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www.rtog.org 1 WELCOME

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www.rtog.org 1 WELCOME

  1. 1. www.rtog.org 1 WELCOMEWELCOME To The Semi-AnnualTo The Semi-Annual RTOGRTOG RA OrientationRA Orientation Tampa FloridaTampa Florida February 1February 1stst , 2007, 2007
  2. 2. www.rtog.org 2  Established in 1968  Over 250 facilities participate in RTOG trials United StatesUnited States CanadaCanada FranceFrance IsraelIsrael AustraliaAustralia  NCI Funding and Corporate Support RTOG BACKGROUNDRTOG BACKGROUND
  3. 3. www.rtog.org 3  Opened 300 ProtocolsOpened 300 Protocols  Accrued 60,000 patients to cooperativeAccrued 60,000 patients to cooperative group studiesgroup studies  Published more than 700 papersPublished more than 700 papers  Maintains a roster of 40 active studiesMaintains a roster of 40 active studies devoted to the group’s primary disease sitesdevoted to the group’s primary disease sites
  4. 4. www.rtog.org 4 RTOG PRIMARY DISEASE SITESRTOG PRIMARY DISEASE SITES  CNSCNS  Head & NeckHead & Neck  LungLung  BreastBreast
  5. 5. www.rtog.org 5 RTOG PRIMARY DISEASE SITESRTOG PRIMARY DISEASE SITES  GYNGYN  GenitourinaryGenitourinary BladderBladder ProstateProstate  GastrointestinalGastrointestinal EsophagusEsophagus RectumRectum Anal CanalAnal Canal StomachStomach
  6. 6. www.rtog.org 6 MISSIONMISSION  Improve survival outcome and quality of life of adults withImprove survival outcome and quality of life of adults with cancercancer  Evaluate new forms of radiotherapy delivery.Evaluate new forms of radiotherapy delivery. [brachytherapy, 3-dimensional conformal radiotherapy,[brachytherapy, 3-dimensional conformal radiotherapy, intensity modulated radiotherapy (IMRT ]intensity modulated radiotherapy (IMRT ]  Test new systemic therapies in conjunction with RTTest new systemic therapies in conjunction with RT [chemotherapy, hormonal treatment, biologic agents and[chemotherapy, hormonal treatment, biologic agents and new classes of cytostatic, cytotoxic and targeted therapies]new classes of cytostatic, cytotoxic and targeted therapies]  Employ translational research strategies to identify patientEmploy translational research strategies to identify patient subgroups at risk for failure with existing treatments andsubgroups at risk for failure with existing treatments and identify new approaches for these patientsidentify new approaches for these patients
  7. 7. www.rtog.org 7 RTOG STAFFRTOG STAFF  Over 60 RTOG staff membersOver 60 RTOG staff members AdministrativeAdministrative Research AssociatesResearch Associates StatisticiansStatisticians Quality AssuranceQuality Assurance Protocol DevelopmentProtocol Development
  8. 8. www.rtog.org 8 RECENTRECENT ACCOMPLISHMENTSACCOMPLISHMENTS
  9. 9. www.rtog.org 9 CERVIX CANCERCERVIX CANCER • RTOG demonstratedRTOG demonstrated that combiningthat combining chemotherapy withchemotherapy with pelvic radiationpelvic radiation improves the 5 yearimproves the 5 year survival rate for womensurvival rate for women with locally advancedwith locally advanced cervix cancer fromcervix cancer from 58% to 73%.58% to 73%.
  10. 10. www.rtog.org 10 LUNG CANCERLUNG CANCER • RTOG FOUND THATRTOG FOUND THAT HEALTHIER PATIENTS WITHHEALTHIER PATIENTS WITH INOPERABLE NON-SMALL-INOPERABLE NON-SMALL- CELL LUNG CANCER HADCELL LUNG CANCER HAD BETTER RESULTS IF THEYBETTER RESULTS IF THEY RECEIVEDRECEIVED CHEMOTHERAPYCHEMOTHERAPY DURINGDURING RADIOTHERAPY RATHERRADIOTHERAPY RATHER THAN PRIOR TOTHAN PRIOR TO RADIOTHERAPY.RADIOTHERAPY.
  11. 11. www.rtog.org 11 HEAD AND NECKHEAD AND NECK • RTOG demonstrated theRTOG demonstrated the superiority of concomitantsuperiority of concomitant boost radiotherapy andboost radiotherapy and hyperfractionated radiotherapyhyperfractionated radiotherapy for locally advanced squamous-for locally advanced squamous- cell carcinoma.cell carcinoma. • RTOG demonstrated thatRTOG demonstrated that patients who receivedpatients who received chemotherapy together withchemotherapy together with their radiotherapy after surgerytheir radiotherapy after surgery were far less likely to have awere far less likely to have a recurrence of their cancer.recurrence of their cancer.
  12. 12. www.rtog.org 12 BRAINBRAIN • RTOG improved survivalRTOG improved survival more thanmore than 33%33% for patients with a singlefor patients with a single brain metastasis by usingbrain metastasis by using whole brain radiotherapywhole brain radiotherapy followed by stereotacticfollowed by stereotactic radiosurgery boost insteadradiosurgery boost instead of whole brain treatmentof whole brain treatment alonealone..
  13. 13. www.rtog.org 13 CNS LYMPHOMACNS LYMPHOMA • RTOG improved the medianRTOG improved the median survival for patients withsurvival for patients with non-AIDS-related primarynon-AIDS-related primary CNS lymphoma fromCNS lymphoma from 11.611.6 monthsmonths toto 30.430.4 monthsmonths by giving high doseby giving high dose chemotherapy for 10 weekschemotherapy for 10 weeks prior to RT.prior to RT.
  14. 14. www.rtog.org 14 THANK YOU !THANK YOU !

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