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My first talk in German on informatics in disease systems

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My first talk in German on informatics in disease systems

  1. 1. beispiele von Alzheimer’s und AIDS vineeth surendranath, doktorand, gruppe tomancak was hat Informatik zu tun mit Krankheiten ? 000001000010101001101111111 111110010000000101000000001 101001101111111011001000010 000101000000000000010010000 000101000000000000010010000 01001101111111011001000010 000001000010101001101111111 111110010000000101000000001 101001101111111011001000010 000101000000000000010010000 10100110111111101100100001 00010100000000000001001000
  2. 2. “... Ein Beweis für die Widerstandsfähigkeit des menschlichen Kreativität” Crutch, Isaacs & Rossor, Lancet 2001 Selbstportrait, William Utermohlen (1967)
  3. 3. Selbstportraits, William Utermohlen (1933-2006) 1996 1997 1997 1998 1999 2000
  4. 4. 1954 1978 1995 “Wir alle haben Angst verrückt zu sein. Wie sollten wir es auch wissen, die, die im Kopf leben ?”
  5. 5. Zentrales Dogma der Molekularbiologie Gene RNA Protein
  6. 6. Thomas H Morgan & seine Fruchtfliegen
  7. 7. Zentrales Dogma der Molekularbiologie gene 1 2 3 4 exon mRNA 1 2 3 4 mRNA 1 3 4 protein protein
  8. 8. RNA interferenz gene 1 2 3 4 exon mRNA 1 2 3 4 mRNA 1 3 4 protein protein
  9. 9. RNA interferenz
  10. 10. RNA interferenz dsRNA DICER siRNA pool RISC protein components RISC siRNA unwinding Activated RISC association with target mRNA target mRNA cleavage
  11. 11. Molekulare Ursache für Alzheimer’s APP ↓ β-secretase(BACE1) APPsβ ↓ β-stub γ-secretase Aβ Aβ Aβ Aβ Aβ
  12. 12. RNA interferenz APP! "! !-secretase! APPs!! "! !-stub! #-secretase! A!! A!! A!! A!! A!!
  13. 13. RNA interferenz 25000 gene 200
  14. 14. Numerische Mathematik, Vol. 1, 269-271, 1959 5 1 2 3 4 6
  15. 15. 7 5 1 2 3 4 6 1 2 3 1 7 3 1 6 3
  16. 16. Protein Netzwerk im Alzheimer’s
  17. 17. HIV genome
  18. 18. "Wenn ich weiter sehen konnte, so deshalb, weil ich auf den Schultern von Riesen stand." Isaac Newton
  19. 19. Frank Buchholz Ralf Kittler Janet Chusainow Jitin Bali Lawrence Rajendran Gruppenleiter Assistant Professor Wissenschaftler Doktorand, Psychiatrische Forschung Professor, Psychiatrische Forschung MPI-CBG, Dresden Southwestern Medical Center MPI-CBG, Dresden Universität Zürich Universität Zürich Texas Universität, USA "Wenn ich weiter sehen konnte, so deshalb, weil ich auf den Schultern von Riesen stand." Isaac Newton

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