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Experimental* therapies using stem-cells applied to SCI
[Spinal Cord Injury].
Date of report: October 19, 2006
Written by:...
A. ADULT STEM-CELLS
1) Netherlands/Turkey-Azerbijan- Cells4Health.
• Who? Cornelis Kleinbloesem : CEO of Cells4Health with...
• Results: no transparency. ACT does not reply when asked about patients’ results.
• Website: www.stem-cells.com
4) Moscou...
• Status: 12 patients had the procedure at time of report?
8) Buenos Aires, Argentina- Dr. Gustavo Moviglia et al
• Cells ...
15) Lisbon, Portugal – Dr Lima
• Cells: Adult OEC from patient himself. Those are not, technically speaking, stem-
cells, ...
• Status: ongoing at the time of this report. Hundreds of patients have been treated, but
results are not followed up [exc...
• Status: ongoing at the time of this report. Hundreds of patients have been treated, but
results are not followed up [exc...
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Overview of experimental therapies Oct2006

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Overview of experimental therapies Oct2006

  1. 1. Experimental* therapies using stem-cells applied to SCI [Spinal Cord Injury]. Date of report: October 19, 2006 Written by: Corinne Jeanmaire – SCI patient – corinne4cure@gmail.com – www.corinne4cureParalysis.blogspot.com Information below is based upon a few websites www.carecure.org, www.sci-therapies.info, www.asso-alarme.com, and on direct contact with some of the patients. *not including scientifically driven ‘clinical trials’ *Most of the therapies listed have the following characteristics in common : o Patients pay rather high amounts to undergo those therapies [ranging from 4000 to 100 000 Euro. Most of them cost about 15000/ 20000 Euro] and therefore cannot be called ‘clinical trials’ o Those therapies are carried out without any scientific follow-up of the patients, and for some of them, also without any scientific background and therefore cannot be called ‘clinical trials’ and can be dangerous. o They are often applied to various types of neurological issues such as MS, Stroke, ALS, next to SCI. o Some of them seem to have mainly commercial aim [which can have very dangerous effects], others seem to be both scientifically and commercially driven. o Results of those are not clear. A few patients reported significant/good results but those are not numerous. Most patients report either no results at all or a few improvement for which it is sometimes doubtful whether they come from the therapy or from other factors. A few patients reported some loss of function after undergoing the therapy! This document is for information only, it is in no way a recommendation to go for such experimental therapies, on the contrary, because those can be dangerous!
  2. 2. A. ADULT STEM-CELLS 1) Netherlands/Turkey-Azerbijan- Cells4Health. • Who? Cornelis Kleinbloesem : CEO of Cells4Health with headquarters in Netherlands but the procedures are outsourced in Turkey, Azerbijan or Belgium [light procedure only]. • Cells: bone-marrow stem-cells from the patient. • Patients: Spinal Cord Injury [SCI], Stroke, MS, ALS, … • Procedure: laminectomy or intrathecal injection or intravenous injection. • Publication: none • Results: doubtful. Some SCI patients reported loss of function. Only very few patients reported very light improvements. • Status: Cells4health is currently under investigation by the Dutch Inspection for Health. • Website: www.cells4health.com 2) Rotterdam, Netherlands -Dr. Trossel / PMC/ ACT cells • Who ? Dr Trossel, British Dr. Procedure is carried out at PMC, Preventiev Medisch Centrum Rotterdam. This program is offered in collaboration with ACT [Advanced Cell Therapeutics –see below], who reportedly provides the cells. • Cells: umbilical cord stem-cells, but not matched with the patient in any way. • Patients: at least SCI and MS patients have been treated. • Procedure: intravenous injection • Publication: none • Results: The little information available is by far not convincing. Some very slight improvements are reported by some SCI patients, who anyway had all an incomplete lesion and are therefore likely to progress. • Status: Dr Trossel was required to stop the treatment by Dutch Inspection of Health, early October, because during inspection, he could not indicate the source of some stem-cells found there!!!. Final decision is pending and should be taken by Dutch minister of health. 3) Worldwide:Advanced Cell Therapeutics (ACT) • Who ? company headquartered in Switerland [?] and specialized in stem-cells. The treatment to SCI patients is offered in various countries, e.g. the Netherlands [see above] and Mexico. Further, ACT has clinics/agreements in many countries around the world, including India, Trinidad, Brazil, Argentina, Turkey, Saudi Arabia, United Arab Emirates, Pakistan, and India. • Cells: Cord-blood stem cells.
  3. 3. • Results: no transparency. ACT does not reply when asked about patients’ results. • Website: www.stem-cells.com 4) Moscou- Russia - Dr. A. Bryukhovetskiy / Neurovita • Who: Treatment offered by Neurovita clinic. Dr. A. Bryukhovetsiy, former director of the Russian Navy’s Neurology Dpt. • Cells: autologous adult stem cells [hematopoietic stem cells from bone marrow]. Dr Bryukhovetsiy previously also transplanted embryonic/fetal stem cells. He does no longer do so due to the ethical controversy surrounding their use, their rejection potential, and, most importantly, his belief that autologous, adult stem cells are more effective. • Patients: so far, many SCI patients underwent the treatment. >100 ? • Procedure: laminectomy [open surgery] or intrathecally [puncture]. In that case, the patient can repeat the transfusion in two months, to enhance functional recovery. • Combination: Stem-cells are [sometimes] used in combination with Spherogel. • Publications: yes there was at least one publication by this doctor on the subject. • Status: treatment still ongoing at date of this report. • Website: www.neurovita.ru 5) Incheon, South Korea- Dr. Yoon Ha et al • Cells: Bone-marrow cells (BMCs) into the injury site of patients with acute SCI (7-14 days post injury) • Procedure: laminectomy • Combination: GMCSF [It is a factor that stimulates bone-marrow stem-cell proliferation, and animal models suggest that it may also 1) activate macrophages (immune cells) to remove myelin debris that inhibits axonal regeneration, and 2) inhibit post-injury cell death through a process called apoptosis] • Status: currently still ongoing ??? to be checked 6) Zhengzhou, China - Yongfu Zhang and colleagues • Cells: autologous bone-marrow stem cells • Patients: 90 patients with both acute and chronic SCI (info1st International SCI Treatments & Trials Symposium, Hong Kong, December 2005). • Status: ongoing? 7) Sofia, Bulgaria - Dr. Venceslav Bussarsky • Cells: autologous stem cells isolated from patient bone marrow
  4. 4. • Status: 12 patients had the procedure at time of report? 8) Buenos Aires, Argentina- Dr. Gustavo Moviglia et al • Cells : bone-marrow-derived mesenchymal stem cells • Patients: 2 sci patients had the procedure. • Combination: it combines a stem-cell approach with some of the immunological principles that underlie Dr. Michal Schwartz’ “activated macrophage”. • Status: supposedly good results reported in 2006 for the 2 patients. But the publication is controversial from scientific viewpoint. 9) Seoul, South Korea- Dr. K-S Kang et al. • Cells: stems cells isolated from umbilical cord blood (UCB). • Procedure: Laminectomy [open surgery]. • Scientific publication: ? • Result: press relates that one woman was treated, got very good functional return in a first period but later-on, her condition got worse than before the procedure and she also underwent extreme pain, supposedly due to an infection. • Status: ? 10) Shenzen, China -Beike Biotechnology Company • Who: Company created through funding by or collaborations with several major Chinese medical schools • Cells: umbilical cord stem-cells • Patients: a variety of neurological disorders, including SCI. • Combination: Stem-cells combined with nerve growth factor are injected • Procedure: surgical implantation combined with decompression[ being a potential confounding factor, as decompression of a lesion can, alone, often lead to improvements]. Also intrathecal and intravenous injection of the cells is carried out. • Website: www.stemcellschina.com • Status: treatment still ongoing at the date of this report. Many patients treated. 11) Monterrey, Mexico- Dr. Emilio Jacques • Cells : Umbilical cord stem cells. Sources indicate that Jacques has also started transplanting embryonic stem cells. • Procedure: open surgery with decompression followed by monthly stem-cell injections into surrounding muscles. • Status: info dated 2005: 59 SCI patients treated. Current status?
  5. 5. 15) Lisbon, Portugal – Dr Lima • Cells: Adult OEC from patient himself. Those are not, technically speaking, stem- cells, but are used in a similar way and with similar purpose. • Patients: many SCI patients [>100?] have been treated there since 2002 • Publication: yes [covering a few patients only] • Status: ongoing at the time of this report. Results are not followed up [except for a few patients covered by publication]. B- FETAL /EMBRYONIC CELLS /STEM-CELLS 12) Dominican Republic-Medra, Inc. • Who: under Dr. William Rader’s medical direction. Company headquartered in Malibu, California, but the surgeries are carried out in the Dominican Republic • Cells: hematopoietic stem cells derived from elective abortions, fetal • Patients: wide range of neurological and other disorders, including SCI. • Status: ongoing ? very controversial and doubtful program. Many sources consider it as dis-honest and warn people against going there. • Website: www.medra.com. 13) New Delhi, India-Dr. Geeta Shroff • Who ?: Dr Shroff, fertility specialist. • Cells: human embryonic stem cells. • Patients: many patients with diverse “incurable” disorders, including SCI. • Procedure: millions of cells cultivated from the human egg are intramuscularly or epidurally injected periodically into the patient over an extended period of time. • Scientific Publication: none. Also very few details about procedure and results. • Status: treatment carried out on many SCI patients at time of this report. Ongoing. 14) Beijing, China – Dr Huang • Cells: Fetal OEC from abortions. Those are not, technically speaking, stem-cells. • Patients: hundreds of patients [including Spinal Cord Injury, Stroke, Multiple Sclerosis, ALS] • Publication: yes.
  6. 6. • Status: ongoing at the time of this report. Hundreds of patients have been treated, but results are not followed up [except for a few patients covered by publication]. Clinical trial planned to take place in 2006/2007.
  7. 7. • Status: ongoing at the time of this report. Hundreds of patients have been treated, but results are not followed up [except for a few patients covered by publication]. Clinical trial planned to take place in 2006/2007.

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