Cytogeneticmolecular of cancer<br />Google.images.<br />SNEIDER ALEXANDER TORRES SOTO                                 BIOL...
FOLDING<br />
FOLDING<br />
INTRODUCTION<br />The cytogeneticsis the study of chromosomes in number and in structure, <br />The main technique for hum...
The investigation is to ascertain whether the suppression of chromosome 9p in clear cell renal carcinoma (ccRCC) predicts ...
suppression of chromosome 9<br />Chromosome 9p.<br /><ul><li>When you suppress the chromosome 9p it stops removing large t...
Deletion of chromosome 9p.<br />Deletion of chromosome 9p confers a worse prognosis independent in patients with localized...
Prevention of carcinoma<br />Histological appearance of renal cell carcinoma<br />the identification of patients with 9p d...
Observation .<br />I thinkthatthisstudy has greatclinical application, sinceitallows to determinewhich patients are athigh...
long arm of chromosome 20 is an abnormality of acute myeloid leukemia (AML)and myelodysplastic(MDS) syndrome and is presum...
Tumor suppressor gene<br />Additional copies of chromosome 20 may generate an amplification of the regions of the chromoso...
Activation de an oncogen.<br />By RT-PCR has shown a correlation between amplification and increased expression of gen.<br...
Tumor suppressor gene<br /><ul><li>20q11.21 amplified cases tended to have a high proportion of erythroblasts in the bone,...
Observation<br />frommy point of viewthis investigation allows for a more information about acute myeloidleukemiaresulting...
Citogenetyc<br />Cytogeneticis the branch of geneticthatstudies the diseases of chromosomalinheritanc.<br />
Cytogeneticabnormalities<br />The cytogeneticallowsdetermining the type of chromosomalabnormalityis a diagnostic toolthata...
Cytogenetic and cancer<br />The cytogenetic in the cancer represents and avvantadge for a rapidprevention of manydiseases,...
Role of cytogenetics<br />the cytogenetics plays an important role in these two aforementioned pathologies such as leukemi...
Bibliography<br /> MARTINEZ SÁNCHEZ, Lina  María. Biología molecular. 5. ed. Medellín: UPB. Fac. de Medicina, 2009. 71-72 ...
THANK YOU……………<br />
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Plegable biology 2

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Plegable biology 2

  1. 1. Cytogeneticmolecular of cancer<br />Google.images.<br />SNEIDER ALEXANDER TORRES SOTO BIOLOGY MOLECULAR<br />UPB-MEDELLIN<br />
  2. 2. FOLDING<br />
  3. 3. FOLDING<br />
  4. 4. INTRODUCTION<br />The cytogeneticsis the study of chromosomes in number and in structure, <br />The main technique for humancytogeneticsstudyisrepresented by fluorescence in situ hybridization (FISH), whichisconsidered a technique thatrevolutionized the chromosome analysis in humancytogenetics and emerges as a promising technique in the fieldclinicalgenetics, clinicaloncology and clinicalresearchs.<br />
  5. 5. The investigation is to ascertain whether the suppression of chromosome 9p in clear cell renal carcinoma (ccRCC) predicts worse disease-specific survival (DSS).<br />
  6. 6. suppression of chromosome 9<br />Chromosome 9p.<br /><ul><li>When you suppress the chromosome 9p it stops removing large tumors, creating a greater likelihood of having a high tumor classification.</li></ul>http://dermatology.cdlib.org/<br />
  7. 7. Deletion of chromosome 9p.<br />Deletion of chromosome 9p confers a worse prognosis independent in patients with localized disease ccRCC, and most notably, in patients with localized mass, small kidney<br />
  8. 8. Prevention of carcinoma<br />Histological appearance of renal cell carcinoma<br />the identification of patients with 9p deletions improve risk stratification and help select appropriate patients for surveillance protocols or aggressive treatment.<br />http://escuela.med.puc.cl<br />
  9. 9. Observation .<br />I thinkthatthisstudy has greatclinical application, sinceitallows to determinewhich patients are athighrisk of developingrenal cancer and throughthis to preventdecreasing the morbidity and mortality.<br />
  10. 10. long arm of chromosome 20 is an abnormality of acute myeloid leukemia (AML)and myelodysplastic(MDS) syndrome and is presumed to cause the loss of a tumor suppressor gene in the 20q12.<br />
  11. 11. Tumor suppressor gene<br />Additional copies of chromosome 20 may generate an amplification of the regions of the chromosome where the gene suppressor as in a translocation.<br />
  12. 12. Activation de an oncogen.<br />By RT-PCR has shown a correlation between amplification and increased expression of gen.<br />Localized and high-level amplification of the 250 kb region common is a test for the activation of an oncogene in this region in these cases of MDS and AML.<br />
  13. 13. Tumor suppressor gene<br /><ul><li>20q11.21 amplified cases tended to have a high proportion of erythroblasts in the bone, with two cases diagnosed as erythroleukemia</li></ul>Suppressor gene inactivation<br />Google.images<br />
  14. 14. Observation<br />frommy point of viewthis investigation allows for a more information about acute myeloidleukemiaresulting in a better perspective on this and be able to actat the site of the errorcausing a possible diagnosis.<br />
  15. 15. Citogenetyc<br />Cytogeneticis the branch of geneticthatstudies the diseases of chromosomalinheritanc.<br />
  16. 16. Cytogeneticabnormalities<br />The cytogeneticallowsdetermining the type of chromosomalabnormalityis a diagnostic toolthatallows confirmation of the diagnosis of suchdiseases and also the propergeneticcounseling of patients and theirfamilies ;.<br />
  17. 17. Cytogenetic and cancer<br />The cytogenetic in the cancer represents and avvantadge for a rapidprevention of manydiseases, including cancer recurrentrecurring chromosome in certain malignanttumors<br />
  18. 18. Role of cytogenetics<br />the cytogenetics plays an important role in these two aforementioned pathologies such as leukemia, renal carinomamieloidy and enabling you to identify genetically affected site and provides a pattern in their evolution.<br />
  19. 19. Bibliography<br /> MARTINEZ SÁNCHEZ, Lina María. Biología molecular. 5. ed. Medellín: UPB. Fac. de Medicina, 2009. 71-72 p.<br />
  20. 20. THANK YOU……………<br />

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