Successfully reported this slideshow.
We use your LinkedIn profile and activity data to personalize ads and to show you more relevant ads. You can change your ad preferences anytime.

The Scn V Final


Published on

  • Be the first to comment

The Scn V Final

  1. 1. The Suprachiasmatic Nucleus<br />Circadian Rhythm<br /> Biological Clocks <br />&<br />Genes<br />
  2. 2. Suprachiasmatic Nuclei<br />
  3. 3. SCN-The Clock<br />Regulates physiological functions<br />Circadian Pacemaker - e.g. sleep/wake, core body temp.<br />Temporal changes occur in a coordinated manner <br />Light/Dark cycle is removed –free running<br />Resetting of the clock<br />External Time Cues - Zeitgebers<br />
  4. 4.
  5. 5. Clock Timing<br />Based on Gene expression<br />Clock genes<br />Clock, Per2, Per3 (there are others and vary among species)<br />Reg. genetic transcription<br />Negative feedback loop<br />
  6. 6. Often Opposing Forces<br />Homeostatic drive-  <br />↑ with duration<br /> Adenosine buildup<br />Circadian rhythm- cyclic<br />↑ in evening due in part to melatonin secretion<br />