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- 1. DNA repair
- 2. Mutations
- 3. The Ames Test
- 4. The repair systems <ul><li>Mainly, the undamaged complementary strand acts as a template for the DNA polymerases involved in repair </li></ul><ul><ul><li>Mismatch repair </li></ul></ul><ul><ul><li>Base excision repair </li></ul></ul><ul><ul><li>Nucleotide excision repair </li></ul></ul><ul><ul><li>Direct repair </li></ul></ul><ul><ul><li>Recombinational repair </li></ul></ul><ul><ul><li>Error-prone repair </li></ul></ul>
- 5. Mismatch repair
- 6. Mismatch mechanism
- 7. Mutations in mut proteins?
- 8. Base excision repair
- 9. Repairing apurinic and apyrimidinic sites
- 10. Nucleotide excision repair
- 11. Mutations in excision repair systems
- 13. Direct repair
- 14. Methyltransferase
- 15. When both strands are damaged
- 16. SOS system
- 17. Recombination
- 18. Recombination <ul><li>Three forms </li></ul><ul><ul><li>Homologous </li></ul></ul><ul><ul><li>Site specific recombination </li></ul></ul><ul><ul><li>Transposition </li></ul></ul>
- 19. Recombinational repair
- 20. DNA replication stalled because of lesion Replication continues Repair Recombination Blockade
- 21. Replication following a break Blockade Recombination Reseal
- 22. Meiotic recombination
- 23. Recombination between homologous a chromosomes
- 24. Recombination permits genetic mapping If each recombinant occurs at 2.5%, then the total map distance is 5% or 5 m.u. 1 2 3 Generation
- 25. The simple minded mechanism (incorrect) of meiotic recombination
- 26. Gene conversion indicates that another mechanism must be operable
- 27. Gene conversion on a molecular level
- 28. The mechanism of homologous recombination
- 29. The topology of the Holliday structure
- 30. Resolution of the Holliday structure
- 31. Non-identical sequences
- 32. The enzymes of recombination
- 33. Rec A
- 34. Site specific recombination
- 35. Site specific recombination within one molecule
- 36. Use of recombinase to resolve a dimeric genome
- 37. Transposition
- 38. Direct transposition
- 39. Replicative transposition
- 40. Retroviruses

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