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Tozal Webinar


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New Perspective on incorporation of total wellness within the medical practice

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Tozal Webinar

  1. 1. <ul><li>presents TOZAL ® </li></ul><ul><li>Eye Health Formula </li></ul>The new standard of care in the support of eye health. 877-720-2982 or
  2. 2. Age-Related Macular Degeneration <ul><li>15 million+ North Americans are affected by AMD </li></ul><ul><ul><li>14% of patients over 55 </li></ul></ul><ul><ul><li>25% of patients over 65 </li></ul></ul><ul><ul><li>37% of patients over 75 </li></ul></ul><ul><ul><li>66% of patients over 90 </li></ul></ul><ul><ul><li>100% of patients over 100 </li></ul></ul><ul><li>50 million+ North Americans are at risk for AMD </li></ul><ul><li>These numbers will increase by over 50% by 2020 </li></ul>
  3. 3. AMD Risk Factors <ul><li>Nonmodifiable </li></ul><ul><ul><li>Age </li></ul></ul><ul><ul><li>Heredity </li></ul></ul><ul><ul><li>Gender </li></ul></ul><ul><ul><li>Pigmentation </li></ul></ul><ul><ul><li>Race </li></ul></ul><ul><ul><li>Iris color </li></ul></ul><ul><li>Modifiable </li></ul><ul><ul><li>Smoking </li></ul></ul><ul><ul><li>Cardiovascular disease, blood lipid status, and hypertension </li></ul></ul><ul><ul><li>Alcohol consumption </li></ul></ul><ul><ul><li>Light exposure </li></ul></ul><ul><ul><li>Nutrition </li></ul></ul>
  4. 4. AREDS1 - 2001 <ul><li>AMD is in part a disease of oxidative stress, so antioxidant nutrients may play a role in protection against AMD. </li></ul><ul><li>25% experienced a “slowing” in loss of vision </li></ul><ul><li>75% of AMD patients who take an AREDS based supplement derive no benefit. </li></ul>AREDS1 Results
  5. 5. Nutrients Epidemiologically Linked to Decreased AMD Risk <ul><li>Antioxidant minerals </li></ul><ul><ul><li>Zinc </li></ul></ul><ul><li>Antioxidant vitamins </li></ul><ul><ul><li>Vitamin C </li></ul></ul><ul><ul><li>Vitamin E </li></ul></ul><ul><ul><li>Vitamin A </li></ul></ul><ul><li>Omega-3 Fatty Acids </li></ul><ul><ul><li>EPA/DHA from fish or </li></ul></ul><ul><ul><li>fish oil </li></ul></ul><ul><li>Carotenoids </li></ul><ul><ul><li>Lutein </li></ul></ul><ul><ul><li>Zeaxanthin </li></ul></ul><ul><ul><li> -Carotene </li></ul></ul><ul><li>Herbals </li></ul><ul><ul><li>Anthocyanadines </li></ul></ul><ul><ul><ul><li>Grape Seed Extract </li></ul></ul></ul><ul><ul><ul><li>Berry Extracts </li></ul></ul></ul><ul><ul><ul><ul><li>Billberry </li></ul></ul></ul></ul>
  6. 6. TOZAL Study T aurine / O mega-3 / Z inc / A ntioxidants / L utein <ul><li> </li></ul><ul><li>Patients: 74 Treated Eyes </li></ul><ul><li> 30 Placebo </li></ul><ul><li>Dry AMD: Acuity 20/32 – 20/125 </li></ul><ul><li>5 Independent U.S. Study Sites </li></ul><ul><ul><li>4 University Ophthalmology Centers </li></ul></ul><ul><ul><li>1 Private Vitreo-Retinal Practice </li></ul></ul><ul><li>Patients Followed for 6 - 24 Months </li></ul><ul><li>Treated Patients Gained An Average of 0.5 lines </li></ul><ul><li>Placebo Patients Lost An </li></ul><ul><li>Average of 1.5 lines </li></ul><ul><li>Net Gain of 2.0 lines </li></ul>
  7. 7. TOZAL Clinical Trial Results 76.7% Improved or Stabilized <ul><li>56.7% Experienced Improved Vision </li></ul><ul><li>20% Experienced Stable Vision </li></ul><ul><li>23.3% Continued To Worsen (Natural Disease Progression: No Worse Than Placebo) </li></ul>
  8. 8. The Macular Xanthophylls <ul><li>Lutein and zeaxanthin form the macular pigment and protect the from the BLUE spectrum of light. </li></ul><ul><li>Multiple lines of evidence indicate that they are likely to protect against AMD </li></ul><ul><li>171 studies published since 2001 </li></ul><ul><li>Inverse correlation between serum carotenoid levels and risk of exudative AMD. </li></ul><ul><li>Human autopsies and Raman studies have shown ~30% less MP in those with AMD than without AMD. </li></ul>© Max Snodderly
  9. 9. Omega-3 from Fish Oil <ul><li>Multiple epidemiological studies have shown protection against AMD </li></ul><ul><li>46 studies published since 2001 </li></ul><ul><li>Omega-3 from fish oil is safe and well tolerated </li></ul><ul><li>Omega-3 from flax seed may promote the conversion to Wet AMD and also stimulates growth of prostate tumors </li></ul>
  10. 10. Omega-3 From Fish Oil May Prevent Wet AMD <ul><li>300 mg/day of Omega-3 (EPA/DHA) from fish oil reduces the risk of developing Wet AMD by 70% </li></ul><ul><ul><li>American Journal of Clinical Nutrition </li></ul></ul><ul><ul><li>August 8, 2008 </li></ul></ul>
  11. 11. PreserVision ® ICaps ® TOZAL ® Beta Carotene 28,640 IU Synthetic 28,640 IU Synthetic 18,640 IU Natural Vitamin A 10,000 IU Total Vitamin A 28,640 IU 28,640 IU 28,640 IU Vitamin C 452 mg 452 mg 452 mg Vitamin E 400 IU 400 IU 200 IU Zinc 69.6 mg 69.6 mg 69.6 mg Copper 1.6 mg 1.6 mg 1.6 mg Lutein 10 mg Zeaxanthin 500 mcg Taurine 400 mg EPA Omega 3 360 mg DHA Omega 3 240 mg Anthocyanidins 12.5 mg
  12. 12. TOZAL ® v. AREDS2 <ul><li>AREDS2 = OZAL </li></ul><ul><ul><li>TOZAL without Taurine </li></ul></ul><ul><li>“ The findings of the TOZAL study predict the results of the much larger AREDS2 study … will yield similar positive effects.” </li></ul><ul><ul><li>Jerome Sherman, OD, FAAO </li></ul></ul><ul><ul><ul><li>Distinguished Teaching Professor – SUNY/Optometry </li></ul></ul></ul>
  13. 13. Science based evidence for the use of supplements as a PREVENTIVE for AMD <ul><li>Our findings suggest that dietary omega-3 long-chain polyunsaturated fatty acid intake is associated with a decreased risk of progression from bilateral drusen to CGA. AREDS report 23 </li></ul><ul><li>Lutein and DHA may aid in prevention of age-related macular degeneration. The influence of supplemental lutein and docosahexaenoic acid on serum, lipoproteins, and macular pigmentation. Am J Clin Nutr </li></ul><ul><li>Foods high in omega-3 could reduce the risk of this debilitating eye disease by 38 percent. Omega-3 intake linked with lowered risk of age-related macular degeneration. Health News. 2008 Sep;14(9):6-7. </li></ul><ul><li>There is a biologically plausible rationale whereby macular pigment, which is entirely of dietary origin, may prevent or delay the onset, or ameliorate the clinical course, of ARM. The rationale and evidence base for a protective role of macular pigment in age-related maculopathy. Br J Ophthal Sep 08 </li></ul><ul><li>Macular Degeneration Partnership suggests vitamin supplementation for those who: </li></ul><ul><ul><li>are over age 50 </li></ul></ul><ul><ul><li>have a family history of AMD </li></ul></ul>
  14. 14. What type of patient can benefit from TOZAL ® Eye Health Formula <ul><li>AMD Sufferers </li></ul><ul><ul><li>TOZAL has been shown to stablize and/or improve vision in dry AMD </li></ul></ul><ul><ul><li>TOZAL may reduce the conversion to wet AMD by up to 70% </li></ul></ul><ul><li>Positive Family History Over 55 Years of Age </li></ul><ul><ul><li>TOZAL may reduce the risk of developing AMD by 43% - 70% </li></ul></ul>
  15. 15. The Art of Self-Defense TOZAL ® Eye Health Formula <ul><li>Glaucoma is more than just high intraocular pressure </li></ul><ul><ul><li>49 peer-reviewed studies </li></ul></ul><ul><ul><li>support antioxidants & O-3 </li></ul></ul><ul><ul><li>Oxidative Stress damages retinal ganglion cells </li></ul></ul><ul><ul><li>Vascular Regulation </li></ul></ul><ul><ul><ul><li>O-3 Improves Vascular Regulation </li></ul></ul></ul><ul><li>Antioxidants and Omega-3 Reduce the Dia Retinopathy </li></ul><ul><ul><li>Arch Ophthal, Sept 08 </li></ul></ul><ul><ul><ul><li>Kowlura, Chan, et. al </li></ul></ul></ul>
  16. 16. <ul><li>Introducing AmeriSciences </li></ul>
  17. 18. <ul><li> </li></ul>
  18. 19. <ul><li>Introducing AmeriSciences </li></ul>