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Analysis of polyps by using R

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Analysis of polyps by using R

  1. 1. Analysis of Polypsby using R20106102 강민규20106120 김형섭20106122 류승우
  2. 2. Contents• About Polyps ▫ Colonial Polyps(대장 용종)이란?• Script Analysis ▫ 통계적 결과 해석• 생화학적 기전• 결과 및 결론
  3. 3. About Polyps
  4. 4. About Polyps
  5. 5. About Polyps •비스테로이드성 항염증제 (NSAIDs Non-Steroidal Anti Imflammatory Drugs) •대장용종 예방에 효과적 •대표적으로 아스피린 (Aspirin)이 NSAIDs에 속한 다
  6. 6. Script Analysis• library("HSAUR2")• ## HSAUR2 패키지 library에 등록,polyps자료 탐색• summary(polyps)• ## polyps 자료 요약• number treat age• Min. : 1.00 placebo:11 Min. :13.00• 1st Qu.: 3.75 drug : 9 1st Qu.:19.75• Median :21.00 Median :22.50• Mean :24.05 Mean :25.00• 3rd Qu.:41.00 3rd Qu.:27.75• Max. :63.00 Max. :50.00• aggregate(polyps[,"number"],list(polyps$treat),summary)• ## polyps의 수와 대조, 조작군에 대한 summary• Group.1 x.Min. x.1st Qu. x.Median x.Mean x.3rd Qu. x.Max.• 1 placebo 7.000 21.500 40.000 35.640 48.000 63.000• 2 drug 1.000 2.000 3.000 9.889 17.000 33.000
  7. 7. • aggregate(polyps[,"age"],list(polyps$treat),summary)• ## polyps 환자의 나이와 대조,조작군에 대한 summary• Group.1 x.Min. x.1st Qu. x.Median x.Mean x.3rd Qu. x.Max.• 1 placebo 13.00 19.50 22.00 26.27 32.00 50.00• 2 drug 16.00 22.00 23.00 23.44 23.00 42.00• jpeg("polyps.jpg",width=720,height=400)• ## jpeg device 활성• layout(matrix(1:2,ncol=2))• ## 2칸짜리 layout 형성• plot(number~treat, data=polyps)• ## polyps 수와 treat사이의 관계 boxplot• plot(age~treat, data=polyps)• ## polyps 환자의 age와 treat 사이의 관계 boxplot• Dev.off()• ## device 비활성• tapply(polyps$age, polyps$treat,stem)• ## 줄기, 잎 그림으로 비교
  8. 8. Boxplot 출력결과
  9. 9. • The decimal point is 1 digit(s) to the right of the |• 1 | 389• 2 | 0227• 3 | 044• 4|• 5|0• The decimal point is 1 digit(s) to the right of the |• 1 | 67• 2 | 223333• 3|• 4|2• $placebo• NULL• $drug• NULL• polyps_glm.1<-glm(number~treat+age, data=polyps, family=poisson())• ## polyps_glm.1 에 glm함수(poisson) objecting• summary(polyps_glm.1)• ## glm, poisson 에러 모형으로 적합test
  10. 10. • Call:• glm(formula = number ~ treat + age, family = poisson(), data = polyps)• Deviance Residuals:• Min 1Q Median 3Q Max• -4.2212 -3.0536 -0.1802 1.4459 5.8301• Coefficients:• Estimate Std. Error z value Pr(>|z|)• (Intercept) 4.529024 0.146872 30.84 < 2e-16 ***• treatdrug -1.359083 0.117643 -11.55 < 2e-16 ***• age -0.038830 0.005955 -6.52 7.02e-11 ***• ---• Signif. codes: 0 ‘***’ 0.001 ‘**’ 0.01 ‘*’ 0.05 ‘.’ 0.1 ‘ ’ 1• (Dispersion parameter for poisson family taken to be 1)• Null deviance: 378.66 on 19 degrees of freedom• Residual deviance: 179.54 on 17 degrees of freedom• AIC: 273.88• Number of Fisher Scoring iterations: 5
  11. 11. • polyps_glm.2<-glm(number~treat+age, data=polyps, family=quasipoisson())• ## polyps_glm.2 에 glm 함수(quasipoisson) objecting• summary(polyps_glm.2)• ## glm, quasi-poisson 에러 모형으로 적합• Call:• glm(formula = number ~ treat + age, family = quasipoisson(),• data = polyps)• Deviance Residuals:• Min 1Q Median 3Q Max• -4.2212 -3.0536 -0.1802 1.4459 5.8301• Coefficients:• Estimate Std. Error t value Pr(>|t|)• (Intercept) 4.52902 0.48106 9.415 3.72e-08 ***• treatdrug -1.35908 0.38533 -3.527 0.00259 **• age -0.03883 0.01951 -1.991 0.06284 .• ---• Signif. codes: 0 ‘***’ 0.001 ‘**’ 0.01 ‘*’ 0.05 ‘.’ 0.1 ‘ ’ 1• (Dispersion parameter for quasipoisson family taken to be 10.72805)• Null deviance: 378.66 on 19 degrees of freedom• Residual deviance: 179.54 on 17 degrees of freedom• AIC: NA• Number of Fisher Scoring iterations: 5
  12. 12. 작용 기전
  13. 13. • Eicosanoids are synthesized from arachidonic acid, which is formed from phospholipids.• Arachidonic acid is converted to prostaglandin H2, catalyzed by cyclooxygenase.• This enzyme is the target of aspirin and other nonsteroidal anti-inflammatory drugs (NSAIDs).
  14. 14. • Aspirin and NSAIDs have also been found to reduce the frequency of colon cancer, apparently by inhibiting synthesis of prostaglandins that stimulate cell proliferation• Cox-1, cox-2 와 polyps, GI tract , asthma• Vioxx, celebrex 의 항암작용• Polyps와 NSAID의 실효성
  15. 15. 결과 정리 및 요약• R을 이용한 통계자료 분석 결과 ▫ Drug(NSAIDs)가 placebo와는 다르게 유의한 효과가 있다 ▫ Age는 treatment에 아무런 연관이 없다 ▫ Poisson과 quasi-poisson model의 차이는 polyps 발생 숫자의 overdispersion 에 의한 것이다• 생화학적 사실에 근거한 분석 결과 ▫ Prostaglandin 은 cell proliferation 을 activation 시켜 polyps, 또는 cancer를 발생시킨다 ▫ NSAIDs는 archidonic acid로부터 prostaglandin 을 유도하는 효소; Cyclooxigenase(COX) 를 저해한다
  16. 16. 감사합니다 !

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