Discovery Otto WarburgRichard Kuhn Paul Karrer Germany Switzerland Nobel prize Nobel prize 1937 1938
Riboflavin is...Ribose= sugar, ribitol Flavin= latin word flavus for “yellow” Yellow, water soluble B-complex vitamin Has may functions http://www.youtube.com/watch? v=tBwmacEkV94
FunctionsMetabolism of carbohydrates, fats & proteinsNormal growth and developmentImmune systemVision, eye fatigue, eye lens, cataracts preventionMigraine headaches Athletic performance Required for activation/Healthy skin, hair, nails support of B6, folate, niacin, vitamin KAntioxidant propertiesNervous system Proper function of RBC
Energy Metabolism Coenzyme forms FMN Flavoproteins FADFlavin mononucleotide Flavin adenine dinucleotide FAD <-------> FADH2
Antioxidant productionGlutathione: antioxidant responsible for preventingcellular & tissue damage from oxidation.Riboflavin allows Glutathione Recycling to take place.Riboflavin is the cofactor for Glutathione Reductaseenzyme.
Migraines & Athletic performanceCan reduce both attack Athletes had sufficientfrequency & number of B2 concentrationsdays with migraine. Not compared to non- severity. athletes. 59%+ improvements with 400 mg
Ariboflavinosis Deficiency in RiboflavinPrimary B2 deficiency: Poor vitamin sources in onesdaily diet.Secondary B2 deficiency: Conditions that affectabsorption in the intestine, body can’t use vitamin, orincrease of excretion.Always accompanied by deficiency in other vitamins.
Deficiency symptomsSore throat, cracks andredness at the corners ofmouth, painful/smooth/purple red tongue,inﬂammation characterizedby skin lesions covered Eyes become bloodshot,with greasy scales itchy, watery, sensitive to light
ToxicityLow solubility keeps B2 from being absorbed indangerous amounts.Excess amounts is excreted in the urine = Brightyellow.1998, Institute of Medicine at the NationalAcademy of science decided not to set a tolerableupper limit for Vitamin B2.