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  • WELCOME…..
    THIS IS YOUR CHANCE TO LEARN RTOG PROCEDURES IN AN INFORMAL SETTING.
    PLEASE FEEL FREE TO ASK QUESTIONS AT ANY TIME DURING THE NEXT TWO DAYS
  • RTOG IS NEARLY 40 YEARS OLD
    WE ACTIVELY SEEK CORPORATE SUPPORT
  • MISSION
    IMPROVE SURVIVAL AND QOL ADULTS W CANCER
    NEW RT DELIVERY
    NEW SYSTEMIC W RT
    MORE RECENTLY TRANSLATIONAL
    SUBGROUPS RISK FOR FAILURE
    IDENTIFY NEW APPROACHES FOR THEM
  • COMBINING CHEMO W RT
    IN CERVICAL CA IMPROVED
    5 YR SURVIVAL RATE FROM
    58%-73%
  • PTS WITH INOPERABLE LUNG CA WHO RECEIVED CHEMO DURING RT
    RATHER THAN PRIOR TO RT
    HAD BETTER RESULTS
  • PTS WHO RECEIVED CHEMO W RT
    AFTER SURGERY
    LESS LIKELY TO RECUR
    IN HEAD AND NECK CANCERS
  • THE ADDITION OF A BOOST TO WHOLE BRAIN RT IN PTS WITH ONE BRAIN MET HAD THEIR SURVIVAL IMPROVED BY MORE THAN 33%
  • PTS W LYMPHOMA SAW THEIR SURVIVAL RATE INCREASE FROM 11.6MO TO 30.4 MOS WHEN TREATED W HIGH DOSE CHEMO PRIOR TO RT
  • THE DATA THAT YOU GATHER MAKES THIS ALL POSSIBLE
    SO WE THANK YOU FOR YOUR HARD WORK
  • Slide 1

    1. 1. www.rtog.org 1 WELCOMEWELCOME RTOGRTOG RA OrientationRA Orientation PhiladelphiaPhiladelphia
    2. 2. www.rtog.org 2  Established in 1968  Several International facilities participate in RTOG trials United StatesUnited States KoreaKorea CanadaCanada Saudi ArabiaSaudi Arabia FranceFrance IrelandIreland IsraelIsrael AustraliaAustralia  NCI Funding and Corporate Support RTOG BACKGROUNDRTOG BACKGROUND
    3. 3. www.rtog.org 3 RTOG BACKGROUNDRTOG BACKGROUND  Opened >400 ProtocolsOpened >400 Protocols  Enrolled 65,000 patients to its studiesEnrolled 65,000 patients to its studies  Published more than 700 papersPublished more than 700 papers  Maintains a roster of 40 active studiesMaintains a roster of 40 active studies devoted to the group’s primary disease sitesdevoted to the group’s primary disease sites
    4. 4. www.rtog.org 4 RTOG PRIMARY DISEASE SITESRTOG PRIMARY DISEASE SITES  BRAINBRAIN  Head & NeckHead & Neck  LungLung  BreastBreast
    5. 5. www.rtog.org 5 RTOG PRIMARY DISEASE SITESRTOG PRIMARY DISEASE SITES  GYNGYN  GenitourinaryGenitourinary BladderBladder ProstateProstate  GastrointestinalGastrointestinal EsophagusEsophagus RectumRectum Anal CanalAnal Canal StomachStomach PancreasPancreas  SarcomaSarcoma
    6. 6. www.rtog.org 6 MISSIONMISSION  Improve survival outcome and quality of life of adults withImprove survival outcome and quality of life of adults with cancercancer  Evaluate new forms of radiotherapy delivery.Evaluate new forms of radiotherapy delivery. (brachytherapy, 3-dimensional conformal radiotherapy,(brachytherapy, 3-dimensional conformal radiotherapy, intensity modulated radiotherapy) (IMRT)intensity modulated radiotherapy) (IMRT)  Test new systemic therapies in conjunction with RTTest new systemic therapies in conjunction with RT (chemotherapy, hormonal treatment, biologic agents and(chemotherapy, hormonal treatment, biologic agents and new classes of cytostatic, cytotoxic and targeted therapies)new classes of cytostatic, cytotoxic and targeted therapies)  Employ translational research strategies to identify patientEmploy translational research strategies to identify patient subgroups at risk for failure with existing treatments andsubgroups at risk for failure with existing treatments and identify new approaches for these patientsidentify new approaches for these patients
    7. 7. www.rtog.org 7 RTOG STAFFRTOG STAFF  Over 80 RTOG staff membersOver 80 RTOG staff members AdministrativeAdministrative Research AssociatesResearch Associates StatisticiansStatisticians Quality AssuranceQuality Assurance Protocol DevelopmentProtocol Development
    8. 8. www.rtog.org 8 ACCOMPLISHMENTSACCOMPLISHMENTS
    9. 9. www.rtog.org 9 CERVIX CANCERCERVIX CANCER RTOG 9001RTOG 9001 • RTOG demonstratedRTOG demonstrated that combiningthat combining chemotherapy withchemotherapy with pelvic radiationpelvic radiation improves the 5 yearimproves the 5 year survival rate for womensurvival rate for women with locally advancedwith locally advanced cervix cancer fromcervix cancer from 58% to 73%.58% to 73%.
    10. 10. www.rtog.org 10 LUNG CANCERLUNG CANCER RTOG 9410RTOG 9410 • RTOG FOUND THATRTOG FOUND THAT HEALTHIER PATIENTS WITHHEALTHIER PATIENTS WITH INOPERABLE NON-SMALL-INOPERABLE NON-SMALL- CELL LUNG CANCER HADCELL LUNG CANCER HAD BETTER RESULTS IF THEYBETTER RESULTS IF THEY RECEIVEDRECEIVED CHEMOTHERAPY DURINGCHEMOTHERAPY DURING RADIOTHERAPY RATHERRADIOTHERAPY RATHER THAN PRIOR TOTHAN PRIOR TO RADIOTHERAPY.RADIOTHERAPY.
    11. 11. www.rtog.org 11 HEAD AND NECK CANCERSHEAD AND NECK CANCERS RTOG 9003RTOG 9003 • RTOG demonstrated theRTOG demonstrated the superiority of concomitantsuperiority of concomitant boost radiotherapy andboost radiotherapy and hyperfractionated radiotherapyhyperfractionated radiotherapy for locally advanced squamous-for locally advanced squamous- cell carcinoma.cell carcinoma. • RTOG demonstrated thatRTOG demonstrated that patients who receivedpatients who received chemotherapy together withchemotherapy together with their radiotherapy after surgerytheir radiotherapy after surgery were far less likely to have awere far less likely to have a recurrence of their cancer.recurrence of their cancer.
    12. 12. www.rtog.org 12 BRAIN CANCERBRAIN CANCER RTOG 9508RTOG 9508 • RTOG improved survivalRTOG improved survival more thanmore than 33%33% for patients with a singlefor patients with a single brain metastasis by usingbrain metastasis by using whole brain radiotherapywhole brain radiotherapy followed by stereotacticfollowed by stereotactic radiosurgery boost insteadradiosurgery boost instead of whole brain treatmentof whole brain treatment alonealone..
    13. 13. www.rtog.org 13 CNS LYMPHOMACNS LYMPHOMA RTOG 9310RTOG 9310 • RTOG improved the medianRTOG improved the median survival for patients withsurvival for patients with non-AIDS-related primarynon-AIDS-related primary CNS lymphoma fromCNS lymphoma from 11.611.6 monthsmonths toto 30.430.4 monthsmonths by giving high doseby giving high dose chemotherapy for 10 weekschemotherapy for 10 weeks prior to RT.prior to RT.
    14. 14. www.rtog.org 14 PROSTATE CANCERPROSTATE CANCER RTOG 8531RTOG 8531 • RTOG found that men who continued on hormonal therapy for at least five years after their treatment for locally advanced prostate cancer, lived longer than men who discontinued the hormones earlier than the five year time point.
    15. 15. www.rtog.org 15 THANK YOU !THANK YOU !

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