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Ap bio ch 3 Functional Groups & Macromolecules


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Ap bio ch 3 Functional Groups & Macromolecules

  1. 1. The Molecules of Cells… dun dun dahhhhh – ch 3Organic chem -Carbon – most versatile building block – why?Tetravalence –Where does the C in your body come from?
  2. 2. Valences of common atoms in orgs What is the bonding capacity of H? What is the bonding capacity of O? What is the bonding capacity of N? What is the bonding capacity of C?
  3. 3. Which of these would be improperly bonded?
  4. 4. Variation in C skeletons contributes to diversity of organic moleculesStraight, branched, closed rings, some have double bonds, triple
  5. 5. Isomers• molecules w/ same molecular formula (same number and kinds of atoms) but diff atom arrangements (which atoms are attached to which and how) Classes of isomers: structural, geometric, enantiomers
  6. 6. Geometric isomers = share same covalent partnerships, butdiffer in their spatial arrangements.• Result from fact that double bonds will not allow the atomsthey join to rotate freely about the axis of the bonds.• Subtle differences affects biological activity.
  7. 7. • Enantiomers = mirror images of each other.• Can occur when 4 diff atoms or groups of atoms are bonded to the same carbon (asymmetric carbon).• 2 diff spatial arrangements of the four groups around the asymmetric carbon. These arrangements are mirror images.• Usually one form is biologically active and its mirror image is not.
  8. 8. How many asymmetric carbons are present?
  9. 9. Functional Groups• contribute to molecular diversity of life• frequently bonded to carbon skeleton of organic molecules.• Have specific chemical and physical properties.• Are the regions of organic molecules which are commonly chemically reactive.• Behave consistently from one organic molecule to another.• Depending upon their number and arrangement, determine unique chemical properties of organic molecules in which they occur.
  10. 10. Hydroxyl- OH• polar group• Conveys water solubility• Organic compounds with hydroxyl groups are called alcohols.
  11. 11. Carbonyl Group-C=O• polar group• Conveys water solubility.• found in sugars.• at the end of skeleton called aldehyde.• at the middle of skeleton called ketone
  12. 12. Carboxyl Group• polar group• Conveys water solubility• Since it donates protons, has acidic properties.• Compounds w/ this group are called carboxylic acids.
  13. 13. Amino Group• polar group• Conveys water solubility• Acts as weak base. The unshared pair of electrons on the nitrogen can accept a proton, giving it a +1 charge.• Organic compounds w/ this group are called amines.
  14. 14. Sulfhydryl Group• Help stabilize the structure of proteins.• Organic compounds with this functional group are called thiols. What other functional groups do you see in this molecule? Could this molecule have an enantiomer isomer? How do you know?
  15. 15. Phosphate Group• Loss of two protons leaves phosphate group w/ a - charge.• Has acid properties since it loses protons.• Polar group• Conveys water solubility• Important in cellular energy storage & transfer
  16. 16. Methyl Group• Non polar• Conveys hydrophobic properties
  17. 17. Macromolecules, baby!CarbsLipidsProteinsNucleic acids
  18. 18. Some basicsPolymer – long molecule consisting of many similar or identical building blocks linked by covalent bondsMonomer -
  19. 19. How do the bonds b/t monomers form?Condensation rx or dehydration synthesis – removal of water from monomersFacilitated by enzymes – speed up the rx
  20. 20. How do the bonds b/t monomers break?Hydrolysis – bonds broken by addition of waterHydro = waterLysis = breakEx: digestionEnzymes facilitate
  21. 21. Diversity of macromolecules26 letters make many words40-50 monomers make many macromoleculesKey is in arrangement of monomersTac Act Cat
  22. 22. Carbohydrates• Function – fuel & building mat.• Sugars & their polymers• simplest are monosaccharides or simple sugars.• Disaccharides (double sugars) consist of 2 monosaccharides joined by condensation reaction.• Polysaccharides - polymers of many monosaccharides.
  23. 23. monosaccharides• some multiple of the unit CH2O.• Ex: glucose = C6H12O6.• Funcitonal groups: carbonyl group (>C=O) and multiple hydroxyl groups (—OH).• names end in -ose.•
  24. 24. Diversity of monosaccharides• classified by # of carbon atoms in skeleton (3-7)• Some are enantiomers of each other - spatial arrangement of their parts around asymmetric C atoms. Structural isomers enantiomers
  25. 25. Monosaccharides cont…• most form rings in aqueous solutions.• major nutrients for cellular work.
  26. 26. Disaccharides• glycosidic linkage to form a disaccharide via dehydration.• Maltose - joining 2 glucose• Sucros- joining glucose & fructose.• Lactose - joining glucose & galactose.
  27. 27. Polysaccharides - storage• Function in storage & structural roles.• 100s – 1000s of monosaccharides joined• Starch - plant storage polysac composed entirely of glucose monomers.• Plants store surplus glucose as starch granules within plastids, including chloroplasts & withdraw as needed for E or C.• Glycogen – animal storage polysac. Store 1 day supply in liver & muscles
  28. 28. Polysaccharides - structural• Cellulose – plant structural polysac - major component of cell walls – most abundant organic compound on Earth. – Like starch, cellulose is polymer of glucose. However, the glycosidic linkages in these two polymers differ. – Digestion... Symbiotic orgs• Chitin – animal structural polysac - found in the exoskeletons of arthropods – also provides structural support for cell walls of fungi.
  29. 29. Lipids• Consist mostly of hydrocarbon• Little – no affinity for H2O (water insoluble)• Not polymers• 3 families – Fats – Phospholipids – Steroids
  30. 30. Fats• Glycerol & & fatty acid• Dehydration synthesis• Linkage – ester• Vary in length & the # & location of double bonds• Functions: – E storage – Cushions organs – Insulates body
  31. 31. 2 main types of fats1. Saturated – saturated w/ H; no double bonds – Animal fats – Solid @ room temp… why? – Contribute to arteriosclerosis Yum !
  32. 32. 2 main types of fats2. Unsaturated – not saturated w/ H; has double bonds Creates kink in shape @ double bond Liquid @ room temp Plants & fish Peanut butter? Why solid?
  33. 33. Phospholipids• 1 glycerol• 2 fatty acids• 1 phosphate group
  34. 34. Phospholipids• Amphipathic• Major component of cell membranes• Structure determines function
  35. 35. Steroids• C skeleton consisting of 4 interconnected rings.• Vary based on functional groups• Cholesterol – imp. In membranes of animal cells – Most other steroids made from it
  36. 36. Proteins!• large• funcitons: – Structure (silk) – Storage (casein) – Movement (actin & myosin) – Defense (antibodies) – Regulation of metabolism (enzymes) – Transport (hemoglobin) – Communication (hormones) – receptor proteins
  37. 37. basics• Monomer – amino acids (20 diff) – Vary based on R groups – Structure of aa – Linkage – peptide bond – Backbone – Aka polypeptide
  38. 38. Condensation reaction or dehydration synthesis
  39. 39. Conformation = 3 D shape of a protein moleculeShape determines functionDNA codes for the type of aa & what order they’re bonded inSo…DNA codes for which proteins you make & which proteins you make determines your physical characteristics
  40. 40. Proteins are so complex that we describe theirstructure on 4 levels 1. Primary structure • the seq of aa • Det by DNA • Sanger, insulin
  41. 41. Notice primary structure & backbone
  42. 42. Proteins are so complexthat we describe their structure on 4 levels2) Secondary structure• Pattern of folds & coils that result from the H-bonding at regular intervals along the polypeptide backbone.• 2 types: alpha helix & pleated sheet
  43. 43. Proteins are so complex that we describe their structure on 4 levels3) Tertiary structure• Irregular contortions that result from bonding b/t R groups of the aa• Types of bonds that can occur b/t R groups: – H-bonds, disulfide bridges, ionic, hydrophobic interactions
  44. 44. Proteins are so complex that we describe their structure on 4 levels4) Quaternary structure• Only those composed of 2 or more polypeptide chains• Overall structure that results from the aggregation of polypeptide chains
  45. 45. Emergent property?Specific function of a protein arises from the architecture of the molecule
  46. 46. Denaturation?• Loss of conformation of a protein• Causes? High temps, change in salt concentration, change in pH
  47. 47. Review of levels
  48. 48. Nucleic Acids•Deoxyribonucleic acid (DNA) & RNA•Double helix•Watson and Crick—1953•Made of smaller molecules callednucleotides bonded together
  49. 49. Relationshipbetween DNA&chromosomes?Chromosomesare made ofDNA!
  50. 50. Monomers are nucleotides5 Different ones• Deoxyribose: sugar molecule• Phospahte group: a phosphorus atom surrounded by oxygen• Nitrogen containing base: molecule containing nitrogen adenine (A) guanine (G) cytosine (C) thymine (T)
  51. 51. Dehydration synthesis & then H-bonds b/t N bases
  52. 52. Complementary Base Pairing• Cytosine - Guanine• Adenine - Thymine• Connected by H-bonds• Allows DNA to make exact copies of itself
  54. 54. Complementary Base Pairs• TTACGGCAT base pair would be????
  55. 55. DNA & RNA
  56. 56. DNA & RNA Compared DNA RNASugar deoxyribose riboseStrands double singleBases A,G,C,T A,G,C,U (uracil)
  57. 57. Notice thedifference between the 2 sugars?Sugar in DNASugar in RNA
  58. 58. How is DNA the code for life?• Gene – portion of DNA that codes for the making of polypeptide (protein)• What makes you unique is all the particular proteins you make.