Insulin plant is a relatively new entrant to Kerala and India. Insulin plant has not got a Malayalam name yet, except the occasional use of insulin chedy or insulin chedi, where chedy means a plant. The catchphrase of this plant is a leaf a day keeps diabetes away.The plant is characterized by large fleshy looking leaves. It grows very quickly. Propagation is by stem cutting. It grows in slightly shady areas.Diabetes patients are advised to chew down a leaf in the morning and one in the evening for a month. Allopathic doctors too recommend it and it is found to be effective in bringing blood sugar levels under completely under control. There is also dried and ground powder of the leaves now available in the market.
* With FBS below 200, take ONE leaf daily before breakfast and drink a glass of water
* With FBS above 200, take TWO leaves in the morning and TWO at night on a daily basis.
www.natureherbs.org 2012ABSTRACTThe present study was carried out to evaluate the antidiabetic activity of Costus pictus(C.pictus) D. Don, on alloxan induced diabetic rats. Oral administration of fresh leaf extract (200and 400 mg/kg body weight) for 60 days treatment resulted in significant decrease in bloodglucose level and lipid profiles. There were also significant changes observed in carbohydratemetabolizing enzymes and antioxidants. The nitrogenous wastes such as urea, uric acid andcreatinine were also found decreased after the treatment. The study clearly shows that theeffect of the drug (400 mg/kg body weight) was equally effective with the standard drugglibenclamide. To find out the biomarkers, pharmacognostic and phytochemical studies werecarried out . The leaf of C. pictus is characterized by simple unicellular, pointed non-glandulartrichomes, absence of palisade layer and hypodermal layers containing shattered crystals.Micromorphological characters of the leaf are also given. The leaves are found to containflavonoids such as kaempferol, 3’, 4’-di O-Me-quercetin and 4’-OMe-Kaempferol and phenolicacids such as gentisic, 2, 5-dihydroxy benzoic acid, o-coumaric, melilotic, α-resorcyclic, 3,5-dihydroxy benzoic acid, p- hydroxy benzoic acid, cis and trans-p-coumaric acid.INTRODUCTIONDiabetes mellitus is a disorder very well known and widespread all over the world. Differenttypes of oral hypoglycemic agents such as insulin, suphonylurea etc. are used for the email@example.com | +91 841 888 5555
www.natureherbs.org 2012of this disease, but they cause side effects on continued use. There is a growing interest inphytomedicine because of their effectiveness, fewer side effects and low costs. Many Indianmedicinal plants are reported to be useful in diabetes. C. pictus D.Don. (Costaceae) anornamental plant of Mexico, is one such plant newly introduced to India. It is an erect herbgrowing up to 3 meters tall, having stem horizontally striped at base; leaves narrowlylanceolate, dark green above, lighter green below; small leaves are present on the basal part;bracts green, with outer margin coloured maroon. Flowers yellow; lip with maroon striations,darker yellow stripe down the middle region; anther cream coloured. This plant is distributedalong the coast from Mexico to Costa Rica and is locally known as cana agria or cana de jabali inMexico. In Mexico, it is used to treat diseases of the kidney. It is reported to have effects onrenal functions and its anti-inflammatory and hypoglycemic actions. The practitioners inMexico used an infusion of this plant in the treatment of renal disorders; the plant alsopossesses diuretic activity. The plant was reported to contain flavonoids, saponins, reducedsugars and tannins.The present study was undertaken to test the plant for its antidiabetic activities, toxicity of theextract on normal rats and the effect of the extract on the antioxidant enzymes, non- enzymaticantioxidant, carbohydrate metabolizing enzymes and lipid profile. Pharmacognostic andphytochemical analysis of the leaves were also conducted.Insulin plant is a relatively new entrant to Kerala and India. Insulin plant has not got aMalayalam name yet, except the occasional use of insulin chedy or insulin chedi, where chedymeans a plant. The catchphrase of this plant is ‘ a leaf a day keeps diabetes away’ .The plant is characterized by large fleshy looking leaves. It grows very quickly. Propagation is bystem cutting. It grows in slightly shady areas.Diabetes patients are advised to chew down a leaf in the morning and one in the evening for amonth. Allopathic doctors too recommend it and it is found to be effective in bringing bloodsugar levels under completely under control. There is also dried and ground powder of theleaves now available in the market.* With FBS below 200, take ONE leaf daily before breakfast and drink a glass ofwater* With FBS above 200, take TWO leaves in the morning and TWO at night on adaily firstname.lastname@example.org | +91 841 888 5555
www.natureherbs.org 2012MATERIALS AND METHODSPreparation of aqueous extractThe leaves of C. pictus (Costaceae) were collected from Vadodara City, Gujarat. A Voucherspecimen was deposited in the herbarium of the Botany department of M. S. University. Forpreparing the extract, 500 g of Fresh leaves were boiled in water for 30 min. The extract wasthen filtered and the process of boiling was repeated three times with the residue, each timecollecting the extract. The collected extract was pooled and passed through a fine muslincloth. The filtrate upon evaporation at 40°C yielded 14.5% semi solid extract.Lipids in the diabetic subjects is mainly due to an increase in the mobalization of free fatty acidsfrom the peripheral fat deposit . The hypolipidemic effect of C. pictus could be explained asa direct result of the reduction in blood glucose email@example.com | +91 841 888 5555
www.natureherbs.org 2012CONCLUSIONThe present findings suggest that the plant extract is non- toxic, since no marked changes wereobserved in the normal rats fed with the extract. Thus, at normal therapeutic doses, the extractwas considered to be safe for long-term treatment in diabetic condition. The leaf extractshowed potent antidiabetic activity and the dose 400mg/kg body weight was more effectivethan 200 mg/kg body weight. 400 mg dose was all most equally effective with the standarddrug glibenclamide. Apart from this the plant extract also improved the activity ofenzymatic and non-enzymatic antioxidants, thereby scavenging the free radical that initiatesthe lipid peroxidation. The decreased level of urea, uric acid and creatinine in the treated ratsclearly shows that the plant extract, protects the diabetic rats from alloxan induced renaldamage. The plant extract also lowered the plasma lipid levels, the antihyperlipidemiceffect of the extract in particular can be considered as a possible therapeutic value. Theresult observed in all these parameters were statistically significant (p<0.05). Thus all theseactivities exhibited by the extract can be attributed to the presence of the active constituent ofthe plant. Longer duration studies of C. pictus extract and its isolated compounds are necessaryto develop a potent antidiabetic firstname.lastname@example.org | +91 841 888 5555