Topical Anesthetics: Are They Worth The Effort?

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Topical Anesthetics: Are They Worth The Effort?

  1. 1. Topical Anesthetics: AreThey Worth The Effort?
  2. 2. Topical Anesthetics: Are They Worth The Effort? Prospective, randomized controlled trials addressing the use oftopical anesthetics during upper endoscopy for improved patienttolerance have been mixed . Existing study designs differ in the presence of double-blinding, thetype of topical anesthetic employed, endoscope diameter, and the useof conscious sedation. Soma et al. Recently conducted a study of 201 Japanese patients who wererandomized to receive either 2% lidocaine or placebo. No conscious sedation was employed. Multivariate analysis found that the use of topical anesthesiareduced the relative risk of discomfort by 44% (95% CI: 0.31–1.01). Patient age less than 40 was associated with a higher relative riskof discomfort (RR 2.22, 95% CI: 1.04–4.74). Subgroup analysis found that patients less than 40 years of agewho were pretreated or those undergoing endoscopy forthe first time benefited most from topical anesthesia.http://www.gastrohep.com/ebooks/ebook.asp?book=1405120762&id=3#top

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