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Disseminated intravascular coagulation

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disseminated intravascular coagulation

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Disseminated intravascular coagulation

  1. 1. BV Injury Platelet Activation Plt-Fusion Blood Vessel Constriction Coagulation Activation Stable Hemostatic Plug Thromibn, Fibrin Reduced Blood flow Tissue Factor Primary hemostatic plug Neural
  2. 2. Fibrinogen Fibrin Mononer Fibrin Polymer Cross Linked Fibrin Thrombin F-XIIIa
  3. 3.  Realease of tissue factor  Widespread endothelial injury
  4. 4. Activation of coagulation cascade Widespread micro thrombi Consumption coagulopathy Activation of fibrinolysis Bleeding
  5. 5.  Brain>heart>lungs>kidney>adrenals>spleen  Disseminated > localised  Endocrine adrenals pituitary
  6. 6.  Platelet count ?  Coagulation factors ?  Fibrinogen level ?  PTT ?  PT ?  Thrombin time ?  Fibrin degradation products ?  Plasmin ?  Microangipathic HA picture
  7. 7. BT Plt PT PTT Vascular Dis -  - - - PLT Disorder -  -  - - Factor 8/9 *Congenital - - -  Vit K / Liver *Acquired - -  - Combined (DIC)   - 

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