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Professor Richard Cotton - Finlay Macrae

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A tribute to Dick Cotton from Finlay Macrae. Part 1 of the inaugural Richard Cotton Memorial lecture.

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Professor Richard Cotton - Finlay Macrae

  1. 1. Dick…in memoriam Finlay Macrae Dept of Colorectal Medicine and Genetics, The Royal Melbourne Hospital, Australia Chair, InSiGHT Colleague, mentor, visionary, inspirational leader and friend Professor Richard Cotton.
  2. 2. Dick interlaced his professional life with his personal life…we all enjoyed his journey, achievements and frustrations… His life was about sharing…
  3. 3. Remarkably indeed, Dick brought the science of agriculture to human health
  4. 4. Professor Richard Cotton…in memoriam Born November 10th 1940, Wangaratta, Victoria • 1963 B Agr Science (Uni of Melbourne) • 1967 PhD Phenylalanine and tyrosine biosynthesis • 1967 Research Fellow John Curtin School of Medical Research, ANU, Canberra • 1968-70 Research Fellow, Clinical Research Unit, Royal Childrens’ Hospital; Dept of Genetics, Uni of Melb • 1970-71 Post doctoral Fellow, Scripps Clinic • 1971-73 Post doc Fellow, MRC Laboratory of Molecular Laboratory, Cambridge UK* • 1973-74 Senior Research Fellow, Dept of Genetics, Uni of Melbourne • 1975- continued to develop monoclonal antibodies as tools in analysis of enzyme function • 1979-80 Sabbatical, Oxford, UK • 1983- Deputy Director, Birth Defects Research Institute, Uni of Melb • 1986-87 Sabbatical, Oxford* • 1991-6 NHMRC (Senior) Principal Research Fellow • 1992 Initiated the journal Human Mutation • 1996 Established Genomic Disorders Research Centre, Uni of Melb • 1997- Executive, Human Genome Organization • 2003 Gen mapping monograph editor, NCBI, Washington, • 2005 Awarded Member of the Order of Australia • 2006- Convenor, initiator, Scientific Director, Human Variome Project
  5. 5. Dick…truly international reach….
  6. 6. Indeed, Dick had extraordinary international reach…. • Extraordinary number of advisory and their roles with international organizations (18) • Faculty and Research team reviews (6) • Journal Abstract reviewer (13) • Editorial Boards (16) • Editorial advisory boards (2) • Journal Editor (1 – Human Mutation) • Invited lectureships and chairs: (145 international; 47 Australian) • Conference organizations: (International 95; Australian 22) • Postgraduate student supervisors and post docs: (66) • Conferences organized (International 95; Australian 22) • Patents (8)
  7. 7. Dick understood that science happens when minds meet …in meetings, not just over the internet…
  8. 8. Prof Richard Cotton…publish!! Publish!! • Referred original journal articles 35 • Refereed journal reviews 9 • Chapters of books 21 • Other publications and influential citations 109 • Editorials 13 • Commissioned reports 5 • Abstracts 73
  9. 9. Dick new that the best way to communicate and spread his vision is to publish and engage with editors..
  10. 10. Dick reached out to China…believing China was both in need and had the resources to respond to his vision…
  11. 11. Dick’s work will impact science for ever… the discovery of the power of monoclonal antibodies • Conceived, planned and executed experiments designed to decide if none, one, or both parental IgGs are produced after two Ig producing cell lines are fused. As the answer was both, these experiments laid the practical and theoretical foundation of monoclonal antibodies by Kohler in Milstein’s lab in Cambridge. This work attracted the Nobel prize and a $15Bpa (2000) industry
  12. 12. Application of monoclonal antibodies… •Detailed examination of a series of antibodies to phenylalanine hydroxylase found one which reacts with tryptophan hydroxylase. This antibody has been used to map serotinergic neurones in the human brain seen for the first time, and to enumerate their decrease in Parkinson’s Syndrome and Alzheimer’s Disease
  13. 13. Mutation Detection meetings spawned an international reputation and community interested in mutation detection “As the best of these methods only detected 70% of all point mutations, I decided to attempt to develop a better method whilst in Oxford where I was fortunate in my quest. I developed a chemical method the chemical cleavage method (CCM) which has the potential to detect all mutations”
  14. 14. Professor Richard Cotton…his greatest legacy… Born November 10th 1940, Wangaratta, Victoria • 1963 B Agr Science (Uni of Melbourne) • 1967 PhD Phenylalanine and tyrosine biosynthesis • 1967 Research Fellow John Curtin School of Medical Research, ANU, Canberra • 1968-70 Research Fellow, Clinical Research Unit, Royal Childrens’ Hospital; Dept of Genetics, Uni of Melb • 1970-71 Post doctoral Fellow, Scripps Clinic • 1971-73 Post doc Fellow, MRC Laboratory of Molecular Laboratory, Cambridge UK* • 1973-74 Senior Research Fellow, Dept of Genetics, Uni of Melbourne • 1975- continued to develop monoclonal antibodies as tools in analysis of enzyme function • 1979-80 Sabbatical, Oxford, UK • 1983- Deputy Director, Birth Defects Research Institute, Uni of Melb • 1986-87 Sabbatical, Oxford* • 1991-6 NHMRC (Senior) Principal Research Fellow • 1992 Initiated the journal Human Mutation • 1996 Established Genomic Disorders Research Centre, Uni of Melb • 1997- Executive, Human Genome Organization • 2003 Gen mapping monograph editor, NCBI, Washington, • 2005 Awarded Member of the Order of Australia • 2006- Convenor, initiator, Scientific Director, Human Variome Project
  15. 15. If for nothing else, Dick’s legacy to InSiGHT is inestimable…but it could be multiplied 26000 times…
  16. 16. Bryony A. Thompson, Amanda B. Spurdle, Marc Greenblatt, John-Paul Plazzer, Kiwamu Akagi, Fahd Al-Mulla, Bharati Bapat, Inge Bernstein, Gabriel Capella, Johan den Dunnen, Desiree du Sart, Mark Farrel, Susan Farrington, Ian Frayling, Thierry Frebourg, David Goldgar, Chris Heinen, Elke Holinski-Feder, Maija Kohonen-Corish, Suet Yi Leung, Annika Lindblom, Kristina Lagerstedt, Alexandra Martins, Pal Moller, Monika Morak, Minna Nystrom, Aurelie Fabre, Paivi Peltomaki, Marta Pineda, Ming Qi, Rajkumar Ramesar, Lene Rasmussen, Brigitte Royer-Pokora, Rodney Scott, Rolf Sijmons, Sean Tavtigian, Carli Tops, Thomas Weber, Juul Wijnen, Michael Woods, Finlay Macrae, Maurizio Genuardi How does the InSiGHT Variant Interpretation Committee operate? Established in Yokohama, 2007International Society for Gastrointestinal Hereditary Tumours
  17. 17. 5-tiered Classification Criteria: www.insight-group.org/criteria/ Standardized & normalized variant classification scheme Thompson, Spurdle et al. Nat Genet 46, 107-15 (2014).
  18. 18. LOVD submission classifications vs InSiGHT VIC variant classifications 0% 10% 20% 30% 40% 50% 60% 70% 80% 90% 100% No known pathogenicity Probably no pathogenicity Unknown Probably pathogenic Pathogenic Class 5b Class 5a Class 4 Class 3 Class 2 Class 1 24% 15% Submitter classification Finalclassification
  19. 19. InSiGHT Mismatch Repair Database Number of monthly database views 0 5000 10000 15000 20000 25000 30000 35000 40000 45000 50000 2008Jul 2008Sep 2008Nov 2009Jan 2009Mar 2009May 2009Jul 2009Sep 2009Nov 2010Jan 2010Mar 2010May 2010Jul 2010Sep 2010Nov 2011Jan 2011Mar 2011May 2011Jul 2011Sep 2011Nov 2012Jan 2012Mar 2012May 2012Jul 2012Sep 2012Nov 2013Jan 2013Mar 2013May 2013Jul 2013Sep 2013Nov 2014Jan 2014Mar 2014May 2014Jul 2014Sep 2014Nov 2015Jan Date
  20. 20. InSiGHT Mismatch Repair Database Number of unique database visitors 0 500 1000 1500 2000 2500 2008Jul 2008Sep 2008Nov 2009Jan 2009Mar 2009May 2009Jul 2009Sep 2009Nov 2010Jan 2010Mar 2010May 2010Jul 2010Sep 2010Nov 2011Jan 2011Mar 2011May 2011Jul 2011Sep 2011Nov 2012Jan 2012Mar 2012May 2012Jul 2012Sep 2012Nov 2013Jan 2013Mar 2013May 2013Jul 2013Sep 2013Nov 2014Jan 2014Mar 2014May 2014Jul 2014Sep 2014Nov 2015Jan DAte
  21. 21. 27/07/12
  22. 22. Dick’s greatest challenge was marketing his message about the need for the Human Variome Project
  23. 23. Nevertheless, Dick was an inspiration for humanity.. Professor Finlay Macrae Chair, InSiGHT Regional Scientific Director, Human Variome Project FOD*
  24. 24. Above all, Dick was a happy family man, who loved his family, and all that life brings… Vale Dick!

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