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Using the Ruby programming language, the CWiid library, and the Ruby bindings for OpenGL, it is possible to develop a 3D game which is controlled using a Nintendo Wii Remote. By furthermore invoking RMagick and the ALSA library, one can add textures and sound to the game. Note that the library for accessing the Wii Remote (CWiid) and the sound library (ALSA) require Linux. However it is conceivable to do a similar project with alternate libraries on another operating system.
Also see http://www.wedesoft.demon.co.uk/shrug15.html