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Eicosanoids
• Def:20 C compounds
derived from
Arachidonic acid
classification
Eicosanoids
Prostanoids Leukotrienes Lipoxins
(Lipoxygenase pathway)
Prostglandins Thromboxanes
(cyclooxygenase pathway)
• Chemistry :
- Prostaglandins – first
isolated from prostate
tissue & hence the name
- present in all tissues
- a five C ring
Naming
1. Capital letter suffix (eg. PGE)
denotes substituent group
attached to ring
2. PGI is called prostacyclin since it
contains additional ring formed
by cyclization of side chain
3. Number denoted by a subscript
after suffix indicates no. of
double bonds on side chain
(PGE2)
4. PGG & PGH are intermediates
during synthesis

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eicosanoids.ppt