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Amp keynote wilbanks


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Opening talk at the reproducible research workshop at AMP 2011, Vancouver.

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Amp keynote wilbanks

  1. 1. freedom (to reproduce) john wilbanks @creativecommons @wilbanks 14 July 2011
  2. 2. freedom .
  3. 3. 1. reproducibility > sharing. 2. best practices.3. freedom (as in “to reproduce”).
  4. 4. non-reproducible = people die.
  5. 5. CITATIONS 500 1000 1500 2000 2500 3000 0 ERa AR PPARa PPARg PR GR RARa VDR MR PXR LXRa available LXRb PPARd FXR Chemical probe TRb CAR RORg NGFIBa ERb NGFIBb HNF4a RORa SHP ERRa SF1 DAX Rev-erba RARb COUP2 RARg TRa ERRg LRH1 COUP1 availableNUCLEAR HORMONE RECEPTOR NGFIBg Rev-erbb RXRa RXRb No chemical probes RXRg the easier it is to reproduce chemically… PNR ERRb (slide courtesy of RORb GCNF Aled Edwards, SGC) TLX TR2 TR4 COUP3 HNF4g
  6. 6. reproducibility as collaboration.
  7. 7.
  8. 8. note: not a scientist.
  9. 9. 1. reproducibility > sharing. 2. best practices.3. freedom (as in “to reproduce”).
  10. 10. old school
  11. 11. new school
  12. 12. 1. reproducibility > sharing. 2. best practices.3. freedom (as in “to reproduce”).
  13. 13. reality.
  14. 14. “open” and “closed” aren’t even on the menu here.
  15. 15. re-identification
  16. 16. consenting to uncertainty.
  17. 17. Browser WindowFreedoms you are granting✓ Right to do research with your data✓ Right to redistribute your data✓ Right to publish results of research from your data✓ Right to commercialize products derived from research on your data
  18. 18. Browser WindowObligations you are imposing✓ I don’t want to be re-identified✓ Only health research allowed.
  19. 19. Browser WindowCheck to confirm that:✓ I understand the risks✓ I consent that my data can be used for research. Although I can withdraw at any time,✓ versions of my data that are already distributed may not be retrievable. Warning You must click yes on each element to proceed.
  20. 20. freedom .
  21. 21. freedom isn’t always about politics.