Dubielzig Ophtho Lab 2006-04-18 09: 40: 49--<fS00 R. R. Dubielzig Fax p. 1/1 PATHOLOGY REPORT Richard R. Dubielzig, DVM DipL ACVP Dept. of Pathobiological Science School of Veterinary Meclicine Research No.: 06RD0781 Ophthalmic Pathology Service University of Wisconsin 2015 Linden Dri ve Madison, WI 53706 Date of Typed Report: April 17, 2006 Referring Veterinarian: Owner: Animal: Beckman Higley Tessa The sample submitted consists of the formalin-fixed soft tissue biopsies from the gingival and lip of a 6-year-old female dog of unspecified breed. Both biopsies were sliced to maximize sUlface area examined. Six sections are examined. Histologically, the samples contain fragments of collagenous stroma lined externally by mildly hyperplastic gingival epithelium. Within the stroma, there are sparse foci of perivascular lymphoplasmacytic and histiocytic inflammation. The distribution of inflammation is only mild (lymphoplasmacytic) elsewhere within the stroma. Curiously, in several foci the inflammation surrounds remnants of salivary duct devoid of glandular tissue. Possibly there is severe salivary atrophy. Diagnosis: Lymphoplasmacytic and histiocytic gingivitis, idiopathic Inflammation adjacent to salivary ducts devoid of glandular tissue suggesting severe glandular atrophy, possible Sjogren's Syndrome Comments: Sjogren's syndrome should present as xerostomia and possibly, keratoconjunctivitis sicca also. Was Xerostomia an issue in this dog? Richard R Dubielzig DVM, Dipl. ACVP (608) 263-9805 e-mail: email@example.com Mitzi Zarfoss, DVM Fellow (608) 262-1938 e-mail: firstname.lastname@example.org Lab-voice (608) 263-4958, fax (608)-262-9150 03/11/2004 20:36 ET REF: 9444490 ZOAS8872 i:ZOASIS TO: 4197930879/-56000984 Page 1 of 1 ANTECH DIAGNOSTICS 1111 Marcus Avenue Lake Success NY 11042 Phone: 800-872-1001 Burnt Store Animal Hospital 11002 Nathan Ct Punta Gorda, FL 33955 Tel: 941-637-6006 Fax: 419-793-0879 Client # 9844490 Chart # Accession No. S6000984 Species Canine Doctor BECKMAN Breed OWner HIGLEY Sex F Pet Name TESSA Pet Age 4Y Received 03/09/2004 Reported 03/11/200408:22 PM Test Requested Results Reference Range Units BIOPSY Biopsy Microscopic Description: The examined oral mass (wedge specimen) is composed of dense collagen with focal fibroplasia, lined by an irregularly hyperplastic epithelium with spongiosis. There is a multifocal superficial and perivascular mixed inflammatory infiltrate composed of plasma cells, lymphocytes. neutrophils and melanophages. Microscopic Findings: Gingiva, inflamed fibrous hyperplasia. Comment: Gingival hyperplasia is a benign growth. The inflammation may represent an atypical immune-mediated response to oral antigens and may accompany periodontal disease. No features of neoplasia are seen. Anna Barthel, DVM,
Reported 03/31/200707:29 PM Test Requested Results Reference Range Units BIOPSY Biopsy Microscopic Description: Section of stratified squamous epithelium subjacent to which is a poorly delineated lesion/mass. The mass is composed of cells arranged haphazardly and supported by a fibrous stroma. The cells are elongate with scant amounts of cytoplasm and a single elongate nucleus. Mitoses are rare. There is moderate diffuse acanthosis of the epithelium. Complete excision is questionable. Microscopic Findings: Oral mucosa, fibrous (fibromatous) epulis Comment: The section is a very thin piece of a lesion. It is largely composed of fibrous connective tissue. It lacks prominent periodontal ligament stroma; however, I suspect fibrous epulis. Fibrous epulis is a benign tumor. They can sometimes regrow after excision and complete excision is questionable in this case, therefore the site should monitored.
2. Posted By Rhea Morgan 12/12/07 19:46 ET Yes, dogs can develop Sjogren's syndrome but it is rare. It was first described in miniature poodles (Clin Immunol Immunopathol 12:471, 1979)but has sporadically been seen in the Maltese and other small breed dogs. Affected dogs have most often been females.Classically these dogs have KCS, xerostomia, and some other autoimmune disorders, such as thrombocytopenia, glomerulonephritis, immuned-mediated hypothyroidism, etc. LE preps and serum ANA assays have been positive in some dogs, but ANA on tissue is often inconclusive.The affected dogs I have managed have had no tear production (STT = 0) and no salivation upon stimulation with topical atropine applied to mouth.Many dogs that are systemically ill (but do not have Sjogren's) can also have a decrease in glandular functions, so other illnesses must also be ruled out to support the diagnosis.Hope this helps,Rhea MorganDiplomate ACVIM, ACVO
Management of Challenging Veterinary Dentistry Cases
Microscopic Findings: Gingiva, inflamed fibrous hyperplasia. Comment: Gingival hyperplasia is a benign growth. The inflammation may represent an atypical immune-mediated response to oral antigens and may accompany periodontal disease. No features of neoplasia are seen. <br />
Lymphoplasmacytic and histiocytic gingivitis, idiopathic <br />Inflammation adjacent to salivary ducts devoid of glandular tissue suggesting severe glandular atrophy, possible Sjogren's Syndrome <br />