Krebs-U.C.S.-2010

662 views

Published on

Published in: Technology, Business
0 Comments
1 Like
Statistics
Notes
  • Be the first to comment

No Downloads
Views
Total views
662
On SlideShare
0
From Embeds
0
Number of Embeds
10
Actions
Shares
0
Downloads
36
Comments
0
Likes
1
Embeds 0
No embeds

No notes for slide

Krebs-U.C.S.-2010

  1. 1. Thanh Uyen Pham Snousha Glaude Chelsea Farber Ap Biology
  2. 2. Other names: Citric acid cycle & tricarboxylic acid cycle  Discovered by Hans Adolf Krebs in the 1930s. Krebs Cycle completes the oxidation of organic molecules (to breakdown the pyruvic acid to CO2).  Occurs within the mitochrondrion Requires energy (aerobic phase) Two pyruvate were broken down from one glucose during glycolysis, thus the Krebs cycle will occur twice for every glucose.
  3. 3. Oxidation: the process of losing electrons from a chemical element or compound Decarboxylation: the process of removing a carboxyl group (CO2) from a chemical compound (usually replacing it with hydrogen)
  4. 4. Before the cycle begins, pyruvic acid obtained from glycolysis is converted into an acetyl Coenzyme A (acetyl CoA)  This occurrence produced a CO2 and formed an NADH molecule.
  5. 5. 1st : Acetyl CoA enters the mitochrondria, its 2-carbon acetyl is transferred to a 4-carbon compound oxaloacetate, releasing the CoA carrier. This process produced a 6-carbon compound citrate 2nd : The citrate is rearranged to form its isomeric form, isocitrate, by the removal of an H2O and addition of an H2O
  6. 6. 3rd : The compound decarboxylated a CO2, becoming oxidized to form a 5-carbon compound alpha-ketoglutarate The step decarboxylated the carboxyl group (CO2) and hydrogen is remove and transfer to NAD+ to formed NADH 4th : The compound is decarboxylated and oxidized, forming a 4- carbon compound succinyl-CoA (with the attachment of a CoA carrier) This step resulted in the release of a CO2 and formation an NADH
  7. 7. 5th : CoA carrier is release by a phosphate group, turning the compound from succinyl-CoA to succinate --The phosphate is transferred to GDP to make GTP, which is converted to ADP and then finally to ATP 6th : 2 Hydrogen are released, transferred to FAD, forming FADH2, the 4-carbon succinate is oxidized to form a fumarate.
  8. 8. 7th : Water is added to fumarate to form malate 8th : The malate is oxidized to form the 4-carbon oxaloacetate --the step formed another NADH
  9. 9.  Animation from McGraw-Hill
  10. 10. 1 ATP 3 NADH 1 FADH2 2 CO2
  11. 11. THE END

×