daily.
130. A prospective study of carotenoid and vitamin A
intakes and risk of cataract extraction in US women.
Am J Clin Nutr. 1999 Oct;70(4):509-16.
ลดตอกระจก 22 %
• 50461 were included and others were added as they became 45 y
of age for a total of 77466.
• those with the highest intake of lutein and zeaxanthin had a 22%
decreased risk of cataract extraction compared with those in the
lowest quintile
• CONCLUSIONS: Lutein and zeaxanthin and foods rich in these
carotenoids may decrease the risk of cataracts severe enough to
require extraction.
138. The antiatherosclerotic effect of Allium sativum.
Atherosclerosis. 2000 Jun;150(2):437-8.
• กระเทียม ลดการเกิดตะกอน Plaque 6-13%
In a randomized, double-blind, placebo-controlled clinical trial, the plaque volumes in
both carotid and femoral arteries of 152 probationers were determined by B-mode
ultrasound. Continuous intake of high-dose garlic powder dragees reduced significantly
the increase in arteriosclerotic plaque volume by 5-18% or even effected a slight
regression within the observational period of 48 months. Also the age-dependent
representation of the plaque volume shows an increase between 50 and 80 years that is
diminished under garlic treatment by 6-13% related to 4 years. It
seems even more important that with garlic application the plaque volume in the whole
collective remained practically constant within the age-span of 50-80 years. These
results substantiated that not only a preventive but possibly also a curative role in
arteriosclerosis therapy (plaque regression) may be ascribed to garlic
remedies.
140. น้ําทับทิม POMEGRANATE
• มีสารตานอนุมูลอิสระหลายชนิด
• ลด ไขมันในเลือด ( J Nutr 2001 Aug )
• รักษาเสนเลือดที่หนาตัว
Artherosclerotic artery (Am J Clin Nutr 2000 May )
• ลดความดันโลหิต ในโรคความดันโลหิตสูง
• บํารุงตับ ปองกันการเปนพิษตอตับ ( J Agric Food Chem 2002 Aug )
• ยับยั้งของเซลลมะเร็งเตานม ( Breast Cancer Res Treat 2003;71(3):203-17.)
• ลดการบาดเจ็บของสมองเด็กจากการคลอด
• เสริมสมรรถภาพทางเพศ ในหนูเพศผู
141. ทับทิม POMEGRANATE
• Pomegranate juice consumption for 3 years
by patients with carotid artery stenosis
reduces common carotid intima-media
thickness, blood pressure and LDL oxidation
Clin Nutr. 2004 Jun;23(3):423-33.
• การรับประทานน้ําทับทิม เปนเวลา 3 ป ในผูปวยเสนเลือดที่คอ
ตีบ สามารถลดความหนาตัวของพลาคในเสนเลือด ความดัน
โลหิต และไขมันในเลือด
• The Lipid Research Laboratory, Rambam Medical Center, Haifa 31096,
Israel.
142. • In the control group that did not consume PJ, common carotid
intima-media thickness (IMT) increased by 9% during 1 year,
whereas, PJ consumption resulted in a significant IMT
reduction, by up to 30%, after 1 year.
• กลุมที่ไมไดรับประทานน้ําทับทิม ความตีบหนาของ
เสนเลือด เพิ่มขึ้น 9% ภายใน 1 ป แตกลุมที่ไดรับน้ํา
ทับทิม กลับลดลงอยางมีนยสําคัญถึง 30% ภายใน 1
ั
ป
• Clin Nutr. 2004 Jun;23(3):423-33.
143. ทับทิมยับยั้ง
เซลล มะเร็งเตานม
Breast cancer
MCF-7 (Human breast adenocarcinoma cell line)
