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5 Manufacturing R2 Enhancements Life S

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5 Manufacturing R2 Enhancements Life S

  1. 1. Linda Hope Senior Industry Specialist Edgewater Fullscope
  2. 2. Potency Management
  3. 3. * APICS Dictionary (American Production and Inventory Control Society)
  4. 4. Active Standard Potency % Caustic . As less Quantity is needed, more Compensating Quantity is required As Potency increases, less Quantity of the Active Ingredient is required Sodium Hydroxide Potassium Hydroxide C Compensating
  5. 5. Active Standard Potency % Caustic . As more Quantity is needed, less Compensating Quantity is required As Potency decreases, more Quantity of the Active Ingredient is required Sodium Hydroxide Potassium Hydroxide C Compensating
  6. 6. Standard Potency % Fatty Acid Active Compensating OliveOil As Potency decreases, more Quantity of the Active Ingredient is required As more Quantity is needed, more Compensating Quantity is required
  7. 7. Standard Potency % Fatty Acid Active Compensating OliveOil As Potency increases, less Quantity of the Active Ingredient is required As less Quantity is needed, less Compensating Quantity is required
  8. 8. Filler Active Compensating Compensatio n Principle Complimentary Effect Compensating Opposing Effect
  9. 9. A batch of lower concentration (42.5%) has been selected which results in a increased required quantity for the Active ingredient. When the Balance batch ingredients is clicked, the Balanced quantity for the Compensating, Filler and other ingredients are calculated.
  10. 10. A batch of lower concentration (42.5%) has been selected which results in a increased required quantity for the Active ingredient. When the Balance batch ingredients is clicked, the Balanced quantity for the Compensating, Filler and other ingredients are calculated.
  11. 11. Pay Suppliers and value inventory based on the active ingredient quantity received. Most common price calculation: Price / Target Potency * Actual Potency received 50 Gallons 85% Active = $655.50 50 Gallons 82.5% Active = $636.22 50 Gallons 86.7% Active = $668.61 Price calculation may vary by supplier and item
  12. 12.    
  13. 13. • • •
  14. 14. Batch Order Sequencing
  15. 15. Batch Order Sequencing • – – – –
  16. 16. Batch Order Sequencing From this… To This… Flavor – Pack Size - Tablet Size Cleanup!
  17. 17. Simple Sequencing : Flavor Grape Banana Orange Minimizes Changeover And Cleanups Lemon Chocolate
  18. 18. Safe Sequencing : Drugs Ensure different products that look similar are never sequenced to follow each other
  19. 19. Using multiple sequences ranked within a sequence group provides the desired sequence Sequence 1: Flavor Sequence 2: Pack Type
  20. 20. Lot Inheritance
  21. 21. • • •
  22. 22. Co-Product A Batch Attributes Appearance white crystalline substance Melting point app. 65°C Solubility in water 680 g/l (20°C 1400 g/l (60°C) Alkaline resistance good Acid resistance decomposition Odour slight internal odour Delivery form powder, granules HS-Code 28 31 10 00 Chemical 123 Batch Attributes Appearance white crystalline substance Melting point app. 65°C Solubility in water 680 g/l (20°C 1400 g/l (60°C) Alkaline resistance good Acid resistance decomposition Odour slight internal odour Delivery form powder, granules HS-Code 28 31 10 00 Co-Product B Batch Attributes Appearance white crystalline substance Melting point app. 65°C Solubility in water 680 g/l (20°C 1400 g/l (60°C) Alkaline resistance good Acid resistance decomposition Odour slight internal odour Delivery form powder, granules HS-Code 28 31 10 00
  23. 23. Cell Culture 1 Blood Type: O + Cell Culture 2 Blood Type: O + Cell Culture 3 Blood Type: O + Cell Culture 4 Blood Type: O + Human Skin Tissue Blood Type: O +
  24. 24. Example: Assembly Expiry Date: 12/17/2012 Expiry Date: 12/21/2012 Expiry Date: 12/19/2012 Assembly Components Assembly will inherit the earliest shelf life of 12/17/2012
  25. 25. Example: Consumed inventory lots include these attributes and shelf life Shelf Life: Earliest Expiration date is 04/01/2013 Attribute Values: Unique attributes and values for each item and batch
  26. 26. Example: Batch for the formula item includes the batch attributes and shelf life dates of the consumed raw material batches Inherits earliest expiry date for consumed batches Inherits attributes of consumed lots and their respective values

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