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The Scn V Final

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The Scn V Final

  1. 1. The Suprachiasmatic Nucleus<br />Circadian Rhythm<br /> Biological Clocks <br />&<br />Genes<br />
  2. 2. Suprachiasmatic Nuclei<br />
  3. 3. SCN-The Clock<br />Regulates physiological functions<br />Circadian Pacemaker - e.g. sleep/wake, core body temp.<br />Temporal changes occur in a coordinated manner <br />Light/Dark cycle is removed –free running<br />Resetting of the clock<br />External Time Cues - Zeitgebers<br />
  4. 4.
  5. 5. Clock Timing<br />Based on Gene expression<br />Clock genes<br />Clock, Per2, Per3 (there are others and vary among species)<br />Reg. genetic transcription<br />Negative feedback loop<br />
  6. 6. Often Opposing Forces<br />Homeostatic drive-  <br />↑ with duration<br /> Adenosine buildup<br />Circadian rhythm- cyclic<br />↑ in evening due in part to melatonin secretion<br />

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