Dr. Burke Product Power Point

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Dr. Burke Product Power Point

  1. 1. What is Nitric Oxide and Why Does the Body Need It? by Dr. Thomas Burke
  2. 2. What is Nitric Oxide (NO)? <ul><li>NO is one of the most powerful, endogeneous vasodilators. </li></ul><ul><li>Vasodilators improve circulation throughout the body. </li></ul><ul><li>In 1998 The Nobel Prize in Physiology or Medicine was awarded to 3 Americans for their discoveries concerning the Nitric Oxide molecule in the cardiovascular system. </li></ul>Robert F. Furchgott Louis J. Ignarro Ferid Murad
  3. 3. Why does the body need NO? <ul><li>The Answer: Better Circulation </li></ul><ul><ul><li>Dilates existing vessels; arterioles, venules and lymphatics. </li></ul></ul><ul><ul><li>Angiogenesis - the growth of new blood and lymph vessels. </li></ul></ul><ul><ul><li>Decreases edema and swelling. </li></ul></ul><ul><ul><li>Increases nutritional flow to cells. </li></ul></ul><ul><ul><li>Increases antibiotic delivery and action. </li></ul></ul><ul><ul><li>Restores blood flow to nerves. </li></ul></ul>
  4. 4. What about Diabetics and NO? <ul><li>Diabetic patients have less NO in their bodies than those who are not diabetic. </li></ul><ul><ul><li>Reduced production of Nitric Oxide in the body. </li></ul></ul><ul><ul><li>Can’t release Nitric Oxide as well as healthier people do. </li></ul></ul><ul><ul><li>High blood glucose destroys Nitric Oxide. </li></ul></ul><ul><ul><li>Diabetic patients have many different circulation problems. </li></ul></ul>
  5. 5. Circulation is Critical <ul><li>Better circulation is critical to helping patients with diabetes or other health challenges. </li></ul><ul><ul><li>Decrease pain, especially ischemic pain from inadequate blood supplies to organs or parts of the body. </li></ul></ul><ul><ul><li>Restore sensation to help prevent falls. </li></ul></ul><ul><ul><li>Assists in the recovery of wounds. </li></ul></ul>
  6. 6. Supporting Research <ul><li>Who says Nitric Oxide may be important regarding falls with the elderly? </li></ul><ul><ul><li>Diabetes Mellitus is associated with an increases risk of falls in elderly residents of a long-term care facility. </li></ul></ul><ul><ul><li>Maurer MS, Murcham J, Cheng H </li></ul></ul><ul><ul><li>Gerontol A Biol Sci Med Sci. 2005;60:1157-62 </li></ul></ul>
  7. 7. Nitric Oxide, Circulation and Wounds <ul><li>Diabetic Ulcers </li></ul><ul><li>Pressure Ulcers </li></ul><ul><li>Venous Stasis Ulcers </li></ul><ul><li>Arterial Ulcers </li></ul><ul><li>Gangrene </li></ul><ul><li>Post-op </li></ul>
  8. 8. Supporting Research <ul><li>Who says Nitric Oxide may be important in wound healing? </li></ul><ul><ul><li>Shaffer MR, Tantry U, Gross SS, Wasserburg HL, Barbul A. </li></ul></ul><ul><ul><li>Nitric Oxide regulates wound healing. </li></ul></ul><ul><ul><li>J Surg Red. 1996;63:237-240 </li></ul></ul>
  9. 9. Additional Research <ul><li>Raynaud’s Syndrome </li></ul><ul><ul><li>Tucker AT, Pearson RM, Cooke ED, Benjamin N. </li></ul></ul><ul><ul><li>Effect of Nitric Oxide generating system on microcirculatory blood flow in skin of patients with severe Raynaud’s Syndrome: a randomised trial. </li></ul></ul><ul><ul><li>Lancet 1999 Nov 13;354(9191):1670-5 </li></ul></ul><ul><li>NO and Pain Relief </li></ul><ul><ul><li>Ferreira SH, Duarte ID, Lorenzetti BB. </li></ul></ul><ul><ul><li>The molecular mechanism of action of peripheral Morphine Analgesia: stimulation of the cGMP system via Nitric Oxide release. </li></ul></ul><ul><ul><li>Eur J Pharmacol 1991;201:121-122 </li></ul></ul>
  10. 10. Additional Research <ul><li>Fibromyalgia </li></ul><ul><ul><li>Jeschonneck M, Grohmann G, Hein G, Sprott H. </li></ul></ul><ul><ul><li>Abnormal microcirculation and temperature in skin above tender points in patients with fibromyalgia. </li></ul></ul><ul><ul><li>Rheumatology (Oxford) Aug. 2000;39(8):917-21 </li></ul></ul><ul><li>L-Arginine </li></ul><ul><ul><li>Roger RH, Bode-Boger SM, Thiele W, Creutzig A, Alexander K, Frolich JC. </li></ul></ul><ul><ul><li>Restoring vascular Nitric Oxide formation by L-Arginine improves the symptoms of intermittent claudication in patients with peripheral arterial occlusive disease. </li></ul></ul><ul><ul><li>J Am Coll Cardiol 1998;32:1336-44 </li></ul></ul>
  11. 11. Additional Research <ul><li>Plastic Surgery </li></ul><ul><ul><li>Um SC, et al; </li></ul></ul><ul><ul><li>Involvement of Nitric Oxide in survival of random pattern skin flap. </li></ul></ul><ul><ul><li>Plast Reconstr Surg 1998;101:785-92 </li></ul></ul><ul><li>Fractures </li></ul><ul><ul><li>Diwan AD, Wang MX, Jang D, Zhu W, Murrell GA. </li></ul></ul><ul><ul><li>Nitric Oxide modulates fracture healing. </li></ul></ul><ul><ul><li>J Bone Miner Red. 2000;15:324-51 </li></ul></ul><ul><li>Tendons </li></ul><ul><ul><li>Murrell GA, Szabo C, Hannafin JA, Jang D, Dolan MM, Deng XH, Murrell DF, Warren RF. </li></ul></ul><ul><ul><li>Modulation of tendon healing by Nitric Oxide. </li></ul></ul><ul><ul><li>Inflamm Res. 1997;46:19-27 </li></ul></ul>
  12. 12. Increased Circulation Responsive Conditions <ul><li>Inflammation/Infection </li></ul><ul><ul><li>Bursitis </li></ul></ul><ul><ul><li>Osteoarthritis </li></ul></ul><ul><ul><li>Tendonitis </li></ul></ul><ul><ul><li>Plantar Facitis </li></ul></ul><ul><ul><li>Lateral Epichondylitis </li></ul></ul><ul><ul><li>Neuritis </li></ul></ul><ul><ul><li>Synovitis </li></ul></ul><ul><ul><li>Bell’s Palsy </li></ul></ul><ul><ul><li>Cellulitis </li></ul></ul><ul><ul><li>Ostemoelitis (IV Antibiotics) </li></ul></ul><ul><li>Range of Motion Deficits </li></ul><ul><ul><li>Frozen Shoulder </li></ul></ul><ul><ul><li>Contractures </li></ul></ul><ul><li>Orthopedic </li></ul><ul><ul><li>Non-Union/Jones Fractures </li></ul></ul><ul><ul><li>Degenerative Disc </li></ul></ul><ul><li>Chronic Wounds </li></ul><ul><ul><li>Venous, Pressure Ulcers (Arterial) </li></ul></ul><ul><ul><li>Diabetic Wounds </li></ul></ul><ul><ul><li>Post Op </li></ul></ul><ul><ul><li>PVD </li></ul></ul>
  13. 13. Increased Circulation Responsive Conditions <ul><li>Pain </li></ul><ul><ul><li>Fibromyalgia </li></ul></ul><ul><ul><li>Neuralgia </li></ul></ul><ul><ul><li>Neuropathic Pain </li></ul></ul><ul><ul><li>Ischemic Pain </li></ul></ul><ul><ul><li>Chronic Pelvic Pain </li></ul></ul><ul><li>Nerve Entrapments </li></ul><ul><ul><li>TMJ </li></ul></ul><ul><ul><li>Carpal Tunnel Syndrome </li></ul></ul><ul><ul><li>Tarsal Tunnel </li></ul></ul><ul><li>Swelling </li></ul><ul><ul><li>Edema </li></ul></ul><ul><ul><li>Lymphedema </li></ul></ul><ul><ul><li>Sprains and Strains </li></ul></ul><ul><li>Post Operative </li></ul><ul><ul><li>Reduce Swelling and Pain </li></ul></ul><ul><ul><li>Speed Recovery </li></ul></ul><ul><ul><li>Reduce Adhesions/Scarring </li></ul></ul>
  14. 14. NO and Health Benefits Summary <ul><li>Increased Circulation through Nitric Oxide which will… </li></ul><ul><ul><li>Reduce pain and restore sensation. </li></ul></ul><ul><ul><li>Improve gait and balance. </li></ul></ul><ul><ul><li>Help with would recovery. </li></ul></ul><ul><ul><li>Assist in fracture/tendon recovery. </li></ul></ul><ul><ul><li>Great deal of research to support benefits. </li></ul></ul><ul><ul><li>Assist in Plastic Surgery recovery. </li></ul></ul><ul><ul><li>Workman’s compensation reduced. </li></ul></ul>
  15. 15. What is Nitric Oxide and Why Does the Body Need It? by Dr. Thomas Burke

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