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Curcumin tablet 500mg

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Curcumin tablet 500mg

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Contains curcuminoids such as curcumin (diferuloylmethane), demethoxycurcumin, and bisdemethoxycurcumin Free radical mediated Useful against skin infections; Treat boils efficiently
Protects skin from the damaging effects of UV B radiation
Reduce formation of wrinkles on the skin; anti-ageing

Contains curcuminoids such as curcumin (diferuloylmethane), demethoxycurcumin, and bisdemethoxycurcumin Free radical mediated Useful against skin infections; Treat boils efficiently
Protects skin from the damaging effects of UV B radiation
Reduce formation of wrinkles on the skin; anti-ageing

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Curcumin tablet 500mg

  1. 1. Curcumin (Curcuma longa) Extract standardized for 95% curcuminoid complex A Scientific Overview on the role of CURCUMIN in Cancer prevention & treatment
  2. 2. The discovery of curcumin dates back to around two centuries ago, when Vogel and Pelletier reported the isolation of “yellow coloring - matter” from the rhizomes of Curcuma Longa and named it Curcumin. Later this substance was found to be a mixture of resin and turmeric oil. In 1842, Vogel Jr. obtained a pure preparation of curcumin but did not report its formulas. In the decades that followed, several chemists reported possible structures of curcumin. However, it was not until 1910 that Milobedzka and Lampe identified the chemical structure of curcumin as diferuloylmrthanr, or 1,6-hepatadiens-3,5-dione-1,7-bis(4-hydroxy-3-methoxyphenyl)-(1E,6E). Further work by the same group in 1913 resulted in the synthesis of the compound. Subsequently, Srinivasan separated and quantified the components of curcumin by chromatography in 1953 When Mother Nature designed curcumin, she gave it the ability to target numerous critical mechanisms essential for the development growth and progression of most cancers. Most pharmaceutical drugs are designed to work only a single target (i.e. a cellular receptor, gene, protein, etc) or physiologic pathway (i.e. inflammation, glucose metabolism, immune modulations, etc.) However, the more we learn about cancer, the more we recognize that in most cases each cancer is driven by a complex array of hundreds-to-thousands of targets and pathways. It is due to this complexity that, (some rare exceptions) scientists have been unable to discover a “silver bullet” cure for most cancers. Curcumin is one of the hottest plant polyphenol extracts being researched today. The studies have been done dating back to over 170 years. But, in the last 10 years alone, there have been over 5000 scientific papers published on curcumin. Many of these studies suggest that this compound could be useful in the prevention and treatment of a wide spectrum of medical conditions and physiologic process (i.e. cancer, inflammatory disease. cystic fibrosis, Alzheimer’s disease etc) Curcumin (Curcuma longa) Extract standardized for 95% curcuminoid complex
  3. 3. Curcumin (Curcuma longa) Extract standardized for 95% curcuminoid complex A huge number of compounds are widely distributed in nature and many of these possess medicinal/biological/pharmacological activity. Curcumin, a polyphenol derived from the rhizomes of Curcuma longa, is a culinary spice and therapeutic used in India for thousands of years. Curcumin has many beneficial pharmacological effects which includes, but are not limited with, antimicrobial, anti-inflamatory, antioxidant, antiviral, antiangiogenic, neurodegenerative diseases and antidiabetic activities. More over, curcumin possesses immense antitumorigenic effect. It prevents tumor invasion and metastasis in a number of animal models in various conditions. Invasion and metastasis are considered as one of the hallmarks in cancer biology. The pertinent recent applications of curcumin as anti-invasive and antimetastatic agent in in vitro, in vivo and ex vivo studies as well as associated molecular mechanisms has been well documented in the recent past. Curcumin has also demonstrated the ability to improve patient outcomes in clinical trials.
  4. 4. In Jethro Klauss’s book, Back to Eden, there is no mention of turmeric at all. This indicates, that the herbal schools of Dr.Christoper and Jethro Klauss were not aware of the potential of turmeric, which was well known to Asian Herbalists. alternative tonic. There was a disconnect b Curcumin (Curcuma longa) Extract standardized for 95% curcuminoid complex “
  5. 5. Inducer of detoxifying enzymes Elevating cellular levels of enzymes involved in the phase 2 reactions. e.g.glutathione-S- transferase (GST), glucuronosyl-transferase, are widely recognized as an important stratergy against carcinogenesis. Curcumin is a potent inducer of phase 2 enzymes. Modulator of cell signaling targets Normal cells do not proliferate without mitogenic stimulatory signals. However, self-sufficiency of these growth signals has been an accepted mark of cancer cells. Curcumin inhibits NF-KB (nuclear factor kappa B), MAPK (mitogen-activated protein kinases), AP-1, (Activator protein-1), Janus kinases and signal transducers and activators of transcription (JAK/STAT) pathway, Cyclo oxygenase and Lipo oxygeneases (COX/LOX) pathways, matrix metalloproteinases (MMPs), tumor necrosis factor- (TNF-  ) and induces degradation of Receptor Tyrosine Kinases Regulation of Cell cycle Various genes affecting cell cycle progression have been identified as tumor suppressor genes. Curcumin inhibits cyclins and cyclin-dependent kinases (cyclin D1) and Telomerase. Induction of apoptosis Curcumin induces cytotoxicity in tumor cells by the induction of apoptosis. Curcumin inhibits NF-KB, downregulates the expression of Bcl-2, and Bcl-XL and upregulates the expression of Bax and Bak in cancer cells, inhibits Akt activity and downregulates Notch expression levels. t “Western herbalists, wake up! Turmeric is a healer” Curcumin (Curcuma longa) Extract standardized for 95% curcuminoid complex
  6. 6. Curcumin inhibits different stages of cancer progression Normal Cells Tumour Cells Tumor Growth Tumor Metastasis InvasionTransformation Proliferation Breast Cancer VEGF b-FGF MMP-2 COX-2 NF-κB Hematological Cancers (Leukemia, Lymphoma) P27kipl Cyclin-D3 STAT-3 JAK-1 AP 1 NF-κB IL-6 IL-8 IL-10 AP 1 NF-κB NAT STAT-1 Thoracic/H & N Cancers (Lung, Oral, Thymus) Gastrointestinal Cancers (Intestine, Liver, Stomach, Pancreas, Colorectal) Genitourinary Cancers (Prostate, Kidney, Bladder) BCl-2 BCl-xL Cyclin-D1 AP 1 Gynecologic Cancers (Cervix, Ovary, Uterus) Ets-1 BCl-2 NF-κB AP 1 Anti Cancer activity of Curcumin in various types of cancer Curcumin (Curcuma longa) Extract standardized for 95% curcuminoid complex
  7. 7. rmation and cell migration and exert signifi Curcumin (Curcuma longa) Extract standardized for 95% curcuminoid complex
  8. 8. Vin Super Foods (VSF), a division of Vidya Herbs Pvt Ltd., is a leading exporter of herbal extracts to the USA, European & Asian countries. VSF presents a wide range of individual herbal formulations. The actions of these extracts benefit the individuals, irrespective of the body’s constitution, health condition and metabolic functions. From the goodness of these herbs, everyone will be benefitted. The pharmacological actions of these herbs are well defined & have remarkable benefits. VSF products are based on the extraction of bioactive compounds from botanicals to maximize their benefits. Each herb is extracted for its most active compound through supercritical CO2 extraction process, with its inherent chemical balance unaltered, to ensure a high quality of medicinal extract which will be of more than 95% purity. The efficacy of our products are supported by scientific and clinical research, and protected by statutory guidelines. Our products are Natural in origin and are completely safe. Botanicals makes it good, while science makes it great. VIN SUPER FOODS, #30, Vinaya Arcade, 2nd Floor, 33rd Main, J P Nagar 6th Phase, Bangalore - 560 078, Ph : +91 80 4174 3116 A Group company of Vidyaherbs Pvt. Ltd www:vidyaherbs.com, www:vinsuperfoods.com

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