Successfully reported this slideshow.
We use your LinkedIn profile and activity data to personalize ads and to show you more relevant ads. You can change your ad preferences anytime.

Pathology of Testes tumours

1,547 views

Published on

pathology of testicular tumours.

Published in: Health & Medicine
  • Login to see the comments

Pathology of Testes tumours

  1. 1. CLINICAL PATHOLOGY The foundation of clinical medicine. Shashidhar Venkatesh Murthy A/Prof & Head of Pathology College of Medicine & Dentistry MGS4: Male Genital: Testes Tumors CPC : Term4 Week4 - MGS 4/6 System : Male Genital System. Topic : 1: Overview 2: STD 3: Orchitis 4: Tumours 5: Penis 6: GLS
  2. 2. 3 Testes Tumors: Features:  Commonest tumour of young males, painless swelling.  Etiology: Idiopathic, Undescended testes (10%, 10 times)  Classification:  95% Germ cell Tumours,  Seminoma 45% - good prognosis.  Non seminoma (NSGT) 45% - poor prognosis. Embryonal ca, Teratoma, Chriocarcinoma, Mixed - common  5% Sertoli / Leydig cell tumours.  Clinical features:  Adults 20-40y – Seminoma.  Children <10y – NSGT- Yolksac tum.  Painless, dragging, unilateral, solid.  Metastases – Para aortic LN*.
  3. 3. 4 Seminoma:  Commonest Germ cell tumour, 20-40y.  Firm, grey, smooth, painless,  Many subtypes: classical*, spermatocytic etc..  Microscopy: uniform clear cells + lymphocytes.  Mixed seminoma  Seminoma + Teratoma, embryonal carcinoma or choriocarcinoma (βhCG 10%). Etc.
  4. 4. 5 Seminoma Testes: Lymphocytes Clear cells
  5. 5. 6 Seminoma Testes: Lymphocytes Clear tumour cells
  6. 6. 8 NSGT: Embryonal Ca  Clinical: painless swelling, hemorrhagic, malignant, poor prognosis, metastases.  Germ cell tumor – embryonic cells.  Gross: Hemorrhagic, necrotic tumor.  Adults: Embryonal Ca.  Children: Yolksac tumor.  Tumor Marker: AFP (α feto protein)  Microscopy: Pleomorphic cells, embryoid structures. Pink AFP globules in cells.
  7. 7. 9 NSGT: Teratoma / Teratocarcinoma  > 1 tissue type (mature / immature)  Teratoma + other germ cell tum (Embryonal ca)  Common, 10-30y, aggressive, poor prognosis.  Both βhCG & AFP +ve - if mixed.
  8. 8. 10 Testes Tumors: summary  Germ cell Tumours (95%)  Gonadal: Seminoma Non Seminoma Germ Cell tum (NSGT)  Embryonic: Embryonal ca.  Extraembryonic: Yolk sac tum, Choriocarcinoma.  Somatic: Teratoma  Mixed: (40%) Tumor – Incidence Age Tumor Marker Seminoma 50% 40-50y 10% βhCG Embryonal ca. 20-30y Negative (pure) Yolk sac tumour < 3y 90% AFP Choriocarcinoma 20-30y 100% βhCG Teratoma (Pure) All ages Negative Mixed 15% 15-30y 90% βhCG & AFP

×