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PRE-ECLAMPSIA DURING PREGNANCY
Presented by :wesam telfah
Supervised by :dr bayan obeidat
PRE-ECLAMPSIA :
Definition :
a disorder associated with pregnancy consisting of
hypertension, proteinuria and new-onset de...
ECLAMPSIA
Definition-
“pre eclampsia complicated with seizures”
The preeclampsia stages :
PREECLAMPSIA STAGES :
 Altered placenta
formation
 Reduced utero placental
blood
 Fetal restriction growth
 Oxidative ...
HELLP SYNDROME
 Undiagnosed pre-eclampsia progresses to cause-
Haemolysis
Elevated Liver enzymes
Low Platelets
NORMAL PLACENTA VER UB NORMAL
MECHANISM OF PLACENTA
DYSFUNCTION:
FEATURING :
 Hypertension :
 systol > 140mmHg
or 30mm above pre-preg
 diastolic > 90 mmHg
or 15mm above pre-preg
 Two abnormal mea...
Proteinuria :
 Is defined as 300 mg/day
 Sever form of PE is hemolysis = elevated in liver
enzyme and low platelet synd...
EPIDEMIOLOGY :
 Freq (US)
pre-eclampsia: 6-8% of pregnancies
eclampsia: 0.05-0.2%
COMPLICATIONS/PROGNOSIS
 Permanent neuro damage
 Renal insufficiency
 Abruption
 Death
 25% of eclamptics will be so ...
MORTALITY/MORBIDITY
 Maternal: 8-36% most frequently related to
seizure activity
 Foetal: 13-30% most frequently related...
INVESTIGATION :
 Hypertension
 Urinalysis- proteinuria greater than 3+
 Blood tests
 CT head
SIGNS AND SYMPTOMS :
SYMPTOMS :
 Headache
 Oedema
 Visual disturbance
 Focal neurology, fits, anxiety, amnesia
 Abdominal pain
 low urine...
SIGNS :
 Hypertension
 Tachycardia and tachypnoea
 Creps or wheeze on auscultation
 Neurological deficit
 Hyperreflex...
RISK FACTORS :
 Low socioeconomic class
 Multiple foetuses, or hydatid
 Maternal age <20 or >35yrs
 Gestational or pre...
PE FREQ OVER AGE :
RISK FACTOR TO DEVELOPE OF
PREECLAMPSIA WITH INSULIN RESISTANCE:
Pre- pregnancy Pregnancy
Elevated serum insulin ,FFA ,TG ...
OUTCOME OF EXISTENCE OF PE:
Mother Newborn
Early delivery by cesarean
section
Growth restriction
Acute renal dysfunction R...
POTENTIAL PREVENTION :
CALCIUM INFLUENCE :
DRUGS :
P d
R
E i
E
C e
L
A t
M
P
S
I
A
NUTRITION INTERVENTION:
 1000 mg calcium daily = normal blood vessel
 600 mcg folate include 400 mcg folic acid
 Vit C ...
U-TUBE VIDEO ABOUT
PREECLAMPSIA:
 http://www.youtube.com/watch?v=wsS8rxA31jw
 http://www.youtube.com/watch?v=xzw1jhOP5b0...
ANY QUSTIONS ?
THANKS …….)
REFERENCES:
REFERENCES:
Pre eclampsia complication /jordan uni of science and technology
Pre eclampsia complication /jordan uni of science and technology
Pre eclampsia complication /jordan uni of science and technology
Pre eclampsia complication /jordan uni of science and technology
Pre eclampsia complication /jordan uni of science and technology
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Pre eclampsia complication /jordan uni of science and technology

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my presentation is talking about preeclampsia and it complication during pregnancy

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Pre eclampsia complication /jordan uni of science and technology

  1. 1. PRE-ECLAMPSIA DURING PREGNANCY Presented by :wesam telfah Supervised by :dr bayan obeidat
  2. 2. PRE-ECLAMPSIA : Definition : a disorder associated with pregnancy consisting of hypertension, proteinuria and new-onset dependent oedema, most commonly after 20 weeks of gestation”
  3. 3. ECLAMPSIA Definition- “pre eclampsia complicated with seizures”
  4. 4. The preeclampsia stages :
  5. 5. PREECLAMPSIA STAGES :  Altered placenta formation  Reduced utero placental blood  Fetal restriction growth  Oxidative stress  Inflamation  Apoptosis  Structural damage  Proteinuria elevated  Hypertyension  Angio spasm in brain  Brain edema lead to sever epileptic seizures -eclampsia Stage 1 Stage 2
  6. 6. HELLP SYNDROME  Undiagnosed pre-eclampsia progresses to cause- Haemolysis Elevated Liver enzymes Low Platelets
  7. 7. NORMAL PLACENTA VER UB NORMAL
  8. 8. MECHANISM OF PLACENTA DYSFUNCTION:
  9. 9. FEATURING :
  10. 10.  Hypertension :  systol > 140mmHg or 30mm above pre-preg  diastolic > 90 mmHg or 15mm above pre-preg  Two abnormal measurements, on two occasions, more than 6 hours apart
  11. 11. Proteinuria :  Is defined as 300 mg/day  Sever form of PE is hemolysis = elevated in liver enzyme and low platelet syndrome = ( HELLP ) .
  12. 12. EPIDEMIOLOGY :  Freq (US) pre-eclampsia: 6-8% of pregnancies eclampsia: 0.05-0.2%
  13. 13. COMPLICATIONS/PROGNOSIS  Permanent neuro damage  Renal insufficiency  Abruption  Death  25% of eclamptics will be so in future pregnancies  Increased risk of essential hypertension
  14. 14. MORTALITY/MORBIDITY  Maternal: 8-36% most frequently related to seizure activity  Foetal: 13-30% most frequently related to iatrogenic prematurity
  15. 15. INVESTIGATION :  Hypertension  Urinalysis- proteinuria greater than 3+  Blood tests  CT head
  16. 16. SIGNS AND SYMPTOMS :
  17. 17. SYMPTOMS :  Headache  Oedema  Visual disturbance  Focal neurology, fits, anxiety, amnesia  Abdominal pain  low urine output  Sensitivity of eye to bright light  None
  18. 18. SIGNS :  Hypertension  Tachycardia and tachypnoea  Creps or wheeze on auscultation  Neurological deficit  Hyperreflexia  Petechiae, intracranial haemorrhage  Generalised oedema  Small uterus for dates
  19. 19. RISK FACTORS :  Low socioeconomic class  Multiple foetuses, or hydatid  Maternal age <20 or >35yrs  Gestational or pre-gestational DM  Renal disease  Family history- four times the risk  Inadequate diet (vit C/E, Ca ,zink ,n-3 FA)  Homocysteine  Obesity and over wt
  20. 20. PE FREQ OVER AGE :
  21. 21. RISK FACTOR TO DEVELOPE OF PREECLAMPSIA WITH INSULIN RESISTANCE: Pre- pregnancy Pregnancy Elevated serum insulin ,FFA ,TG Genetic predisposition to HTN Disrupted platelet function Hormonal and metabolic changed Renal disease Nutritional status
  22. 22. OUTCOME OF EXISTENCE OF PE: Mother Newborn Early delivery by cesarean section Growth restriction Acute renal dysfunction Respiratory distress dysfunction Increased risk of GD,HTN,DM T 2 Rupture of placenta
  23. 23. POTENTIAL PREVENTION :
  24. 24. CALCIUM INFLUENCE :
  25. 25. DRUGS :
  26. 26. P d R E i E C e L A t M P S I A
  27. 27. NUTRITION INTERVENTION:  1000 mg calcium daily = normal blood vessel  600 mcg folate include 400 mcg folic acid  Vit C & E (200mg,400 Iu) respectivly  5 or more serving veg & fruit  Consumption of low glycemic index  No restriction of sodium intake  Moderate exersise
  28. 28. U-TUBE VIDEO ABOUT PREECLAMPSIA:  http://www.youtube.com/watch?v=wsS8rxA31jw  http://www.youtube.com/watch?v=xzw1jhOP5b0  http://www.youtube.com/watch?v=Ft-_0Bj9NNs
  29. 29. ANY QUSTIONS ?
  30. 30. THANKS …….)
  31. 31. REFERENCES:
  32. 32. REFERENCES:

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