Riboflavin

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  • Riboflavin

    1. 1. Riboflavin Vitamin B2Li sa B od le
    2. 2. Discovery Otto WarburgRichard Kuhn Paul Karrer Germany Switzerland Nobel prize Nobel prize 1937 1938
    3. 3. Riboflavin is...Ribose= sugar, ribitol Flavin= latin word flavus for “yellow” Yellow, water soluble B-complex vitamin Has may functions http://www.youtube.com/watch? v=tBwmacEkV94
    4. 4. FunctionsMetabolism of carbohydrates, fats & proteinsNormal growth and developmentImmune systemVision, eye fatigue, eye lens, cataracts preventionMigraine headaches Athletic performance Required for activation/Healthy skin, hair, nails support of B6, folate, niacin, vitamin KAntioxidant propertiesNervous system Proper function of RBC
    5. 5. Energy Metabolism Coenzyme forms FMN Flavoproteins FADFlavin mononucleotide Flavin adenine dinucleotide FAD <-------> FADH2
    6. 6. Antioxidant productionGlutathione: antioxidant responsible for preventingcellular & tissue damage from oxidation.Riboflavin allows Glutathione Recycling to take place.Riboflavin is the cofactor for Glutathione Reductaseenzyme.
    7. 7. Repairs & maintains healthy...SkinHairNails
    8. 8. Eyes!Improves eyesight/eye healthReduces eye fatiguePrevents cataracts
    9. 9. Migraines & Athletic performanceCan reduce both attack Athletes had sufficientfrequency & number of B2 concentrationsdays with migraine. Not compared to non- severity. athletes. 59%+ improvements with 400 mg
    10. 10. RDA Recommended Dietary Allowance for Riboflavin (Vitamin B2)Life Stage! Age! Males (mg/day) ! Females (mg/day) 5-10% moreInfants! 0-6 months! 0.3! 0.3Infants! 7-12 months! 0.4 0.4Children! 1-3 years! 0.5! 0.5Children 4-8 years! 0.6! 0.6Children 9-13 years! 0.9! 0.9Adolescents 14-18 years! 1.3! 1.0Adults! 19-years and older! 1.3! 1.1Pregnancy! all ages! -! 1.4Breastfeeding! all ages! -! 1.6
    11. 11. Food SourcesLiver (calf) 3oz = 2.4 mg 2% Milk 1 cup= 0.4 mg King Mackerel 3oz= 0.5 mg Clams 3oz= 0.4 mgCereal 1oz= 0.4+ mg Plain yogurt 1 cup= 0.5 mg Soybeans 1cup= 0.5 mg
    12. 12. Ariboflavinosis Deficiency in RiboflavinPrimary B2 deficiency: Poor vitamin sources in onesdaily diet.Secondary B2 deficiency: Conditions that affectabsorption in the intestine, body can’t use vitamin, orincrease of excretion.Always accompanied by deficiency in other vitamins.
    13. 13. Deficiency symptomsSore throat, cracks andredness at the corners ofmouth, painful/smooth/purple red tongue,inflammation characterizedby skin lesions covered Eyes become bloodshot,with greasy scales itchy, watery, sensitive to light
    14. 14. ToxicityLow solubility keeps B2 from being absorbed indangerous amounts.Excess amounts is excreted in the urine = Brightyellow.1998, Institute of Medicine at the NationalAcademy of science decided not to set a tolerableupper limit for Vitamin B2.
    15. 15. Destruction .Ultraviolet lightIrradiation

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