A New Perspective on  Total Wellness Within the Medical Practice Anastazia Krneta  877-720-2982   [email_address] www.ownw...
<ul><li>AmeriSciences TOZAL Eye Health Formula: Successfully launched and establish consumer base since 2008 </li></ul><ul...
<ul><li>Leading cause of blindness in the US in those ages 55+ (affects more people than glaucoma and cataracts combined) ...
<ul><li>Standard of Care: Every patient with AMD or at risk for AMD should take an antioxidant-based nutritional supplemen...
<ul><li>B&L PreserVision 2 </li></ul><ul><ul><li>Available as of May 2010 </li></ul></ul><ul><ul><li>Removed b-carotene </...
<ul><li>Age-Related Visual Decline </li></ul><ul><li>Dry Eye </li></ul><ul><li>Visual Acuity  </li></ul><ul><li>Ocular Nut...
<ul><li>AREDS/TOZAL-inspired backbone </li></ul><ul><li>Lutein & Zeaxanthin (2000 mcg vs. 500 mcg) </li></ul><ul><li>Alpha...
<ul><li>Cangemi FE. TOZAL Study: An open case control study of an oral antioxidant and omega-3 supplement for dry AMD. BMC...
<ul><li>Richer et al. LAST Study: Double-masked, placebo-controlled, randomized trial of lutein and antioxidant supplement...
<ul><li>Majority of research on retina and AMD (TOZAL, AREDS2, CAREDS/WHI, etc) </li></ul><ul><ul><li>↑  intake of n3  =  ...
<ul><li>Singh & Jialal I. 2008:  </li></ul><ul><ul><li>Retinopathy, cataract formation, endothelial cell damage and vascul...
<ul><li>Parekkh et al (Arch Ophtal 2007) and Mascitelli et al (Ophthal 2010): </li></ul><ul><ul><li>Serum Vitamin D levels...
<ul><li>Nagaki et al (2002):  Eye strain in normal individuals </li></ul><ul><ul><li>46% reduction in eye strain and highe...
<ul><li>Vitamin E </li></ul><ul><ul><li>Many primary care doctors are advising their patients against taking high levels o...
<ul><li>Concerns about Zn levels </li></ul><ul><ul><li>High awareness that AREDS levels can lead to kidney toxicity  </li>...
<ul><li>Further product appeal through: </li></ul><ul><ul><li>Stand-alone formulation </li></ul></ul><ul><ul><li>Gelcap th...
<ul><li>Continuing to set the standard of care </li></ul><ul><li>Measurement of clinical outcomes </li></ul>THE FUTURE
THE FUTURE
Science-based nutrition   built on   Leadership, Faith and Vision For information how you can incorporate wellness in your...
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OS2 - Ocular Solution

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A New Perspective on Total Wellness Within the Medical Practice

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OS2 - Ocular Solution

  1. 1. A New Perspective on Total Wellness Within the Medical Practice Anastazia Krneta 877-720-2982 [email_address] www.ownwellness.com
  2. 2. <ul><li>AmeriSciences TOZAL Eye Health Formula: Successfully launched and establish consumer base since 2008 </li></ul><ul><li>Ever-present need to stay in the cutting edge </li></ul><ul><li>Fierce competition </li></ul><ul><ul><li>“ shotgun approach” (e.g. Guberman Health, Science Based Health) </li></ul></ul><ul><ul><li>“ single ingredient approach” (e.g. Nature Made, Nordic Naturals) </li></ul></ul><ul><ul><li>“ AREDS approach” (e.g. GNC, B&L) </li></ul></ul>AMERISCIENCES OCULAR NUTRITION
  3. 3. <ul><li>Leading cause of blindness in the US in those ages 55+ (affects more people than glaucoma and cataracts combined) </li></ul><ul><li>15 million+ Americans are affected by AMD </li></ul><ul><li>50 million+ Americans are at risk for AMD </li></ul><ul><li>35% of Americans over 75 have AMD </li></ul><ul><li>In the US alone, these numbers will increase by over 50% in less than 14 years – the global picture is similar </li></ul>AGE-RELATED MACULAR DEGENERATION
  4. 4. <ul><li>Standard of Care: Every patient with AMD or at risk for AMD should take an antioxidant-based nutritional supplement </li></ul><ul><li>Risk Factors </li></ul><ul><ul><li>Aging (55 + years of age) </li></ul></ul><ul><ul><li>Female Gender </li></ul></ul><ul><ul><li>Caucasians / Asians </li></ul></ul><ul><ul><li>Family History </li></ul></ul><ul><ul><li>Smoking </li></ul></ul><ul><ul><li>Cardiovascular Disease / Hypertension </li></ul></ul>AGE-RELATED MACULAR DEGENERATION
  5. 5. <ul><li>B&L PreserVision 2 </li></ul><ul><ul><li>Available as of May 2010 </li></ul></ul><ul><ul><li>Removed b-carotene </li></ul></ul><ul><ul><li>Add lutein/zeaxanthin, omega-3 </li></ul></ul><ul><li>AmeriSciences years ahead of the curve </li></ul>NEW PLAYERS IN THE MARKETPLACE
  6. 6. <ul><li>Age-Related Visual Decline </li></ul><ul><li>Dry Eye </li></ul><ul><li>Visual Acuity </li></ul><ul><li>Ocular Nutrition for the maintenance of health </li></ul><ul><ul><li>Diabetes Nutrition </li></ul></ul><ul><ul><li>Vascular Nutrition </li></ul></ul><ul><ul><li>Retinal & Mitochondrial Nutrition </li></ul></ul>NEW AND EMERGING SCIENCE: Beyond AREDS & TOZAL
  7. 7. <ul><li>AREDS/TOZAL-inspired backbone </li></ul><ul><li>Lutein & Zeaxanthin (2000 mcg vs. 500 mcg) </li></ul><ul><li>Alpha Lipoic acid (e.g. retinopathy, microvascular, retinitis, mitochondrial, etc) </li></ul><ul><li>Vitamin D </li></ul><ul><li>Dismissal of β-carotene and PVA carotenoids </li></ul><ul><li>Astaxanthin </li></ul><ul><li>Supportive role of polyphenolics </li></ul>KEY INGREDIENTS
  8. 8. <ul><li>Cangemi FE. TOZAL Study: An open case control study of an oral antioxidant and omega-3 supplement for dry AMD. BMC Ophthalmology 2007, 7:3 </li></ul>KEY INGREDIENTS: AREDS/TOZAL “ Treatment with this unique nutritional supplement increased VA above the expected baseline decrease in the majority of patients in this population with dry macular degeneration”
  9. 9. <ul><li>Richer et al. LAST Study: Double-masked, placebo-controlled, randomized trial of lutein and antioxidant supplementation in the intervention of atrophic age-related macular degeneration. Optometry 2004; 75(4):216-229 </li></ul>KEY INGREDIENTS: LUTEIN & ZEAXANTHIN “ This study demonstrates that lutein alone or combined with additional carotenoids and antioxidants/minerals (including zinc) significantly improved macular pigment optical density and glare recovery, improved near visual acuity, and significantly improved most measures of quality of vision (contrast sensitivity function), with L+A having a broader effect.”
  10. 10. <ul><li>Majority of research on retina and AMD (TOZAL, AREDS2, CAREDS/WHI, etc) </li></ul><ul><ul><li>↑ intake of n3 = ↑ visual acuity = ↓ incidence of AMD </li></ul></ul><ul><ul><li>DHA thought to be of superior importance </li></ul></ul><ul><li>Tear Function & Dry Eye </li></ul><ul><ul><li>Mass. Eye & Ear (Cakiner et al 2008): “Studies have also shown that omega-3 fatty acids may slow the progression of vision loss and reverse the signs of dry eye syndrome.” </li></ul></ul><ul><ul><li>Mount Sinai (Rosenberg & Asbell 2010): “All the studies preliminarily confirmed that there is a relationship between EFA supplementation and improvement in DED.” </li></ul></ul><ul><ul><li>EPA plays a more important role (resolvins are derived from EPA, increase tear volume, decrease inflammation) </li></ul></ul>KEY INGREDIENTS: OMEGA-3 FATTY ACIDS
  11. 11. <ul><li>Singh & Jialal I. 2008: </li></ul><ul><ul><li>Retinopathy, cataract formation, endothelial cell damage and vascular dysfunction appear to be mediated by ROS generation. </li></ul></ul><ul><ul><li>LA supplementation prevents ROS formation and can ward off against these complications. </li></ul></ul><ul><li>Lin et al. 2006: </li></ul><ul><ul><li>LA acid prevents microvascular damage, retinal mitochondrial overproduction of ROS, and may provide additional endothelial protection. </li></ul></ul>KEY INGREDIENTS: ALPHA LIPOIC ACID
  12. 12. <ul><li>Parekkh et al (Arch Ophtal 2007) and Mascitelli et al (Ophthal 2010): </li></ul><ul><ul><li>Serum Vitamin D levels and vitamin D intake were inversely associated with incidence of AMD, visual acuity </li></ul></ul><ul><ul><li>In many cases, supplementation quickly and effectively improved VA parameters </li></ul></ul><ul><li>Albert et al (UW Med School, 2007): </li></ul><ul><ul><li>Vitamin D supplementation reduced retinal angiogenesis </li></ul></ul>KEY INGREDIENTS: VITAMIN D
  13. 13. <ul><li>Nagaki et al (2002): Eye strain in normal individuals </li></ul><ul><ul><li>46% reduction in eye strain and higher accommodation amplitude in VDT workers </li></ul></ul><ul><ul><li>Visual acuity improvement: Depth perception (45%), Critical flicker fusion (CFF, 5%). </li></ul></ul><ul><li>Cort et al (2010): Elevated intraocular pressure </li></ul><ul><ul><li>The presented data confirm the role of oxidative injury in EIOP. This and other studies highlight the protective effect of astaxanthin in ocular hypertension </li></ul></ul>KEY INGREDIENTS: ASTAXANTHIN
  14. 14. <ul><li>Vitamin E </li></ul><ul><ul><li>Many primary care doctors are advising their patients against taking high levels of vitamin E (such as those found in AREDS-based fmlas) </li></ul></ul><ul><ul><li>Many patients taking an ocular nutrition supplement also take a multivitamin </li></ul></ul><ul><li>Free Lutein vs. Lutein Esters </li></ul><ul><ul><li>Science has failed to validate assumption that one is superior </li></ul></ul><ul><ul><li>Bioavailability/functionality/stability may be superior for esters </li></ul></ul><ul><ul><li>Best when taken with fatty snack or oil </li></ul></ul><ul><ul><li>Fish oil as “carrier” will increase bioavailability </li></ul></ul>OTHER CONSIDERATIONS
  15. 15. <ul><li>Concerns about Zn levels </li></ul><ul><ul><li>High awareness that AREDS levels can lead to kidney toxicity </li></ul></ul><ul><ul><li>AREDS / AREDS-2 used inorganic salts </li></ul></ul><ul><ul><li>AREDS: potency not guaranteed </li></ul></ul><ul><ul><li>Zn oxide, Zn sulfate not bioavailable -> high doses needed </li></ul></ul><ul><ul><li>Zn chelates can achieve same plasma concentrations with lower doses </li></ul></ul>OTHER CONSIDERATIONS
  16. 16. <ul><li>Further product appeal through: </li></ul><ul><ul><li>Stand-alone formulation </li></ul></ul><ul><ul><li>Gelcap that incorporates omega-3 fatty acids and antioxidant formula </li></ul></ul><ul><li>Physician grassroots campaign </li></ul><ul><li>Patent protection of IP </li></ul>INNOVATION
  17. 17. <ul><li>Continuing to set the standard of care </li></ul><ul><li>Measurement of clinical outcomes </li></ul>THE FUTURE
  18. 18. THE FUTURE
  19. 19. Science-based nutrition built on Leadership, Faith and Vision For information how you can incorporate wellness in your practice contact Anastazia Krneta at 877-720-2982 or [email_address] www.ownwellness.com

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